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Reliable diagnosis of depressive disorder is essential for both optimal treatment and prevention of fatal outcomes. In this study, we aimed to elucidate the effectiveness of two non-linear measures, Higuchi Fractal Dimension (HFD) and…

While EEG features differentiate Major Depressive Disorder (MDD) from healthy controls (HC), their clinical utility as biomarkers depends on a monotonic trajectory across the disease spectrum, from the acute (AC) phase to the maintenance…

Neurons and Cognition · Quantitative Biology 2026-03-05 Feng Yan , Xuteng Wang , Shuyu Yang , Yue Zhao , Xiaobin Wong , Zhiren Wang

Background: Depression has become a major health burden worldwide, and effective detection depression is a great public-health challenge. This Electroencephalography (EEG)-based research is to explore the effective biomarkers for depression…

Signal Processing · Electrical Eng. & Systems 2020-02-26 Shuting Sun , Jianxiu Li , Huayu Chen , Tao Gong , Xiaowei Li , Bin Hu

In universal environment, a patient-friendly inexpensive method is needed to realize the early diagnosis of depression, which is believed to be an effective way to reduce the mortality of depression. The purpose of this study is only to…

Signal Processing · Electrical Eng. & Systems 2020-02-28 Qiuxia Shi , Ang Liu , Rongyan Chen , Jian Shen , Qinglin Zhao , Bin Hu

Alzheimers disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the…

Neurons and Cognition · Quantitative Biology 2022-05-19 Ali H. Al-Nuaimi , Emmanuel Jammeh , Lingfen Sun , Emmanuel Ifeachor

The aim of the study was to examine how the complexity of surface electromyogram (sEMG) signal, estimated by Higuchi fractal dimension (HFD) and Sample Entropy (SampEn), change depending on muscle contraction intensity and external…

Neurons and Cognition · Quantitative Biology 2018-03-29 Milena B. Cukic , Mirjana M. Platisa , Aleksandar Kalauzi , Joji Oommen , Milos R. Ljubisavljevic

Depression is a public health issue which severely affects one's well being and cause negative social and economic effect for society. To rise awareness of these problems, this publication aims to determine if long lasting effects of…

Machine Learning · Computer Science 2022-02-09 Egils Avots , Klavs Jermakovs , Maie Bachmann , Laura Paeske , Cagri Ozcinar , Gholamreza Anbarjafari

The present literature about possible mechanisms behind the effectivity of noninvasive electromagnetic stimulation in major depressive disorder (MDD) is not very rich. Despite extensive research in applications for clinical practice, the…

Neurons and Cognition · Quantitative Biology 2019-12-19 Milena Cukic

There are reasons to suggest that a number of mental disorders may be related to alteration in the neural complexity (NC). Thus, quantitative analysis of NC could be helpful in classifying mental and understanding conditions. Here, focusing…

Neurons and Cognition · Quantitative Biology 2024-09-02 Dimitri Marques Abramov , Henrique Santos Lima , Vladimir Lazarev , Paulo Ricardo Galhanone , Constantino Tsallis

In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major…

Neurons and Cognition · Quantitative Biology 2019-03-28 Milena Cukic Radenkovic

Depression is a major cause of global mental illness and significantly influences suicide rates. Timely and accurate diagnosis is essential for effective intervention. Electroencephalography (EEG) provides a non-invasive and accessible…

Signal Processing · Electrical Eng. & Systems 2025-11-11 Soujanya Hazra , Sanjay Ghosh

Mental disorders present challenges in diagnosis and treatment due to their complex and heterogeneous nature. Electroencephalogram (EEG) has shown promise as a potential biomarker for these disorders. However, existing methods for analyzing…

Methodology · Statistics 2024-01-30 Xingche Guo , Bin Yang , Ji Meng Loh , Qinxia Wang , Yuanjia Wang

Depression is a widespread mental health disorder, yet its automatic detection remains challenging. Prior work has explored unimodal and multimodal approaches, with multimodal systems showing promise by leveraging complementary signals.…

Artificial Intelligence · Computer Science 2026-03-24 Annisaa Fitri Nurfidausi , Eleonora Mancini , Paolo Torroni

We calculate a measure of statistical complexity from the global dynamics of electroencephalographic (EEG) signals from healthy subjects and epileptic patients, and are able to stablish a criterion to characterize the collective behavior in…

Adaptation and Self-Organizing Systems · Physics 2015-05-13 M. Escalona-Moran , M. G. Cosenza , R. Lopez-Ruiz , P. Garcia

Depression disorder is a serious health condition that has affected the lives of millions of people around the world. Diagnosis of depression is a challenging practice that relies heavily on subjective studies and, in most cases, suffers…

Signal Processing · Electrical Eng. & Systems 2025-03-26 Amir Nassibi , Christos Papavassiliou , Ildar Rakhmatulin , Danilo Mandic , S. Farokh Atashzar

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing…

We investigate the nature of the modifications in the temporal dynamics manifested in the high-frequency EEG spectra of the normal human brain in comparison to the diseased brain undergoing epilepsy. For this purpose, the Fourier…

Chaotic Dynamics · Physics 2025-08-19 Jyotiraj Nath , Shreya Banerjee , Bhaswati Singha Deo , Mayukha Pal , Prasanta K. Panigrahi

When using Head-Mounted Displays (HMDs), users may not always notice or report visual discomfort by blurred vision through unadjusted lenses, motion sickness, and increased eye strain. Current measures for visual discomfort rely on users'…

Human-Computer Interaction · Computer Science 2024-07-29 Francesco Chiossi , Yannick Weiss , Thomas Steinbrecher , Christian Mai , Thomas Kosch

Depression and suicidality affect cognitive and emotional processes, yet objective, task-evoked neural readouts of mental health remain limited. We investigated the spatiotemporal dynamics of affective semantic processing using multivariate…

This study investigates the detection and classification of depressive and non-depressive states using deep learning approaches. Depression is a prevalent mental health disorder that substantially affects quality of life, and early…

Quantitative Methods · Quantitative Biology 2026-01-19 Mohammad Reza Yousefi , Hajar Ismail Al-Tamimi , Amin Dehghani
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