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Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically consider a limited number of hypotheses, most of which are…

Genomics · Quantitative Biology 2007-05-23 Zhong Li , Aris Floratos , David Wang , Andrea Califano

An increasing number of large-scale multi-modal research initiatives has been conducted in the typically developing population, as well as in psychiatric cohorts. Missing data is a common problem in such datasets due to the difficulty of…

This paper presents methods which are aimed at finding approximations to missing data in a dataset by using optimization algorithms to optimize the network parameters after which prediction and classification tasks can be performed. The…

Neural and Evolutionary Computing · Computer Science 2014-03-24 Collins Leke , Bhekisipho Twala , T. Marwala

Autism Spectrum Disorder (ASD) is a chronic neurodevelopmental condition characterized by repetitive behaviors and impairments in social and communication skills. Despite the clear manifestation of these symptoms, many individuals with ASD…

Machine Learning · Computer Science 2026-01-27 Aneesh Panchal , Kainat Khan , Rahul Katarya

Logistic regression is a fundamental and widely used statistical method for modeling binary outcomes based on covariates. However, the presence of missing data, particularly in settings involving hybrid covariates (a mix of discrete and…

Methodology · Statistics 2025-06-05 Mohamed Cherifi , Xujia Zhu , Mohammed Nabil El Korso , Ammar Mesloub

Modern disease classification often overlooks molecular commonalities hidden beneath divergent clinical presentations. This study introduces a transcriptomics-driven framework for discovering disease relationships by analyzing over 1300…

Genomics · Quantitative Biology 2025-08-08 Ke Chen , Haohan Wang

Using predictive models to identify patterns that can act as biomarkers for different neuropathoglogical conditions is becoming highly prevalent. In this paper, we consider the problem of Autism Spectrum Disorder (ASD) classification where…

Machine Learning · Statistics 2018-10-31 Rushil Anirudh , Jayaraman J. Thiagarajan

Logistic regression is a common classification method in supervised learning. Surprisingly, there are very few solutions for performing logistic regression with missing values in the covariates. We suggest a complete approach based on a…

Methodology · Statistics 2019-08-09 Wei Jiang , Julie Josse , Marc Lavielle , TraumaBase Group

Anomaly detection in time series data, to identify points that deviate from normal behaviour, is a common problem in various domains such as manufacturing, medical imaging, and cybersecurity. Recently, Generative Adversarial Networks (GANs)…

Machine Learning · Computer Science 2025-05-27 Md Abul Bashar , Richi Nayak

Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease…

Machine Learning · Computer Science 2013-10-17 Shandian Zhe , Zenglin Xu , Yuan Qi

Clustering has long been a popular unsupervised learning approach to identify groups of similar objects and discover patterns from unlabeled data in many applications. Yet, coming up with meaningful interpretations of the estimated clusters…

Methodology · Statistics 2020-05-26 Minjie Wang , Tianyi Yao , Genevera I. Allen

In statistics and machine learning, logistic regression is a widely-used supervised learning technique primarily employed for binary classification tasks. When the number of observations greatly exceeds the number of predictor variables, we…

Machine Learning · Statistics 2024-04-02 Agniva Chowdhury , Pradeep Ramuhalli

Gallstone disease is a complex, multifactorial condition with significant global health burdens. Identifying underlying risk factors and their interactions is crucial for early diagnosis, targeted prevention, and effective clinical…

Applications · Statistics 2025-06-18 Chitradipa Chakraborty , Nayana Mukherjee

Mental disorders such as Autism Spectrum Disorders (ASD) are heterogeneous disorders that are notoriously difficult to diagnose, especially in children. The current psychiatric diagnostic process is based purely on the behavioural…

Machine Learning · Computer Science 2019-04-17 Taban Eslami , Vahid Mirjalili , Alvis Fong , Angela Laird , Fahad Saeed

Community detection is an important content in complex network analysis. The existing community detection methods in attributed networks mostly focus on only using network structure, while the methods of integrating node attributes is…

Social and Information Networks · Computer Science 2023-09-01 Xiao Wang , Fang Dai , Wenyan Guo , Junfeng Wang

As one of the most popular statistical and machine learning models, logistic regression with regularization has found wide adoption in biomedicine, social sciences, information technology, and so on. These domains often involve data of…

Machine Learning · Computer Science 2016-09-28 Wenfa Li , Hongzhe Liu , Peng Yang , Wei Xie

Clustering of gene expression time series gives insight into which genes may be coregulated, allowing us to discern the activity of pathways in a given microarray experiment. Of particular interest is how a given group of genes varies with…

Quantitative Methods · Quantitative Biology 2018-02-13 Muhammad Arifur Rahman , Paul R. Heath , Neil D. Lawrence

The problem of community detection receives great attention in recent years. Many methods have been proposed to discover communities in networks. In this paper, we propose a Gaussian stochastic blockmodel that uses Gaussian distributions to…

Social and Information Networks · Computer Science 2015-03-19 Junhao Zhang , Tongfei Chen , Junfeng Hu

Graph neural networks (GNN) are a powerful tool for combining imaging and non-imaging medical information for node classification tasks. Cross-network node classification extends GNN techniques to account for domain drift, allowing for node…

Social and Information Networks · Computer Science 2024-01-12 Anna Stephens , Francisco Santos , Pang-Ning Tan , Abdol-Hossein Esfahanian

The stochastic block model is one of the most studied network models for community detection. It is well-known that most algorithms proposed for fitting the stochastic block model likelihood function cannot scale to large-scale networks.…

Methodology · Statistics 2021-08-31 Jiangzhou Wang , Jingfei Zhang , Binghui Liu , Ji Zhu , Jianhua Guo