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While data-driven confounder selection requires careful consideration, it is frequently employed in observational studies. Widely recognized criteria for confounder selection include the minimal-set approach, which involves selecting…

Methodology · Statistics 2025-08-21 Kazuharu Harada , Masataka Taguri

Recent generative adversarial networks (GANs) are able to generate impressive photo-realistic images. However, controllable generation with GANs remains a challenging research problem. Achieving controllable generation requires semantically…

Machine Learning · Computer Science 2021-05-04 Grigorios G Chrysos , Jean Kossaifi , Zhiding Yu , Anima Anandkumar

This paper states that Model-Free Control (MFC), which must not be confused with Model-Free Reinforcement Learning, is a new tool for Machine Learning (ML). MFC is easy to implement and should be substituted in control engineering to ML via…

Systems and Control · Electrical Eng. & Systems 2020-12-11 Michel Fliess , Cédric Join

Human interpretability of deep neural networks' decisions is crucial, especially in domains where these directly affect human lives. Counterfactual explanations of already trained neural networks can be generated by perturbing input…

Computer Vision and Pattern Recognition · Computer Science 2021-02-02 Oana-Iuliana Popescu , Maha Shadaydeh , Joachim Denzler

In this work, we introduce a method to fine-tune a Transformer-based generative model for molecular de novo design. Leveraging the superior sequence learning capacity of Transformers over Recurrent Neural Networks (RNNs), our model can…

Machine Learning · Computer Science 2024-03-11 Pengcheng Xu , Tao Feng , Tianfan Fu , Siddhartha Laghuvarapu , Jimeng Sun

Multiple testing with false discovery rate (FDR) control has been widely conducted in the ``discrete paradigm" where p-values have discrete and heterogeneous null distributions. However, in this scenario existing FDR procedures often lose…

Methodology · Statistics 2019-07-23 Xiongzhi Chen , R. W. Doerge , Sanat K. Sarkar

The model-X conditional randomization test is a generic framework for conditional independence testing, unlocking new possibilities to discover features that are conditionally associated with a response of interest while controlling type-I…

Machine Learning · Computer Science 2023-02-21 Shalev Shaer , Yaniv Romano

We consider the problem of variable selection in high-dimensional statistical models where the goal is to report a set of variables, out of many predictors $X_1, \dotsc, X_p$, that are relevant to a response of interest. For linear…

Methodology · Statistics 2019-03-20 Adel Javanmard , Hamid Javadi

The concept of $k$-FWER has received much attention lately as an appropriate error rate for multiple testing when one seeks to control at least $k$ false rejections, for some fixed $k\ge 1$. A less conservative notion, the $k$-FDR, has been…

Statistics Theory · Mathematics 2009-06-18 Sanat K. Sarkar , Wenge Guo

We propose and demonstrate a nonlinear control method that can be applied to unknown, complex systems where the controller is based on a type of artificial neural network known as a reservoir computer. In contrast to many modern…

Systems and Control · Electrical Eng. & Systems 2020-10-07 Daniel Canaday , Andrew Pomerance , Daniel J Gauthier

The knockoff-based multiple testing setup of Barber & Candes (2015) for variable selection in multiple regression where sample size is as large as the number of explanatory variables is considered. The method of Benjamini & Hochberg (1995)…

Methodology · Statistics 2021-08-20 Sanat K. Sarkar , Cheng Yong Tang

Effectively controlling the false discovery rate (FDR) in high-dimensional variable selection is a fundamental statistical problem that has garnered significant research interest. In this paper, we propose a novel, user-friendly, and…

Methodology · Statistics 2026-04-28 Yujia Wu , Panxu Yuan , Binyan Jiang

We propose sequential multiple testing procedures which control the false discover rate (FDR) or the positive false discovery rate (pFDR) under arbitrary dependence between the data streams. This is accomplished by "optimizing" an upper…

Methodology · Statistics 2024-11-27 Michael Hankin , Jay Bartroff

We study reinforcement learning for the optimal control of Branching Markov Decision Processes (BMDPs), a natural extension of (multitype) Branching Markov Chains (BMCs). The state of a (discrete-time) BMCs is a collection of entities of…

Machine Learning · Computer Science 2021-06-15 Ernst Moritz Hahn , Mateo Perez , Sven Schewe , Fabio Somenzi , Ashutosh Trivedi , Dominik Wojtczak

The ability of learning disentangled representations represents a major step for interpretable NLP systems as it allows latent linguistic features to be controlled. Most approaches to disentanglement rely on continuous variables, both for…

Computation and Language · Computer Science 2021-09-16 Giangiacomo Mercatali , André Freitas

There is a challenge in selecting high-dimensional mediators when the mediators have complex correlation structures and interactions. In this work, we frame the high-dimensional mediator selection problem into a series of hypothesis tests…

Methodology · Statistics 2025-09-16 Runqiu Wang , Ran Dai , Jieqiong Wang , Kah Meng Soh , Ziyang Xu , Mohamed Azzam , Hongying Dai , Cheng Zheng

Voxel-based multiple testing is widely used in neuroimaging data analysis. Traditional false discovery rate (FDR) control methods often ignore the spatial dependence among the voxel-based tests and thus suffer from substantial loss of…

Machine Learning · Statistics 2024-05-06 Taehyo Kim , Hai Shu , Qiran Jia , Mony J. de Leon

The traditional approaches to false discovery rate (FDR) control in multiple hypothesis testing are usually based on the null distribution of a test statistic. However, all types of null distributions, including the theoretical,…

Methodology · Statistics 2021-04-13 Kun He , Mengjie Li , Yan Fu , Fuzhou Gong , Xiaoming Sun

The perturbation of a transcription factor should affect the expression levels of its direct targets. However, not all genes showing changes in expression are direct targets. To increase the chance of detecting direct targets, we propose a…

Methodology · Statistics 2018-07-19 Leying Guan , Xi Chen , Wing Hung Wong

Discovering non-linear dynamical models from data is at the core of science. Recent progress hinges upon sparse regression of observables using extensive libraries of candidate functions. However, it remains challenging to model hidden…