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Active processes drive and guide biological dynamics across scales -- from subcellular cytoskeletal remodelling, through tissue development in embryogenesis, to population-level bacterial colonies expansion. In each of these, biological…

Kinesin and related motor proteins utilize ATP fuel to propel themselves along the external surface of microtubules in a processive and directional fashion. We show that the observed step-like motion is possible through time varying charge…

Biomolecules · Quantitative Biology 2007-05-23 A. Ciudad , J. M. Sancho , G. P. Tsironis

While studies of active nematics in two dimensions have shed light on various aspects of the flow regimes and topology of active matter, three-dimensional properties of topological defects and chaotic flows remain unexplored. By confining a…

Soft Condensed Matter · Physics 2018-07-18 Tyler N. Shendruk , Kristian Thijssen , Julia M. Yeomans , Amin Doostmohammadi

We consider the hydrodynamic theory of an active fluid of self-propelled particles with nematic aligning interactions. This class of materials has polar symmetry at the microscopic level, but forms macrostates of nematic symmetry. We…

Soft Condensed Matter · Physics 2012-04-17 Aparna Baskaran , M. Cristina Marchetti

Engineering synthetic materials that mimic the remarkable complexity of living organisms is a fundamental challenge in science and technology. We study the spatiotemporal patterns that emerge when an active nematicfilm of microtubules and…

We use active nematohydrodynamics to study the flow of an active fluid in a 3D microchannel, finding a transition between active turbulence and regimes where there is a net flow along the channel. We show that the net flow is only possible…

Soft Condensed Matter · Physics 2020-10-07 Santhan Chandragiri , Amin Doostmohammadi , Julia M. Yeomans , Sumesh P. Thampi

Two-dimensional active nematics are often modeled using phenomenological continuum theories that describe the dynamics of the nematic director and fluid velocity through partial differential equations (PDEs). While these models provide a…

With exquisite precision and reproducibility, cells orchestrate the cooperative action of thousands of nanometer-sized molecular motors to carry out mechanical tasks at much larger length scales, such as cell motility, division and…

Soft Condensed Matter · Physics 2013-01-08 Tim Sanchez , Daniel T. N. Chen , Stephen J. DeCamp , Michael Heymann , Zvonimir Dogic

The emergence of long-range spatiotemporal order from intrinsic chaos is a central challenge in far-from-equilibrium physics. In active fluids, such as cytoskeletal networks driving cellular motion, self-generated flows typically produce…

Active nematics are materials composed of mobile, elongated particles that can transform energy from the environment into a mechanical motion. Current experimental realizations of the active nematics are of biological origin and include…

Soft Condensed Matter · Physics 2024-06-05 Andrey Sokolov , Jaideep Katuri , Juan J. de Pablo , Alexey Snezhko

Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essential functions. Controlling those dynamics and transport in…

Using the model for the processive movement of a dimeric kinesin we proposed before, we study the dynamics of a number of mutant homodimeric and heterodimeric kinesins that were constructed by Kaseda et al. (Kaseda, K., Higuchi, H. and…

Biomolecules · Quantitative Biology 2007-05-23 Ping Xie , Shuo-Xing Dou , Peng-Ye Wang

We examine the scaling with activity of the emergent length scales that control the nonequilibrium dynamics of an active nematic liquid crystal, using two popular hydrodynamic models that have been employed in previous studies. In both…

Soft Condensed Matter · Physics 2016-09-05 E. J. Hemingway , P. Mishra , M. C. Marchetti , S. M. Fielding

In vitro reconstituted active systems, such as the ATP-driven microtubule bundle suspension developed by the Dogic group, provide a fertile testing ground for elucidating the phenomenology of active liquid crystalline states. Controlling…

Soft Condensed Matter · Physics 2017-01-04 Pau Guillamat , Jordi Ignés-Mullol , Suraj Shankar , M. Cristina Marchetti , Francesc Sagués

Topological defects play a prominent role in the physics of two-dimensional materials. When driven out of equilibrium in active nematics, disclinations can acquire spontaneous self-propulsion and drive self-sustained flows upon…

Soft Condensed Matter · Physics 2019-12-06 Suraj Shankar , M. Cristina Marchetti

We present a thermodynamically consistent energetic variational model for active nematics driven by ATP hydrolysis, with a focus on the coupling between chemical reactions and mechanical dynamics. Extending the classical Toner-Tu framework,…

Soft Condensed Matter · Physics 2025-07-01 Yiwei Wang

In microtubule-based active nematics, motor-driven extensile motion of microtubule bundles powers chaotic large-scale dynamics. We quantify the interfilament sliding motion both in isolated bundles and in a dense active nematic. The…

Topological defects are at the root of the large-scale organization of liquid crystals. In two-dimensional active nematics, two classes of topological defects of charges $\pm 1/2$ are known to play a major role due to active stresses.…

Soft Condensed Matter · Physics 2022-04-08 Louis Brézin , Thomas Risler , Jean-François Joanny

We show that confining extensile nematics in 3D channels leads to the emergence of two self-organized flow states with nonzero helicity. The first is a pair of braided anti-parallel streams - this double helix occurs when the activity is…

Soft Condensed Matter · Physics 2024-04-12 Ryan Keogh , Santhan Chandragiri , Benjamin Loewe , Tapio Ala-Nissila , Sumesh Thampi , Tyler N. Shendruk

We use continuum simulations to study the impact of anisotropic hydrodynamic friction on the emergent flows of active nematics. We show that, depending on whether the active particles align with or tumble in their collectively self-induced…

Soft Condensed Matter · Physics 2020-03-16 Kristian Thijssen , Luuk Metselaar , Julia M. Yeomans , Amin Doostmohammadi