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The human brain cortical layer has a convoluted morphology that is unique to each individual. Characterization of the cortical morphology is necessary in longitudinal studies of structural brain change, as well as in discriminating…

Neurons and Cognition · Quantitative Biology 2019-02-21 Sevil Maghsadhagh , Anders Eklund , Hamid Behjat

Quantification of brain morphology has become an important cornerstone in understanding brain structure. Measures of cortical morphology such as thickness and surface area are frequently used to compare groups of subjects or characterise…

Neurons and Cognition · Quantitative Biology 2020-03-25 Yujiang Wang , Tobias Ludwig , Bethany Little , Joe H Necus , Gavin Winston , Sjoerd B Vos , Jane de Tisi , John S Duncan , Peter N Taylor , Bruno Mota

Brain morphometry study plays a fundamental role in neuroimaging research. In this work, we propose a novel method for brain surface morphometry analysis based on surface foliation theory. Given brain cortical surfaces with automatically…

Computational Geometry · Computer Science 2018-09-11 Chengfeng Wen , Na Lei , Ming Ma , Xin Qi , Wen Zhang , Yalin Wang , David Xianfeng Gu

Identifying cerebral cortex layers is crucial for comparative studies of the cytoarchitecture aiming at providing insights into the relations between brain structure and function across species. The absence of extensive annotated datasets…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Valentina Vadori , Antonella Peruffo , Jean-Marie Graïc , Giulia Vadori , Livio Finos , Enrico Grisan

The universal scaling law of cortical morphology describes cortical folding as the covariance of average grey matter thickness, pial surface area, and exposed surface area. It applies for mammalian species, humans, and across lobes, however…

Neurons and Cognition · Quantitative Biology 2021-03-29 Karoline Leiberg , Christoforos Papasavvas , Yujiang Wang

The human cortical layer exhibits a convoluted morphology that is unique to each individual. Conventional volumetric fMRI processing schemes take for granted the rich information provided by the underlying anatomy. We present a method to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-12 Hamid Behjat , Martin Larsson

Background: We have previously demonstrated that cortical folding across mammalian species follows a universal scaling law that can be derived from a simple theoretical model. The same scaling law has also been shown to hold across brains…

Neurons and Cognition · Quantitative Biology 2020-06-01 Yujiang Wang , Joe Necus , Luis Peraza Rodriguez , Peter Neal Taylor , Bruno Mota

Nervous systems are characterized by neurons displaying a diversity of morphological shapes. Traditionally, different shapes have been qualitatively described based on visual inspection and quantitatively described based on morphometric…

Neurons and Cognition · Quantitative Biology 2016-03-29 Lida Kanari , Paweł Dłotko , Martina Scolamiero , Ran Levi , Julian Shillcock , Kathryn Hess , Henry Markram

The shape and connectivity of a neuron determine its function. Modern imaging methods have proven successful at extracting such information. However, in order to analyze this type of data, neuronal morphology needs to be encoded in a…

Neurons and Cognition · Quantitative Biology 2019-03-07 Tamal Batabyal , Barry Condron , Scott T. Acton

In this paper, we present a novel method for analysis and segmentation of laminar structure of the cortex based on tissue characteristics whose change across the gray matter underlies distinctive between cortical layers. We develop and…

Computer Vision and Pattern Recognition · Computer Science 2019-12-16 Andrija Štajduhar , Tomislav Lipić , Goran Sedmak , Sven Lončarić , Miloš Judaš

Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt

Neuronal cell bodies mostly reside in the cerebral cortex. The study of this thin and highly convoluted surface is essential for understanding how the brain works. The analysis of surface data is, however, challenging due to the high…

Computer Vision and Pattern Recognition · Computer Science 2018-03-29 Karthik Gopinath , Christian Desrosiers , Herve Lombaert

Classification and quantitative characterization of neuronal morphologies from histological neuronal reconstruction is challenging since it is still unclear how to delineate a neuronal cell class and which are the best features to define…

Neurons and Cognition · Quantitative Biology 2025-03-05 Xavier Vasques , Laurent Vanel , Guillaume Villette , Laura Cif

The emergence of explainability methods has enabled a better comprehension of how deep neural networks operate through concepts that are easily understood and implemented by the end user. While most explainability methods have been designed…

Neurons and Cognition · Quantitative Biology 2022-03-17 Fernanda L. Ribeiro , Steffen Bollmann , Ross Cunnington , Alexander M. Puckett

Brain can be represented as a network, where regions are the nodes and relations between the regions are edges. Within a network, co-existence of cooperative and competitive relationships between different nodes is called coopetition.…

Neurons and Cognition · Quantitative Biology 2018-02-13 Subhadip Paul , Satyam Mukherjee , Sagnik Bhattacharyya

Motivation: Characterising the changes in cortical morphology across the lifespan is fundamental for a range of research and clinical applications. Most studies to date have found a monotonic decrease in commonly used morphometrics, such as…

The brain can be regarded as a network: a connected system where nodes, or units, represent different specialized regions and links, or connections, represent communication pathways. From a functional perspective communication is coded by…

Neurons and Cognition · Quantitative Biology 2014-09-10 Fabrizio De Vico Fallani , Jonas Richiardi , Mario Chavez , Sophie Achard

Population-wise matching of the cortical fold is necessary to identify biomarkers of neurological or psychiatric disorders. The difficulty comes from the massive interindividual variations in the morphology and spatial organization of the…

Machine Learning · Statistics 2023-02-01 Rohit Yadav , François-Xavier Dupé , S. Takerkart , Guillaume Auzias

Neuronal morphology encodes critical information about circuit function, development, and disease, yet current methods analyze topology or graph structure in isolation. We introduce GraPHFormer, a multimodal architecture that unifies these…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Uzair Shah , Marco Agus , Mahmoud Gamal , Mahmood Alzubaidi , Corrado Cali , Pierre J. Magistretti , Abdesselam Bouzerdoum , Mowafa Househ

Surface analysis of the cortex is ubiquitous in human neuroimaging with MRI, e.g., for cortical registration, parcellation, or thickness estimation. The convoluted cortical geometry requires isotropic scans (e.g., 1mm MPRAGEs) and good…

Image and Video Processing · Electrical Eng. & Systems 2023-05-04 Karthik Gopinath , Douglas N. Greve , Sudeshna Das , Steve Arnold , Colin Magdamo , Juan Eugenio Iglesias
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