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In the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug…

Quantitative Methods · Quantitative Biology 2024-09-23 Nazanin Ahmadi Daryakenari , Shupeng Wang , George Karniadakis

Exact calculation of electronic properties of molecules is a fundamental step for intelligent and rational compounds and materials design. The intrinsically graph-like and non-vectorial nature of molecular data generates a unique and…

Chemical Physics · Physics 2019-10-29 Alain Tchagang , Julio Valdés

Most chemical processes, such as distillation, absorption, extraction, and catalytic reactions, are extremely complex processes that are affected by multiple factors. The relationships between their input variables and output variables are…

Systems and Control · Electrical Eng. & Systems 2021-10-19 Li Sun , Fei Liang , Wutai Cui

We assess the predictive power of alchemical perturbations for estimating fundamental properties in ionic crystals. Using density functional theory we have calculated formation energies, lattice constants, and bulk moduli for all sixteen…

Chemical Physics · Physics 2016-05-27 Alisa Solovyeva , O. Anatole von Lilienfeld

Computing atomic-scale properties of chemically disordered materials requires an efficient exploration of their vast configuration space. Traditional approaches such as Monte Carlo or Special Quasirandom Structures either entail sampling an…

Materials Science · Physics 2026-03-17 Maciej J. Karcz , Luca Messina , Eiji Kawasaki , Emeric Bourasseau

We present our findings of a large-scale screening for new synthesizable materials in five M-Sn binaries, M = Na, Ca, Cu, Pd, and Ag. The focus on these systems was motivated by the known richness of M-Sn properties with potential…

Materials Science · Physics 2025-07-10 Aidan Thorn , Daviti Gochitashvili , Saba Kharabadze , Aleksey N. Kolmogorov

Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have mainly relied on emulating…

Machine Learning · Computer Science 2025-09-23 Rajiv Teja Nagipogu , John H. Reif

Doping compounds can be considered a perturbation to the nuclear charges in a molecular Hamiltonian. Expansions of this perturbation in a Taylor series, i.e. quantum alchemy, has been used in literature to assess millions of derivative…

Chemical Physics · Physics 2024-06-19 Guido Falk von Rudorff

High-throughput computational screening has emerged as a critical component of materials discovery. Direct density functional theory (DFT) simulation of inorganic materials and molecular transition metal complexes is often used to describe…

Materials Science · Physics 2017-05-18 Jon Paul Janet , Heather J. Kulik

Dopamine levels are linked to neurological illnesses like Parkinson's and Alzheimer's. Thus, reliable and sensitive detection of dopamine is crucial for early diagnosis and surveillance of neurodegenerative diseases. Non-noble-metal-based…

Artificial Neural Networks (ANN) have been popularized in many science and technological areas due to their capacity to solve many complex pattern matching problems. That is the case of Virtual Screening, a research area that studies how to…

Neural and Evolutionary Computing · Computer Science 2020-06-05 Christian F. Frasser , Carola de Benito , Vincent Canals , Miquel Roca , Pedro J. Ballester , Josep L. Rossello

Localized basis ab initio molecular dynamics simulation within the density functional framework has been used to generate realistic configurations of amorphous silicon carbide (a-SiC). Our approach consists of constructing a set of smart…

Disordered Systems and Neural Networks · Physics 2015-05-13 Raymond Atta-Fynn , Parthapratim Biswas

Local chemical ordering strongly influences the behavior of complex concentrated alloys, yet its characterization remains challenging due to the nanoscale dimensions and scattered spatial distribution of the ordered domains. Here, we study…

Materials Science · Physics 2026-02-10 Ian Geiger , Yuan Tian , Ying Han , Yutong Bi , Xiaoqing Pan , Penghui Cao , Timothy J. Rupert

Supervised deep learning techniques show promise in medical image analysis. However, they require comprehensive annotated data sets, which poses challenges, particularly for rare diseases. Consequently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Finn Behrendt , Debayan Bhattacharya , Lennart Maack , Julia Krüger , Roland Opfer , Robin Mieling , Alexander Schlaefer

Analysing two-dimensional shallow water equations with idealised bottom topographies have many applications in the atmospheric and oceanic sciences; however, restrictive flow pattern assumptions have been made to achieve explicit solutions.…

Fluid Dynamics · Physics 2023-05-01 Chang Liu , Antwan D. Clark

Grain boundaries (GBs) are planar lattice defects that govern the properties of many types of polycrystalline materials. Hence, their structures have been investigated in great detail. However, much less is known about their chemical…

Determining the stability of molecules and condensed phases is the cornerstone of atomistic modelling, underpinning our understanding of chemical and materials properties and transformations. Here we show that a machine learning model,…

Accurate classification of molecular chemical motifs from experimental measurement is an important problem in molecular physics, chemistry and biology. In this work, we present neural network ensemble classifiers for predicting the presence…

Materials Science · Physics 2023-06-29 Matthew R. Carbone , Phillip M. Maffettone , Xiaohui Qu , Shinjae Yoo , Deyu Lu

The traditional display of elements in the periodic table is convenient for the study of chemistry and physics. However, the atomic number alone is insufficient for training statistical machine learning models to describe and extract…

Materials Science · Physics 2023-08-25 Anthony Onwuli , Ashish V. Hegde , Kevin Nguyen , Keith T. Butler , Aron Walsh

Modeling atmospheric chemistry is complex and computationally intense. Given the recent success of Deep neural networks in digital signal processing, we propose a Neural Network Emulator for fast chemical concentration modeling. We consider…

Machine Learning · Computer Science 2025-01-16 Zhi-Song Liu , Petri Clusius , Michael Boy