Related papers: Optimizing Bone Scaffold Porosity Distributions
Distributed storage systems provide large-scale reliable data storage services by spreading redundancy across a large group of storage nodes. In such a large system, node failures take place on a regular basis. When a storage node breaks…
Long-term bone healing/adaptation after a dental implant treatment starts with diffusion of mesenchymal stem cells to the fracture callus and their subsequent differentiation. The healing phase is followed by the bone-remodeling phase. In…
Topology optimization is able to maximally leverage the high DOFs and mechanical potentiality of porous foams but faces three fundamental challenges: conforming to free-form outer shapes, maintaining geometric connectivity between adjacent…
A multi-scale methodology is developed in conjunction with a probabilistic fatigue lifetime model for structures with pores whose exact distribution, i.e. geometries and locations, is unknown. The method takes into account uncertainty in…
Variations of physical and chemical characteristics of biomass lead to an uneven flow of biomass in a biorefinery, which reduces equipment utilization and increases operational costs. Uncertainty of biomass supply and high processing costs…
The collective strength of a system of fibers, each having a failure threshold drawn randomly from a distribution, indicates the maximum load carrying capacity of different disordered systems ranging from disordered solids, power-grid…
We propose an adaptive polygonal finite element formulation for collapse plastic analysis of solids. The article contributes into four crucial points: 1) Wachspress shape functions at vertex and bubble nodes handled at a primal-mesh level;…
We develop and analyze algorithms for distributionally robust optimization (DRO) of convex losses. In particular, we consider group-structured and bounded $f$-divergence uncertainty sets. Our approach relies on an accelerated method that…
We derive a model for the optimization of the bending and torsional rigidities of non-homogeneous elastic rods. This is achieved by studying a sharp interface shape optimization problem with perimeter penalization, that treats both…
To overcome the brittleness limitation of ceramics, various toughening mechanisms have been proposed. Some of the most remarkable, especially for oxides, include the tetragonal-to-monoclinic phase transformation leading to crack shielding…
We study the elasticity of fibrous materials composed of generalized stiff polymers. It is shown that in contrast to cellular foam-like structures affine strain fields are generically unstable. Instead, a subtle interplay between the…
Via large-scale molecular dynamics simulations, we observe the melting of a topological glass of stiff ring polymers by incorporating flexible ring polymers, along an isobaric path. As more flexible ring polymers are introduced, cluster…
The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaffolds were fabricated by a foam replica…
We consider the problem of selecting an optimal mask for an image manifold, i.e., choosing a subset of the pixels of the image that preserves the manifold's geometric structure present in the original data. Such masking implements a form of…
The structural design process for buildings is time-consuming and laborious. To automate this process, structural engineers combine optimization methods with simulation tools to find an optimal design with minimal building mass subject to…
Functionally Graded Materials (FGMs) made of soft constituents have emerged as promising material-structure systems in potential applications across many engineering disciplines, such as soft robots, actuators, energy harvesting, and tissue…
Constraint-based optimization of microbial strains and model-based bioprocess design have been used extensively to enhance yields in biotechnological processes. However, strain and process optimization are usually carried out in sequential…
Planning of biorefinery operations is complicated by the stochastic nature of physical and chemical characteristics of biomass feedstock, such as, moisture level and carbohydrate content. Biomass characteristics affect the performance of…
The project aims to explore a novel way to design and produce cellular materials with good energy absorption and recoverability properties. Spinodoid structures offer an alternative to engineering structures such as honeycombs and foam with…
We report on a novel dual-structure scaffold fabricated using two-photon polymerisation (2PP), integrating electrically conductive and non-conductive regions within a single architecture, targeting neural tissue regeneration. Poly(ethylene…