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Over 15 million epilepsy patients worldwide do not respond to drugs and require surgical treatment. Successful surgical treatment requires complete removal, or disconnection of the epileptogenic zone (EZ), but without a prospective…

Machine Learning · Computer Science 2022-02-16 Adam Li , Chester Huynh

Epilepsy is a network disease. The epileptic network usually involves spatially distributed brain regions. In this context, noninvasive M/EEG source connectivity is an emerging technique to identify functional brain networks at cortical…

Neurons and Cognition · Quantitative Biology 2016-08-18 Mahmoud Hassan , Isabelle Merlet , Ahmad Mheich , Aya Kabbara , Arnaud Biraben , Anca Nica , Fabrice Wendling

Pathophysiolpgical modelling of brain systems from microscale to macroscale remains difficult in group comparisons partly because of the infeasibility of modelling the interactions of thousands of neurons at the scales involved. Here, to…

Neurons and Cognition · Quantitative Biology 2026-01-30 Kang You , Gary Green , Jian Zhang

Background and Objectives: Many biological processes are modulated by rhythms on circadian and multidien timescales. In focal epilepsy, various seizure features, such as spread and duration, can change from one seizure to the next within…

Epilepsy is a common neurological disorder characterized by recurrent seizures accompanied by excessive synchronous brain activity. The process of structural and functional brain alterations leading to increased seizure susceptibility and…

Signal Processing · Electrical Eng. & Systems 2020-06-18 Diyuan Lu , Sebastian Bauer , Valentin Neubert , Lara Sophie Costard , Felix Rosenow , Jochen Triesch

Epilepsy represents the most prevalent neurological disease in the world. One-third of people suffering from mesial temporal lobe epilepsy (MTLE) exhibit drug resistance, urging the need to develop new treatments. A key part in anti-seizure…

Insomnia affects a vast population of the world and can have a wide range of causes. Existing treatments for insomnia have been linked with many side effects like headaches, dizziness, etc. As such, there is a clear need for improved…

Signal Processing · Electrical Eng. & Systems 2025-07-22 Kevin Monteiro , Sam Nallaperuma-Herzberg , Martina Mason , Steve Niederer

We explore the use of neural networks trained with dropout in predicting epileptic seizures from electroencephalographic data (scalp EEG). The input to the neural network is a 126 feature vector containing 9 features for each of the 14 EEG…

Machine Learning · Computer Science 2019-02-05 Siddharth Pramod , Adam Page , Tinoosh Mohsenin , Tim Oates

EEG-correlated fMRI analysis is widely used to detect regional blood oxygen level dependent fluctuations that are significantly synchronized to interictal epileptic discharges, which can provide evidence for localizing the ictal onset zone.…

Signal Processing · Electrical Eng. & Systems 2020-05-04 Simon Van Eyndhoven , Patrick Dupont , Simon Tousseyn , Nico Vervliet , Wim Van Paesschen , Sabine Van Huffel , Borbála Hunyadi

Epilepsy is one of the most occurring neurological disease globally emerged back in 4000 BC. It is affecting around 50 million people of all ages these days. The trait of this disease is recurrent seizures. In the past few decades, the…

Machine Learning · Computer Science 2021-11-08 Virender Ranga , Shivam Gupta , Jyoti Meena , Priyansh Agrawal

Seizure prediction has attracted a growing attention as one of the most challenging predictive data analysis efforts in order to improve the life of patients living with drug-resistant epilepsy and tonic seizures. Many outstanding works…

Computer Vision and Pattern Recognition · Computer Science 2017-12-07 Nhan Duy Truong , Anh Duy Nguyen , Levin Kuhlmann , Mohammad Reza Bonyadi , Jiawei Yang , Omid Kavehei

The study of dynamical systems defined on complex networks provides a natural framework with which to investigate myriad features of neural dynamics, and has been widely undertaken. Typically, however, networks employed in theoretical…

Neurons and Cognition · Quantitative Biology 2013-02-22 Reuben O'Dea , Jonathan J. Crofts , Marcus Kaiser

Real time seizure detection is a fundamental problem in computational neuroscience towards diagnosis and treatment's improvement of epileptic disease. We propose a real-time computational method for tracking and detection of epileptic…

Quantitative Methods · Quantitative Biology 2024-06-17 Ximena Fernández , Diego Mateos

During clinical treatment for epilepsy, the area of the brain thought to be responsible for pathological activity is identified. This identification is typically performed through visual assessment of EEG recordings; however, this is time…

Empirical studies over the past two decades have supported the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically-mediated…

Neurons and Cognition · Quantitative Biology 2013-06-28 Felix Siebenhuhner , Shennan A. Weiss , Richard Coppola , Daniel R. Weinberger , Danielle S. Bassett

In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (STAN) for accurate predictions of onset of seizures for Epilepsy…

Signal Processing · Electrical Eng. & Systems 2025-11-06 Zan Li , Kyongmin Yeo , Wesley Gifford , Lara Marcuse , Madeline Fields , Bülent Yener

Intracranial recordings in epilepsy patients are increasingly utilized to gain insight into the electrophysiological mechanisms of human cognition. There are currently several practical limitations to conducting research with these…

Neurons and Cognition · Quantitative Biology 2021-06-23 Omer E Ashmaig , Liberty S Hamilton , Pradeep Modur , Robert J Buchanan , Alison R Preston , Andrew J Watrous

Recently, the potential of dynamic brain networks as a neuroimaging biomarkers for mental illnesses is being increasingly recognized. However, there are several unmet challenges in developing such biomarkers, including the need for methods…

Neurons and Cognition · Quantitative Biology 2019-10-10 Suprateek Kundu , Jin Ming , Jennifer Stevens

Epilepsy is a chronic neurological disorder that affects a significant portion of the human population and imposes serious risks in the daily life of patients. Despite advances in machine learning and IoT, small, nonstigmatizing wearable…

Machine Learning · Computer Science 2023-02-22 Una Pale , Tomas Teijeiro , David Atienza

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo
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