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Identification of disease genes, which are a set of genes associated with a disease, plays an important role in understanding and curing diseases. In this paper, we present a biomedical knowledge graph designed specifically for this…

In traditional logistic regression models, the link function is often assumed to be linear and continuous in predictors. Here, we consider a threshold model that all continuous features are discretized into ordinal levels, which further…

Methodology · Statistics 2022-02-18 Yinan Lin , Wen Zhou , Zhi Geng , Gexin Xiao , Jianxin Yin

Stochastic block models (SBMs) are often used to find assortative community structures in networks, such that the probability of connections within communities is higher than in between communities. However, classic SBMs are not limited to…

Social and Information Networks · Computer Science 2020-04-27 Daniel Gribel , Thibaut Vidal , Michel Gendreau

Generalized linear regressions, such as logistic regressions or Poisson regressions, are long-studied regression analysis approaches, and their applications are widely employed in various classification problems. Our study considers a…

Machine Learning · Statistics 2024-01-17 Vu Duc Anh , Tran Anh Tuan , Tran Ngoc Thang , Nguyen Thi Ngoc Anh

Autism Spectrum Disorder (ASD) is often underdiagnosed in females due to gender-specific symptom differences overlooked by conventional diagnostics. This study evaluates machine learning models, particularly Random Forest and convolutional…

Computer Vision and Pattern Recognition · Computer Science 2024-11-12 Mohammed Aledhari , Mohamed Rahouti , Ali Alfatemi

Risk for autism can be influenced by genetic mutations in hundreds of genes. Based on findings showing that genes with highly correlated gene expressions are functionally interrelated, "guilt by association" methods such as DAWN have been…

Methodology · Statistics 2020-03-10 Kevin Z. Lin , Han Liu , Kathryn Roeder

This work proposes a unified framework to leverage biological information in network propagation-based gene prioritization algorithms. Preliminary results on breast cancer data show significant improvements over state-of-the-art baselines,…

Molecular Networks · Quantitative Biology 2020-02-18 Michele Gentili , Leonardo Martini , Manuela Petti , Lorenzo Farina , Luca Becchetti

The preclinical stage of many neurodegenerative diseases can span decades before symptoms become apparent. Understanding the sequence of preclinical biomarker changes provides a critical opportunity for early diagnosis and effective…

Methodology · Statistics 2024-06-11 Yizhen Xu , Scott Zeger , Zheyu Wang

Universities face surging applications and heightened expectations for fairness, making accurate admission prediction increasingly vital. This work presents a comprehensive framework that fuses machine learning, deep learning, and large…

Computers and Society · Computer Science 2025-09-29 Mohammad Abbadi , Yassine Himeur , Shadi Atalla , Dahlia Mansoor , Wathiq Mansoor

Many complex disease syndromes such as asthma consist of a large number of highly related, rather than independent, clinical phenotypes, raising a new technical challenge in identifying genetic variations associated simultaneously with…

Machine Learning · Statistics 2008-11-16 Seyoung Kim , Kyung-Ah Sohn , Eric P. Xing

Anomaly detection is a relevant problem in the area of data analysis. In networked systems, where individual entities interact in pairs, anomalies are observed when pattern of interactions deviates from patterns considered regular. Properly…

Social and Information Networks · Computer Science 2023-10-25 Hadiseh Safdari , Caterina De Bacco

Detecting system anomalies based on log data is important for ensuring the security and reliability of computer systems. Recently, deep learning models have been widely used for log anomaly detection. The core idea is to model the log…

Machine Learning · Computer Science 2023-12-12 Xiao Han , Shuhan Yuan , Mohamed Trabelsi

Logistic regression models are a popular and effective method to predict the probability of categorical response data. However inference for these models can become computationally prohibitive for large datasets. Here we adapt ideas from…

Methodology · Statistics 2020-08-25 Tom Whitaker , Boris Beranger , Scott A. Sisson

Dealing with imbalanced data is one of the main challenges in machine/deep learning algorithms for classification. This issue is more important with log message data as it is typically very imbalanced and negative logs are rare. In this…

Machine Learning · Computer Science 2020-06-16 Amir Farzad , T. Aaron Gulliver

We consider the problem of fast time-series data clustering. Building on previous work modeling the correlation-based Hamiltonian of spin variables we present an updated fast non-expensive Agglomerative Likelihood Clustering algorithm…

Computational Finance · Quantitative Finance 2022-03-22 Lionel Yelibi , Tim Gebbie

Many neural networks deployed in the real world scenarios are trained using cross entropy based loss functions. From the optimization perspective, it is known that the behavior of first order methods such as gradient descent crucially…

Machine Learning · Computer Science 2023-10-09 Zhu Wang , Praveen Raj Veluswami , Harsh Mishra , Sathya N. Ravi

We consider the problem of estimating common community structures in multi-layer stochastic block models, where each single layer may not have sufficient signal strength to recover the full community structure. In order to efficiently…

Statistics Theory · Mathematics 2022-03-08 Jing Lei , Kevin Z. Lin

We propose a new and computationally efficient algorithm for maximizing the observed log-likelihood for a multivariate normal data matrix with missing values. We show that our procedure based on iteratively regressing the missing on the…

Methodology · Statistics 2012-11-21 Nicolas Städler , Daniel J. Stekhoven , Peter Bühlmann

Anomaly detection is the process of finding data points that deviate from a baseline. In a real-life setting, anomalies are usually unknown or extremely rare. Moreover, the detection must be accomplished in a timely manner or the risk of…

Machine Learning · Computer Science 2019-04-26 Mariem Ben Fadhel , Kofi Nyarko

Logistic regression is among the most widely used statistical methods for linear discriminant analysis. In many applications, we only observe possibly mislabeled responses. Fitting a conventional logistic regression can then lead to biased…

Applications · Statistics 2017-02-21 Hung Hung , Zhi-Yu Jou , Su-Yun Huang
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