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Estimating brain age (BA) from T1-weighted magnetic resonance images (MRIs) provides a powerful framework for quantifying anatomical brain aging. Whereas global BA (GBA) summarizes overall brain health, local BA (LBA) provides cortically…

The correlation matrix is a central representation of functional brain networks in neuroimaging. Traditional analyses often treat pairwise interactions independently in a Euclidean setting, overlooking the intrinsic geometry of correlation…

Machine Learning · Statistics 2025-04-10 Kisung You , Yelim Lee , Hae-Jeong Park

Motivated by the analysis of high-dimensional neuroimaging signals located over the cortical surface, we introduce a novel Principal Component Analysis technique that can handle functional data located over a two-dimensional manifold. For…

Applications · Statistics 2019-08-02 Eardi Lila , John A. D. Aston , Laura M. Sangalli

Automatic segmentation of brain MR images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is critical for tissue volumetric analysis and cortical surface reconstruction. Due to dramatic structural and appearance…

Image and Video Processing · Electrical Eng. & Systems 2023-01-05 Xiaoyang Chen , Jinjian Wu , Wenjiao Lyu , Yicheng Zou , Kim-Han Thung , Siyuan Liu , Ye Wu , Sahar Ahmad , Pew-Thian Yap

Neurodegeneration affects cortical gray matter leading to loss of cortical mantle volume. As a result of such volume loss, the geometrical arrangement of the regions on the cortical surface is expected to be altered in comparison to healthy…

Neurons and Cognition · Quantitative Biology 2016-11-16 Amanmeet Garg , Donghuan Lu , Karteek Popuri , Mirza Faisal Beg

Advances in image registration and machine learning have recently enabled volumetric analysis of postmortem brain tissue from conventional photographs of coronal slabs, which are routinely collected in brain banks and neuropathology…

The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

In Functional Data Analysis, data are commonly assumed to be smooth functions on a fixed interval of the real line. In this work, we introduce a comprehensive framework for the analysis of functional data, whose domain is a two-dimensional…

Methodology · Statistics 2019-08-02 Eardi Lila , John A. D. Aston

Neuromorphology is crucial to identifying neuronal subtypes and understanding learning. It is also implicated in neurological disease. However, standard morphological analysis focuses on macroscopic features such as branching frequency and…

Neurons and Cognition · Quantitative Biology 2022-03-10 Thomas L. Athey , Jacopo Teneggi , Joshua T. Vogelstein , Daniel Tward , Ulrich Mueller , Michael I. Miller

Linear models are widely used in computational neuroimaging to identify biomarkers associated with brain pathologies. However, interpreting the learned weights remains challenging, as they do not always yield clinically meaningful insights.…

Machine Learning · Computer Science 2026-04-23 Sara Petiton , Antoine Grigis , Raphaël Vock , Edouard Duchesnay

In this paper, we present a novel method for analysis and segmentation of laminar structure of the cortex based on tissue characteristics whose change across the gray matter underlies distinctive between cortical layers. We develop and…

Computer Vision and Pattern Recognition · Computer Science 2019-12-16 Andrija Štajduhar , Tomislav Lipić , Goran Sedmak , Sven Lončarić , Miloš Judaš

State-of-the-art methods for quantifying wear in cylinder liners of large internal combustion engines require disassembly and cutting of the liner. This is followed by laboratory-based high-resolution microscopic surface depth measurement…

Unsupervised anomaly detection in brain imaging is challenging. In this paper, we propose self-supervised masked mesh learning for unsupervised anomaly detection on 3D cortical surfaces. Our framework leverages the intrinsic geometry of the…

Image and Video Processing · Electrical Eng. & Systems 2025-04-01 Hao-Chun Yang , Sicheng Dai , Saige Rutherford , Christian Gaser , Andre F Marquand , Christian F Beckmann , Thomas Wolfers

In this paper we propose a deep learning approach for segmenting sub-cortical structures of the human brain in Magnetic Resonance (MR) image data. We draw inspiration from a state-of-the-art Fully-Convolutional Neural Network (F-CNN)…

Computer Vision and Pattern Recognition · Computer Science 2016-02-08 Mahsa Shakeri , Stavros Tsogkas , Enzo Ferrante , Sarah Lippe , Samuel Kadoury , Nikos Paragios , Iasonas Kokkinos

Non-rigid cortical registration is an important and challenging task due to the geometric complexity of the human cortex and the high degree of inter-subject variability. A conventional solution is to use a spherical representation of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-28 Jieyu Cheng , Adrian V. Dalca , Bruce Fischl , Lilla Zollei

Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic…

Image and Video Processing · Electrical Eng. & Systems 2024-09-09 Karthik Gopinath , Douglas N. Greve , Colin Magdamo , Steve Arnold , Sudeshna Das , Oula Puonti , Juan Eugenio Iglesias

Brain extraction from images is a common pre-processing step. Many approaches exist, but they are frequently only designed to perform brain extraction from images without strong pathologies. Extracting the brain from images with strong…

Computer Vision and Pattern Recognition · Computer Science 2018-05-10 Xu Han , Roland Kwitt , Stephen Aylward , Spyridon Bakas , Bjoern Menze , Alexander Asturias , Paul Vespa , John Van Horn , Marc Niethammer

Conventional visualization media such as MRI prints and computer screens are inherently two dimensional, making them incapable of displaying true 3D volume data sets. By applying only transparency or intensity projection, and ignoring…

Graphics · Computer Science 2007-05-23 Gibby Koldenhof

We consider the problem of finding an accurate representation of neuron shapes, extracting sub-cellular features, and classifying neurons based on neuron shapes. In neuroscience research, the skeleton representation is often used as a…

Computer Vision and Pattern Recognition · Computer Science 2022-12-15 Jiaxiang Jiang , Michael Goebel , Cezar Borba , William Smith , B. S. Manjunath

The shapes and morphology of the organs and tissues are important prior knowledge in medical imaging recognition and segmentation. The morphological operation is a well-known method for morphological feature extraction. As the morphological…

Computer Vision and Pattern Recognition · Computer Science 2021-03-09 Chentian Li , Chi Ma , William W. Lu