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The classical likelihood ratio test (LRT) based on the asymptotic chi-squared distribution of the log likelihood is one of the fundamental tools of statistical inference. A recent universal LRT approach based on sample splitting provides…

Methodology · Statistics 2022-11-22 Robin Dunn , Aaditya Ramdas , Sivaraman Balakrishnan , Larry Wasserman

The likelihood ratio test (LRT) is widely used for comparing the relative fit of nested latent variable models. Following Wilks' theorem, the LRT is conducted by comparing the LRT statistic with its asymptotic distribution under the…

Statistics Theory · Mathematics 2025-01-08 Yunxiao Chen , Irini Moustaki , Haoran Zhang

We consider the conditional randomization test as a way to account for covariate imbalance in randomized experiments. The test accounts for covariate imbalance by comparing the observed test statistic to the null distribution of the test…

Quantifying the usefulness of individual features in random forests learning can greatly enhance its interpretability. Existing studies have shown that some popularly used feature importance measures for random forests suffer from the bias…

Machine Learning · Statistics 2023-11-14 Chien-Ming Chi , Yingying Fan , Jinchi Lv

We applaud Fiksel (2024) for their valuable contributions to randomization-based inference, particularly their work on inverting the Fisher randomization test (FRT) to construct confidence intervals using the covariate-adjusted test…

Methodology · Statistics 2025-02-27 Ke Zhu , Hanzhong Liu

Global hypothesis tests are a useful tool in the context of, e.g, clinical trials, genetic studies or meta analyses, when researchers are not interested in testing individual hypotheses, but in testing whether none of the hypotheses is…

Methodology · Statistics 2017-09-05 Andreas Futschik , Thomas Taus , Sonja Zehetmayer

Interference exists when a unit's outcome depends on another unit's treatment assignment. For example, intensive policing on one street could have a spillover effect on neighboring streets. Classical randomization tests typically break down…

Methodology · Statistics 2021-05-26 David Puelz , Guillaume Basse , Avi Feller , Panos Toulis

We introduce a rigorous and sensitive significance test for hyperuniformity that yields reliable results even from a single sample. Our approach is based on a detailed analysis of the empirical Fourier transform of a stationary point…

Statistics Theory · Mathematics 2026-03-23 Michael A. Klatt , Günter Last , Norbert Henze

We address the issue of performing testing inference in generalized linear models when the sample size is small. This class of models provides a straightforward way of modeling normal and non-normal data and has been widely used in several…

Methodology · Statistics 2013-08-16 Tiago M. Vargas , Silvia L. P. Ferrari , Artur J. Lemonte

The Influence Function (IF) is a widely used technique for assessing the impact of individual training samples on model predictions. However, existing IF methods often fail to provide reliable influence estimates in deep neural networks,…

Machine Learning · Computer Science 2025-12-02 Xichen Ye , Yifan Wu , Weizhong Zhang , Cheng Jin , Yifan Chen

Randomized controlled trials (RCTs) provide strong internal validity compared with observational studies. However, selection bias threatens the external validity of randomized trials. Thus, RCT results may not apply to either broad public…

Methodology · Statistics 2017-04-26 Ziyue Chen , Eloise Kaizar

In many applications, hypothesis testing is based on an asymptotic distribution of statistics. The aim of this paper is to clarify and extend multiple correction procedures when the statistics are asymptotically Gaussian. We propose a…

Statistics Theory · Mathematics 2020-07-03 Sophie Achard , Pierre Borgnat , Irène Gannaz

Randomized Controlled Trials (RCT)s are relied upon to assess new treatments, but suffer from limited power to guide personalized treatment decisions. On the other hand, observational (i.e., non-experimental) studies have large and diverse…

Methodology · Statistics 2023-03-07 Zeshan Hussain , Ming-Chieh Shih , Michael Oberst , Ilker Demirel , David Sontag

Hypothesis testing in contingency tables is usually based on asymptotic results, thereby restricting its proper use to large samples. To study these tests in small samples, we consider the likelihood ratio test and define an accurate index,…

Methodology · Statistics 2018-10-04 Natalia L. Oliveira , Carlos A. de B. Pereira , Marcio A. Diniz , Adriano Polpo

Random testing (RT) is a well-studied testing method that has been widely applied to the testing of many applications, including embedded software systems, SQL database systems, and Android applications. Adaptive random testing (ART) aims…

Software Engineering · Computer Science 2020-07-15 Rubing Huang , Weifeng Sun , Yinyin Xu , Haibo Chen , Dave Towey , Xin Xia

A test based on tapering is proposed for use in testing a global linear hypothesis under a functional linear model. The test statistic is constructed as a weighted sum of squared linear combinations of Fourier coefficients, a tapered…

Statistics Theory · Mathematics 2008-10-09 Dan J. Spitzner

Negative control is a common technique in scientific investigations and broadly refers to the situation where a null effect (''negative result'') is expected. Motivated by a real proteomic dataset, we will present three promising and…

Methodology · Statistics 2023-03-21 Zijun Gao , Qingyuan Zhao

Multiple testing problems are a staple of modern statistical analysis. The fundamental objective of multiple testing procedures is to reject as many false null hypotheses as possible (that is, maximize some notion of power), subject to…

Methodology · Statistics 2020-11-30 Saharon Rosset , Ruth Heller , Amichai Painsky , Ehud Aharoni

Mendelian randomization is the use of genetic variants as instrumental variables to assess whether a risk factor is a cause of a disease outcome. Increasingly, Mendelian randomization investigations are conducted on the basis of summarized…

Applications · Statistics 2015-12-15 Stephen Burgess , Jack Bowden

In this article, we study the hypothesis testing of the blip / net effects of treatments in a treatment sequence. We illustrate that the likelihood ratio test and the score test may suffer from the curse of dimensionality, the null paradox…

Methodology · Statistics 2020-02-04 Xiaoqin Wang , Li Yin