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In nature interactions between biopolymers and motor proteins give rise to biologically essential emergent behaviours. Besides cytoskeleton mechanics, active nematics arise from such interactions. Here we present a study on 3D active…

In active nematic liquid crystals activity is able to drive chaotic spatiotemporal flows referred to as active turbulence. Active turbulence has been characterized through theoretical and experimental work as a low Reynolds number…

Soft Condensed Matter · Physics 2022-11-30 C. Rorai , F. Toschi , I. Pagonabarraga

Using novel micro-printing techniques, we develop a versatile experimental setup that allows us to study how lateral confinement tames the active flows and defect properties of the microtubule/kinesin active nematic system. We demonstrate…

Hydrodynamic theories effectively describe many-body systems out of equilibrium in terms of a few macroscopic parameters. However, such hydrodynamic parameters are difficult to derive from microscopics. Seldom is this challenge more…

Active nematics are out-of-equilibrium systems in which energy injection at the microscale drives emergent collective behaviors, from spontaneous flows to active turbulence. While the dynamics of these systems have been extensively studied,…

Soft Condensed Matter · Physics 2025-04-15 Ahmet Umut Akduman , Yusuf Sariyar , Giuseppe Negro , Livio Nicola Carenza

We characterize two-dimensional (2D) microtubule-based active nematics driven by light-responsive kinesin motor clusters. We assess two constructs of optogenetic kinesin: opto-K401, a processive motor, and opto-K365, a non-processive motor.…

Soft Condensed Matter · Physics 2023-03-07 Zahra Zarei , John Berezney , Alexander Hensley , Linnea Lemma , Nesrin Senbil , Zvonimir Dogic , Seth Fraden

Active stresses, which are collectively generated by the motion of energy-consuming rod-like constituents, generate chaotic autonomous flows. Controlling active stresses in space and time is an essential prerequisite for controlling the…

Soft Condensed Matter · Physics 2022-09-15 Linnea M. Lemma , Minu Varghese , Tyler D. Ross , Matt Thomson , Aparana Baskaran , Zvonimir Dogic

Recent experiments and numerical studies have drawn attention to the dynamics of active nematics. Two-dimensional active nematics flow spontaneously and exhibit spatiotemporal chaotic flows with proliferation of topological defects in the…

Soft Condensed Matter · Physics 2020-07-08 Farzan Vafa , Mark J. Bowick , M. Cristina Marchetti , Boris I. Shraiman

Active nematic fluids confined in narrow channels generate spontaneous flows when the activity is sufficiently intense. Recently, it was shown that if the molecular anchoring at the channel walls is conflicting flows are initiated even in…

Soft Condensed Matter · Physics 2021-11-02 C. Rorai , F. Toschi , I. Pagonabarraga

We investigate the dynamics of an active gel of bundled microtubules that is driven by clusters of kinesin molecular motors. Upon the addition of ATP, the coordinated action of thousands of molecular motors drives the gel to a highly…

Soft Condensed Matter · Physics 2015-06-23 Gil Henkin , Stephen J. DeCamp , Daniel TN Chen , Tim Sanchez , Zvonimir Dogic

Continuum hydrodynamic models of active liquid crystals have been used to describe dynamic self-organising systems such as bacterial swarms and cytoskeletal gels. A key prediction of such models is the existence of self-stabilising kink…

Soft Condensed Matter · Physics 2009-11-13 S. A. Edwards , J. M. Yeomans

The topological properties of many materials are central to their behavior, with the dynamics of topological defects being particularly important to intrinsically out-of-equilibrium, active materials. In this paper, local manipulation of…

Soft Condensed Matter · Physics 2019-11-01 David P. Rivas , Tyler N. Shendruk , Robert R. Henry , Daniel H. Reich , Robert L. Leheny

Recent experiments on active materials, such as dense bacterial suspensions and microtubule-kinesin motor mixtures, show a promising potential for achieving self-sustained flows. However, to develop active microfluidics it is necessary to…

Soft Condensed Matter · Physics 2019-01-23 Santhan Chandragiri , Amin Doostmohammadi , Julia M Yeomans , Sumesh P Thampi

Cytoskeletal active nematics exhibit striking non-equilibrium dynamics that are powered by energy-consuming molecular motors. To gain insight into the structure and mechanics of these materials, we design programmable clusters in which…

Soft Condensed Matter · Physics 2021-09-15 Alexandra M. Tayar , Michael F. Hagan , Zvonimir Dogic

Active fluids have applications in micromixing, but little is known about the mixing kinematics of systems with spatiotemporally-varying activity. To investigate, UV-activated caged ATP was used to activate controlled regions of…

Soft Condensed Matter · Physics 2022-11-07 Teagan E Bate , Megan E Varney , Ezra H Taylor , Joshua H Dickie , Chih-Che Chueh , Michael M Norton , Kun-Ta Wu

We investigate the turbulent dynamics of a two-dimensional active nematic liquid crystal con- strained on a curved surface. Using a combination of hydrodynamic and particle-based simulations, we demonstrate that the fundamental structural…

Soft Condensed Matter · Physics 2019-05-01 D. J. G. Pearce , Perry W. Ellis , Alberto Fernandez-Nieves , L. Giomi

Active materials are capable of converting free energy into directional motion, giving rise to striking dynamical phenomena. Developing a general understanding of their structure in relation to the underlying non-equilibrium physics would…

Soft Condensed Matter · Physics 2018-10-17 Nitin Kumar , Rui Zhang , Juan J. de Pablo , Margaret L. Gardel

Self-organization of kinesin-driven, microtubule-based 3D active fluids relies on the collective dynamics of single microtubules. However, the connection between macroscopic fluid flows and microscopic motion of microtubules remains…

Soft Condensed Matter · Physics 2019-04-29 Teagan E. Bate , Edward J. Jarvis , Megan E. Varney , Kun-Ta Wu

Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alternatively, harnessing flows from active fluids, which are usually chaotic, has been proposed…

Mixtures of microtubules and molecular motors form active materials with diverse dynamical behaviors that vary based on their constituents' molecular properties. We map the non-equilibrium phase diagram of microtubules and tip-accumulating…

Soft Condensed Matter · Physics 2021-08-04 Bezia Lemma , Noah P. Mitchell , Radhika Subramanian , Daniel J. Needleman , Zvonimir Dogic
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