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This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models…

For constructing neuronal network models computational neuroscientists have access to wide-ranging anatomical data that nevertheless tend to cover only a fraction of the parameters to be determined. Finding and interpreting the most…

To learn how cognition is implemented in the brain, we must build computational models that can perform cognitive tasks, and test such models with brain and behavioral experiments. Cognitive science has developed computational models of…

Neurons and Cognition · Quantitative Biology 2018-08-01 Nikolaus Kriegeskorte , Pamela K. Douglas

The interactions play one of the central roles in the brain mediating various processes and functions. They are particularly important for the brain as a complex system that has many different functions from the same structural…

Adaptation and Self-Organizing Systems · Physics 2020-08-19 Tomislav Stankovski

It has been said that complexity lies between order and disorder. In the case of brain activity, and physiology in general, complexity issues are being considered with increased emphasis. We sought to identify features of brain organization…

Neurons and Cognition · Quantitative Biology 2017-01-11 R. Guevara Erra , D. M. Mateos , R. Wennberg , J. L. Perez Velazquez

Neuroscience is undergoing dramatic progress because of the vast data streams derived from the new technologies product of the BRAIN initiative and other enterprises. As any other scientific field, neuroscience benefits from having clear…

Neurons and Cognition · Quantitative Biology 2022-09-22 Horacio G. Rotstein , Fidel Santamaria

Brain can be represented as a network, where regions are the nodes and relations between the regions are edges. Within a network, co-existence of cooperative and competitive relationships between different nodes is called coopetition.…

Neurons and Cognition · Quantitative Biology 2018-02-13 Subhadip Paul , Satyam Mukherjee , Sagnik Bhattacharyya

A fundamental question in neuroscience is how structure and function of neural systems are related. We study this interplay by combining a familiar auto-associative neural network with an evolving mechanism for the birth and death of…

Adaptation and Self-Organizing Systems · Physics 2019-04-26 Ana P. Millán , J. J. Torres , S. Johnson , J. Marro

In neural networks with identical neurons, the matrix of connection weights completely describes the network structure and thereby determines how it is processing information. However, due to the non-linearity of these systems, it is not…

Neurons and Cognition · Quantitative Biology 2018-11-14 Patrick Krauss , Alexandra Zankl , Achim Schilling , Holger Schulze , Claus Metzner

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

Graph theoretical approach has proved an effective tool to understand, characterize and quantify the complex brain network. However, much less attention has been paid to methods that quantitatively compare two graphs, a crucial issue in the…

Neurons and Cognition · Quantitative Biology 2019-08-29 Ahmad Mheich , Fabrice Wendling , Mahmoud Hassan

The cerebral cortex is composed of multiple cortical areas that exert a wide variety of brain functions. Although human brain neurons are genetically and areally mosaic, the three-dimensional structural differences between neurons in…

Structural connectivity in the brain is typically studied by reducing its observation to a single spatial resolution. However, the brain possesses a rich architecture organized over multiple scales linked to one another. We explored the…

Physics and Society · Physics 2020-09-07 Muhua Zheng , Antoine Allard , Patric Hagmann , Yasser Alemán-Gómez , M. Ángeles Serrano

It has become increasingly popular to study the brain as a network due to the realization that functionality cannot be explained exclusively by independent activation of specialized regions. Instead, across a large spectrum of behaviors,…

Neurons and Cognition · Quantitative Biology 2014-07-22 Petko Bogdanov , Nazli Dereli , Danielle S. Bassett , Scott T. Grafton , Ambuj K. Singh

The contribution of structural connectivity to functional brain states remains poorly understood. We present a mathematical and computational study suited to assess the structure--function issue, treating a system of Jansen--Rit neural-mass…

Neurons and Cognition · Quantitative Biology 2020-07-10 Michael Forrester , Stephen Coombes , Jonathan J. Crofts , Stamatios N. Sotiropoulos , Reuben D. O'Dea

The structure of the axon-dendrite connections of neurons of the brain creates a rich spatial structure in which provided various combinations of signals surrounding neurons. Structure of dendritic trees and shape of dendritic spines allow…

Artificial Intelligence · Computer Science 2014-07-25 Alexey Redozubov

A pressing scientific challenge is to understand how brains work. Of particular interest is the neocortex,the part of the brain that is especially large in humans, capable of handling a wide variety of tasks including visual, auditory,…

Neural and Evolutionary Computing · Computer Science 2016-09-03 Peter U. Diehl , Matthew Cook

Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain structure? Using a hydrodynamic description for cell nuclei as particles interacting initially via an effective,…

Soft Condensed Matter · Physics 2021-12-15 Ahmad Borzou , J. M. Schwarz

There is growing interest in understanding how the structural interconnections among brain regions change with the occurrence of neurological diseases. Diffusion weighted MRI imaging has allowed researchers to non-invasively estimate a…

Applications · Statistics 2015-10-20 Daniele Durante , Madelaine Daianu , Neda Jahanshad , Paul M. Thompson , David B. Dunson

A central idea in understanding brains and building artificial intelligence is that structure determines function. Yet, how the brain's complex structure arises from a limited set of genetic instructions remains a key question. The ultra…

Neurons and Cognition · Quantitative Biology 2026-01-28 Xingyu Liu , Yubin Li , Guozhang Chen