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High resolution optical endoscopes are increasingly used in diagnosis of various medical conditions of internal organs, such as the gastrointestinal tracts, but they are too expensive for use in resource-poor settings. On the other hand,…

Optics · Physics 2016-03-08 Xiangqian Hong , Vivek K. Nagarajan , Dale H. Mugler , Bing Yu

Endoscopy is the most widely used imaging technique for the diagnosis of cancerous lesions in hollow organs. However, endoscopic images are often affected by illumination artefacts: image parts may be over- or underexposed according to the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Axel Garcia-Vega , Ricardo Espinosa , Luis Ramirez-Guzman , Thomas Bazin , Luis Falcon-Morales , Gilberto Ochoa-Ruiz , Dominique Lamarque , Christian Daul

Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, the state-of-the-art micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use…

Optics · Physics 2022-11-09 Noam Badt , Ori Katz

Endoscopic optical imaging using a single multimode fiber (MMF) has emerged as a promising approach for highly compact, minimally invasive, and high-resolution imaging. Unlike conventional fiber bundles, MMF-based endomicroscopes exploit…

Endoluminal surgery offers a minimally invasive option for early-stage gastrointestinal and urinary tract cancers but is limited by surgical tools and a steep learning curve. Robotic systems, particularly continuum robots, provide flexible…

Different modalities of medical images provide unique physiological and anatomical information for diseases. Multi-modal medical image fusion integrates useful information from different complementary medical images with different…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Yushen Xu , Xiaosong Li , Yuchun Wang , Xiaoqi Cheng , Huafeng Li , Haishu Tan

The science and clinical practice of medical physics has been integral to the advancement of radiology and radiation therapy for over a century. In parallel, advances in surgery - including intraoperative imaging, registration, and other…

Medical Physics · Physics 2025-09-04 Jeffrey H. Siewerdsen

Microscopy is an essential tool in scientific research, enabling the visualization of structures at micro- and nanoscale resolutions. However, the field of microscopy often encounters limitations in field-of-view (FOV), restricting the…

Image and Video Processing · Electrical Eng. & Systems 2025-03-17 Huanhuan Zhao , Ruben Millan-Solsona , Marti Checa , Spenser R. Brown , Jennifer L. Morrell-Falvey , Liam Collins , Arpan Biswas

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Clinical diffusion imaging requires short acquisition times and good image quality to permit its use in various medical applications. In turn, these demands require the development of a robust and efficient post-processing framework in…

Medical Physics · Physics 2015-02-18 Ivan I. Maximov , Farida Grinberg , Irene Neuner , N. Jon Shah

Image compression is one of the most fundamental techniques and commonly used applications in the image and video processing field. Earlier methods built a well-designed pipeline, and efforts were made to improve all modules of the pipeline…

Image and Video Processing · Electrical Eng. & Systems 2021-03-29 Yueyu Hu , Wenhan Yang , Zhan Ma , Jiaying Liu

Image sensors are the backbone of many imaging technologies of great importance to modern sciences, being particularly relevant in biomedicine. An ideal image sensor should be usable through all the electromagnetic spectrum (large…

Medical Physics · Physics 2022-03-16 Juan Aguirre

Following recent advancements in multimode fiber (MMF), miniaturization of imaging endoscopes has proven crucial for minimally invasive surgery in vivo. Recent progress enabled by super-resolution imaging methods with a data-driven deep…

Optics · Physics 2023-07-12 Chuncheng Zhang , Tingting Liu , Zhihua Xie , Yu Wang , Tong Liu , Qian Chen , Xiubao Sui

Poor access to eye care is a major global challenge that could be ameliorated by low-cost, portable, and easy-to-use diagnostic technologies. Diffuser-based imaging has the potential to enable inexpensive, compact optical systems that can…

Medical Physics · Physics 2020-06-23 Yunzhe Li , Gregory N. McKay , Nicholas J. Durr , Lei Tian

Image analysis using more than one modality (i.e. multi-modal) has been increasingly applied in the field of biomedical imaging. One of the challenges in performing the multimodal analysis is that there exist multiple schemes for fusing the…

Computer Vision and Pattern Recognition · Computer Science 2018-06-19 Zhe Guo , Xiang Li , Heng Huang , Ning Guo , Quanzheng Li

When multimode optical fibers are perturbed, the data that is transmitted through them is scrambled. This presents a major difficulty for many possible applications, such as multimode fiber-based telecommunication and endoscopy. To overcome…

Image and Video Processing · Electrical Eng. & Systems 2022-02-17 Shachar Resisi , Sebastien M. Popoff , Yaron Bromberg

Fluorescence microscopy is an important and extensively utilised tool for imaging biological systems. However, the image resolution that can be obtained has a limit as defined through the laws of diffraction. Demand for improved resolution…

Biological Physics · Physics 2007-08-27 James H. Rice

Automatic detection and segmentation of objects in 2D and 3D microscopy data is important for countless biomedical applications. In the natural image domain, spatial embedding-based instance segmentation methods are known to yield…

Image and Video Processing · Electrical Eng. & Systems 2021-04-30 Manan Lalit , Pavel Tomancak , Florian Jug

Current tomographic imaging systems need major improvements, especially when multi-dimensional, multi-scale, multi-temporal and multi-parametric phenomena are under investigation. Both preclinical and clinical imaging now depend on in vivo…

With the advent of neuroimaging and microsurgery, there is a rising need for capturing images through an optical fiber. We present an approach of imaging through a single fiber without mechanical scanning by implementing spatial-spectral…