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Quantum computing offers significant potential for solving NP-hard combinatorial (optimization) problems that are beyond the reach of classical computers. One way to tap into this potential is by reformulating combinatorial problems as a…

We present a quantum feature-selection framework based on a higher-order unconstrained binary optimization (HUBO) formulation that explicitly incorporates multivariate dependencies beyond standard quadratic encodings. In contrast to…

Quantum algorithms have shown promise in solving Quadratic Unconstrained Binary Optimization (QUBO) problems, benefiting from their connection to the transverse field Ising model. Various Ising solvers, both classical and quantum, have…

Optimization and Control · Mathematics 2025-09-16 Zedong Peng , Daniel de Roux , David E. Bernal Neira

Quadratic Unconstrained Binary Optimization (QUBO) is a generic technique to model various NP-hard combinatorial optimization problems in the form of binary variables. The Hamiltonian function is often used to formulate QUBO problems where…

Artificial Intelligence · Computer Science 2023-09-29 Redwan Ahmed Rizvee , Md. Mosaddek Khan

Quadratic Unconstrained Binary Optimization (QUBO or UBQP) is concerned with maximizing/minimizing the quadratic form $H(J, \eta) = W \sum_{i,j} J_{i,j} \eta_{i} \eta_{j}$ with $J$ a matrix of coefficients, $\eta \in \{0, 1\}^N$ and $W$ a…

Probability · Mathematics 2024-07-02 Marco Isopi , Benedetto Scoppola , Alessio Troiani

The Operational Fixed Interval Scheduling Problem aims to find an assignment of jobs to machines that maximizes the total weight of the completed jobs. We introduce a new variant of the problem where we consider the additional goal of…

Emerging Technologies · Computer Science 2023-10-24 Ludmila Botelho , Özlem Salehi

This tutorial offers a quick, hands-on introduction to solving Quadratic Unconstrained Binary Optimization (QUBO) models on currently available quantum computers and their simulators. We cover both IBM and D-Wave machines: IBM utilizes a…

Quantum Physics · Physics 2025-06-18 Arul Mazumder , Sridhar Tayur

The peptide-protein docking problem is an important problem in structural biology that facilitates rational and efficient drug design. In this work, we explore modeling and solving this problem with the quantum-amenable quadratic…

Constrained combinatorial optimization problems are frequently reformulated as quadratic unconstrained binary optimization (QUBO) models in order to leverage emerging quantum optimization algorithms such as the Variational Quantum…

Quantum Physics · Physics 2026-04-23 Xin Wei Lee , Hoong Chuin Lau

Quadratic Unconstrained Binary Optimization (QUBO) is a generic technique to model various NP-hard Combinatorial Optimization problems (CO) in the form of binary variables. Ising Hamiltonian is used to model the energy function of a system.…

Machine Learning · Computer Science 2023-12-13 Redwan Ahmed Rizvee , Raheeb Hassan , Md. Mosaddek Khan

With the applications of quantum computing becoming more and more widespread, finding ways that allow end users without experience in the field to apply quantum computers to solve their individual problems is becoming a crucial task.…

Quantum Physics · Physics 2024-04-18 Damian Rovara , Nils Quetschlich , Robert Wille

We propose a new kernel that quantifies success for the task of computing a core-periphery partition for an undirected network. Finding the associated optimal partitioning may be expressed in the form of a quadratic unconstrained binary…

Social and Information Networks · Computer Science 2022-01-06 Catherine F. Higham , Desmond J. Higham , Francesco Tudisco

In this paper we present a novel strategy to solve optimization problems within a hybrid quantum-classical scheme based on quantum annealing, with a particular focus on QUBO problems. The proposed algorithm is based on an iterative…

Quantum Physics · Physics 2020-04-07 Enrico Blanzieri , Davide Pastorello

Quantum annealing is a method developed to solve combinatorial optimization problems by utilizing quantum bits. Solving such problems corresponds to minimizing a cost function defined over binary variables. However, in many practical cases,…

Quantum Physics · Physics 2025-06-26 Seiya Endo , Shohei Kawakatsu , Hiromichi Matsuyama , Kohei Suzuki , Yuichiro Matsuzaki

With the advances in customized hardware for quantum annealing and digital/CMOS Annealing, Quadratic Unconstrained Binary Optimization (QUBO) models have received growing attention in the optimization literature. Motivated by an existing…

Quantum Physics · Physics 2024-04-05 Oksana Pichugina , Yingcong Tan , Christopher Beck

Quadratic unconstrained binary optimization (QUBO) problems are well-studied, not least because they can be approached using contemporary quantum annealing or classical hardware acceleration. However, due to limited precision and hardware…

Quantum Physics · Physics 2023-07-06 Sascha Mücke , Thore Gerlach , Nico Piatkowski

Quantum annealing is a heuristic quantum algorithm which exploits quantum resources to minimize an objective function embedded as the energy levels of a programmable physical system. To take advantage of a potential quantum advantage, one…

Machine Learning · Computer Science 2014-06-18 Ryan Babbush , Vasil Denchev , Nan Ding , Sergei Isakov , Hartmut Neven

Quantum computing is developing fast. Real world applications are within reach in the coming years. One of the most promising areas is combinatorial optimisation, where the Quadratic Unconstrained Binary Optimisation (QUBO) problem…

Quantum Physics · Physics 2020-07-06 Frank Phillipson , Irina Chiscop

This paper presents key enhancements to our previous work~\cite{naghmouchi2024mixed} on a hybrid Benders decomposition (HBD) framework for solving mixed integer linear programs (MILPs). In our approach, the master problem is reformulated as…

Quantum Physics · Physics 2026-01-23 Anna Joliot , M. Yassine Naghmouchi , Wesley Coelho

In machine learning, fewer features reduce model complexity. Carefully assessing the influence of each input feature on the model quality is therefore a crucial preprocessing step. We propose a novel feature selection algorithm based on a…

Quantum Physics · Physics 2023-02-22 Sascha Mücke , Raoul Heese , Sabine Müller , Moritz Wolter , Nico Piatkowski