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The advent of large-scale and high-density extracellular recording devices allows simultaneous recording from thousands of neurons. However, the complexity and size of the data makes it mandatory to develop robust algorithms for fully…

Neurons and Cognition · Quantitative Biology 2019-12-03 Gerrit Hilgen

Decoding extracellular recordings is a crucial task in electrophysiology and brain-computer interfaces. Spike sorting, which distinguishes spikes and their putative neurons from extracellular recordings, becomes computationally demanding…

Signal Processing · Electrical Eng. & Systems 2024-12-31 Yuntao Han , Shiwei Wang

This paper deals with the problem of extracting the activity of individual neurons from multi-electrode recordings. Important aspects of this work are: 1) the sorting is done in two stages - a statistical model of the spikes from different…

Data Analysis, Statistics and Probability · Physics 2007-05-23 Dima Rinberg , William Bialek , Hanan Davidowitz , Naftali Tishby

Estimating neuron location from extracellular recordings is essential for developing advanced brain-machine interfaces. Accurate neuron localization improves spike sorting, which involves detecting action potentials and assigning them to…

Neurons and Cognition · Quantitative Biology 2025-08-20 Hao Zhao , Xinhe Zhang , Arnau Marin-Llobet , Xinyi Lin , Jia Liu

Spike sorting is an essential process in neural recording, which identifies and separates electrical signals from individual neurons recorded by electrodes in the brain, enabling researchers to study how specific neurons communicate and…

Neurons and Cognition · Quantitative Biology 2025-12-23 Yimu Zhang , Dongqi Han , Yansen Wang , Zhenning Lv , Yu Gu , Dongsheng Li

Spikes in the membrane electrical potentials of neurons play a major role in the functioning of nervous systems of animals. Obtaining the spikes from different neurons has been a challenging problem for decades. Several schemes have been…

Quantitative Methods · Quantitative Biology 2016-02-11 Anupam Mitra , Anagh Pathak , Kaushik Majumdar

Extracellular recordings with multi-electrode arrays is one of the basic tools of contemporary neuroscience. These recordings are mostly used to monitor the activities, understood as sequences of emitted action potentials, of many…

Computational Engineering, Finance, and Science · Computer Science 2014-12-22 Christophe Pouzat , Georgios Is. Detorakis

Objective: Spike sorting is a fundamental step in analysing extracellular recordings, enabling the isolation of single-neuron activity. However, it remains a challenging problem because extracellular traces mix overlapping spikes from…

Signal Processing · Electrical Eng. & Systems 2025-06-12 Vasileios Georgiadis , Panagiotis C. Petrantonakis

Spike sorting refers to the problem of assigning action potentials observed in extra-cellular recordings of neural activity to the neuron(s) from which they originate. We cast this problem as one of learning a convolutional dictionary from…

Methodology · Statistics 2018-06-07 Andrew H. Song , Francisco Flores , Demba Ba

We propose a construction for joint feature learning and clustering of multichannel extracellular electrophysiological data across multiple recording periods for action potential detection and discrimination ("spike sorting"). Our…

Developing electrophysiological recordings of brain neuronal activity and their analysis provide a basis for exploring the structure of brain function and nervous system investigation. The recorded signals are typically a combination of…

Neurons and Cognition · Quantitative Biology 2019-11-01 Sahar Hojjatinia , Constantino M. Lagoa

Determining the positions of neurons in an extracellular recording is useful for investigating functional properties of the underlying neural circuitry. In this work, we present a Bayesian modelling approach for localizing the source of…

Neurons and Cognition · Quantitative Biology 2022-01-28 Cole L. Hurwitz , Kai Xu , Akash Srivastava , Alessio P. Buccino , Matthias H. Hennig

Spike sorting is a critical process for decoding large-scale neural activity from extracellular recordings. The advancement of neural probes facilitates the recording of a high number of neurons with an increase in channel counts, arising a…

Signal Processing · Electrical Eng. & Systems 2025-01-31 Yuntao Han , Yihan Pan , Xiongfei Jiang , Cristian Sestito , Shady Agwa , Themis Prodromakis , Shiwei Wang

An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single unit activity from the recorded multi unit signal. To identify single units (SUs), potential spikes are detected and…

Neurons and Cognition · Quantitative Biology 2018-11-01 Jeyathevy Sukiban , Nicole Voges , Till A. Dembek , Robin Pauli , Michael Denker , Immo Weber , Lars Timmermann , Sonja Grün

Human brain neuron activities are incredibly significant nowadays. Neuronal behavior is assessed by analyzing signal data such as electroencephalography (EEG), which can offer scientists valuable information about diseases and…

Objective. Spike sorting, a critical step in neural data processing, aims to classify spiking events from single electrode recordings based on different waveforms. This study aims to develop a novel online spike sorter, NeuSort, using…

Neural and Evolutionary Computing · Computer Science 2023-09-19 Hang Yu , Yu Qi , Gang Pan

We present an algorithm to identify individual neural spikes observed on high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers of distinct neural units, even when spikes overlap, and accounts for intrinsic…

Neurons and Cognition · Quantitative Biology 2013-08-01 Jason S. Prentice , Jan Homann , Kristina D. Simmons , Gašper Tkačik , Vijay Balasubramanian , Philip C. Nelson

Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according to the identity of the neurons that generated them. Existing techniques perform this classification ignoring several properties of actual neurons…

Quantitative Methods · Quantitative Biology 2007-05-23 Christophe Pouzat

Spike sorting is a fundamental preprocessing step for many neuroscience studies which rely on the analysis of spike trains. In this paper, we present two unsupervised spike sorting algorithms based on discriminative subspace learning. The…

Computer Vision and Pattern Recognition · Computer Science 2014-08-25 Mohammad Reza Keshtkaran , Zhi Yang

Spike sorting is a crucial step in decoding multichannel extracellular neural signals, enabling the identification of individual neuronal activity. A key challenge in brain-machine interfaces (BMIs) is achieving real-time, low-power spike…

Neural and Evolutionary Computing · Computer Science 2025-07-01 Alexis Melot , Sean U. N. Wood , Yannick Coffinier , Pierre Yger , Fabien Alibart
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