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Immunology is the emerging research area which deals with the study of the immune system in any living organism. It is modelled through various computational and mathematical models to deal with the problem facing while to boost the immune…

Cell Behavior · Quantitative Biology 2019-06-21 Gajendra Pratap Singh , Madhuri Jha

This paper proposes EvoAgent - an evolvable large language model (LLM) agent framework that integrates structured skill learning with a hierarchical sub-agent delegation mechanism. EvoAgent models skills as multi-file structured capability…

Artificial Intelligence · Computer Science 2026-04-27 Aimin Zhang , Jiajing Guo , Fuwei Jia , Chen Lv , Boyu Wang , Fangzheng Li

We present a new approach to the simulation and analysis of immune system behavior. The simulations that can be done with our software package called SIMMUNE are based on immunological data that describe the behavior of immune system agents…

Multiagent Systems · Computer Science 2007-05-23 M. Meier-Schellersheim , G. Mack

Multi-agent reinforcement learning has shown promise on a variety of cooperative tasks as a consequence of recent developments in differentiable inter-agent communication. However, most architectures are limited to pools of homogeneous…

Multiagent Systems · Computer Science 2019-09-13 Bowen Jing , William Yin

Agent-based simulation is an indispensable paradigm for studying complex systems. These systems can comprise billions of agents, requiring the computing resources of multiple servers to simulate. Unfortunately, the state-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-30 Lukas Breitwieser , Ahmad Hesam , Abdullah Giray Yağlıkçı , Mohammad Sadrosadati , Fons Rademakers , Onur Mutlu

Modeling agent behavior is central to understanding the emergence of complex phenomena in multiagent systems. Prior work in agent modeling has largely been task-specific and driven by hand-engineering domain-specific prior knowledge. We…

Multiagent Systems · Computer Science 2018-08-02 Aditya Grover , Maruan Al-Shedivat , Jayesh K. Gupta , Yura Burda , Harrison Edwards

Cellular Agent-Based Models are commonly employed to describe a variety biological systems. Over the course of the past years, many modeling tools have emerged which solve particular research questions. In this short opinion piece, we argue…

Cell Behavior · Quantitative Biology 2025-11-18 Jonas Pleyer

Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellular states and behaviors. This work provides a comprehensive…

Computation and Language · Computer Science 2025-10-10 Krinos Li , Xianglu Xiao , Shenglong Deng , Lucas He , Zijun Zhong , Yuanjie Zou , Zhonghao Zhan , Zheng Hui , Weiye Bao , Guang Yang

The concentration gradient of the Bicoid morphogen, which is established during the early stages of a Drosophila melanogaster embryonic development, determines the differential spatial patterns of gene expression and subsequent cell fate…

Multiagent Systems · Computer Science 2014-12-18 Mariam Kiran , Wei Liu

Agent-based modeling and simulation has evolved as a powerful tool for modeling complex systems, offering insights into emergent behaviors and interactions among diverse agents. Integrating large language models into agent-based modeling…

Artificial Intelligence · Computer Science 2023-12-20 Chen Gao , Xiaochong Lan , Nian Li , Yuan Yuan , Jingtao Ding , Zhilun Zhou , Fengli Xu , Yong Li

The use of oncolytic viruses as cancer treatment has received considerable attention in recent years, however the spatial dynamics of this viral infection is still poorly understood. We present here a stochastic agent-based model describing…

Populations and Evolution · Quantitative Biology 2023-09-06 David Morselli , Marcello Edoardo Delitala , Federico Frascoli

The design and development of a complex system requires an adequate methodology and efficient instrumental support in order to early detect and correct anomalies in the functional and non-functional properties of the tested protocols. Among…

Networking and Internet Architecture · Computer Science 2012-04-03 Emmanuel Lochin , Tanguy Perennou , Laurent Dairaine

The visual analytics community has long aimed to understand users better and assist them in their analytic endeavors. As a result, numerous conceptual models of visual analytics aim to formalize common workflows, techniques, and goals…

Human-Computer Interaction · Computer Science 2023-04-20 Shayan Monadjemi , Mengtian Guo , David Gotz , Roman Garnett , Alvitta Ottley

The premise of this working paper is based around agent-based simulation models and how to go about creating them from given incomplete information. Agent-based simulations are stochastic simulations that revolve around groups of agents…

Multiagent Systems · Computer Science 2019-02-06 Daniel Stroud , Christian Wagner , Peer-Olaf Siebers

Trilogy is a collaborative project whose key aim is the development of an integrated virtual laboratory to support research training within each institution and collaborative projects between the partners. In this paper, the architecture…

Digital Libraries · Computer Science 2007-05-23 Franck Chevalier , David Harle , Geoffrey Smith

We introduce a Python package for modeling and studying the spread of infectious diseases using an agent-based SEIR style epidemiological model with a focus on university campuses. This document explains the epidemiological model used in…

Populations and Evolution · Quantitative Biology 2020-11-13 Matthew Zalesak , Samitha Samaranayake

Mobile agents research is clearly aiming towards imposing agent based development as the next generation of tools for writing software. This paper comes with its own contribution to this global goal by introducing a novel unifying framework…

Multiagent Systems · Computer Science 2007-05-23 Tudor Marian , Bogdan Dumitriu , Mihaela Dinsoreanu , Ioan Salomie

In this paper, we propose to develop service model architecture by merging multi-agentsystems and semantic web technology. The proposed architecture works in two stages namely, Query Identification and Solution Development. A person…

Multiagent Systems · Computer Science 2012-09-03 Muneendra Ojha

Agent-based models (ABMs) are gaining increasing traction in several domains, due to their ability to represent complex systems that are not easily expressible with classical mathematical models. This expressivity and richness come at a…

Multiagent Systems · Computer Science 2025-09-16 Marco Pangallo , Daniele Giachini , Andrea Vandin

The rise of powerful large language models (LLMs) has spurred a new trend in building LLM-based autonomous agents for solving complex tasks, especially multi-agent systems. Despite the remarkable progress, we notice that existing works are…

Artificial Intelligence · Computer Science 2025-03-11 Siyu Yuan , Kaitao Song , Jiangjie Chen , Xu Tan , Dongsheng Li , Deqing Yang
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