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Cell-based, mathematical modeling of collective cell behavior has become a prominent tool in developmental biology. Cell-based models represent individual cells as single particles or as sets of interconnected particles, and predict the…

Cell Behavior · Quantitative Biology 2019-03-12 Henri B. Wolff , Lance A. Davidson , Roeland M. H. Merks

Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory…

Molecular Networks · Quantitative Biology 2017-09-21 John A. P. Sekar , James R. Faeder

Many advances in research regarding immuno-interactions with cancer were developed with the help of ordinary differential equation (ODE) models. These models, however, are not effectively capable of representing problems involving…

Computational Engineering, Finance, and Science · Computer Science 2013-06-03 Grazziela P. Figueredo , Peer-Olaf Siebers , Uwe Aickelin

We present LUNES, an agent-based Large Unstructured NEtwork Simulator, which allows to simulate complex networks composed of a high number of nodes. LUNES is modular, since it splits the three phases of network topology creation, protocol…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-03-19 Gabriele D'Angelo , Stefano Ferretti

Agent-based modeling is indispensable for studying complex systems across many domains. However, existing simulation platforms exhibit two major issues: performance and modularity. Low performance prevents simulations with a large number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-17 Lukas Johannes Breitwieser

Agent-based modeling and simulation is a useful method to study biological phenomena in a wide range of fields, from molecular biology to ecology. Since there is currently no agreed-upon standard way to specify such models it is not always…

Quantitative Methods · Quantitative Biology 2010-10-14 Franziska Hinkelmann , David Murrugarra , Abdul Salam Jarrah , Reinhard Laubenbacher

We construct a model of social behaviour through the dynamics of interacting agents. The agents undergo game-theoretic interactions where each agent can decide to lend support to particular other agents or otherwise, and agents are rewarded…

Physics and Society · Physics 2007-05-23 Wan Ahmad Tajuddin Wan Abdullah , A. K. M. Azhar

Most of the grand challenges of humanity today involve complex agent-based systems, such as epidemiology, economics or ecology. However, remains as a pending task the challenge of identifying the general principles underlying their…

General Finance · Quantitative Finance 2020-10-19 Martin Jaraiz

\EcoLab{} is an agent based modeling system for C++ programmers, strongly influenced by the design of Swarm. This paper is just a brief outline of \EcoLab's features, more details can be found in other published articles, documentation and…

Multiagent Systems · Computer Science 2007-05-23 Russell K. Standish , Richard Leow

In this study, we present the Physical-Bio Translator, an agent-based simulation model designed to simulate cellular responses following irradiation. This simulation framework is based on a novel cell-state transition model that accurately…

Medical Physics · Physics 2025-11-21 Ruirui Liu , Marciek H. Swat , James A. Glazier , Yu Lei , Sumin Zhou , Kathryn A. Higley

This paper presents a system for procedurally generating agent-based narratives using large language models (LLMs). Users could drag and drop multiple agents and objects into a scene, with each entity automatically assigned semantic…

Graphics · Computer Science 2025-12-24 Vinayak Regmi , Christos Mousas

The fundamental understanding of how cells physically interact with each other and their environment is key to understanding their organisation in living tissues. Over the past decades several computational methods have been developed to…

Quantitative Methods · Quantitative Biology 2026-01-22 Paul Van Liedekerke , Jiří Pešek , Kevin Alessandri , Dirk Drasdo

The recent rapid development of large language models (LLMs) has sparked a new wave of technological revolution in medical artificial intelligence (AI). While LLMs are designed to understand and generate text like a human, autonomous agents…

Artificial Intelligence · Computer Science 2025-01-20 Junkai Li , Yunghwei Lai , Weitao Li , Jingyi Ren , Meng Zhang , Xinhui Kang , Siyu Wang , Peng Li , Ya-Qin Zhang , Weizhi Ma , Yang Liu

We propose an agent architecture that automates parts of the common reinforcement learning experiment workflow, to enable automated mastery of control domains for embodied agents. To do so, it leverages a VLM to perform some of the…

Artificial Intelligence · Computer Science 2024-09-06 Jingwei Zhang , Thomas Lampe , Abbas Abdolmaleki , Jost Tobias Springenberg , Martin Riedmiller

Building generalist agents that can handle diverse tasks and evolve themselves across different environments is a long-term goal in the AI community. Large language models (LLMs) are considered a promising foundation to build such agents…

Memory emerges as the core module in the Large Language Model (LLM)-based agents for long-horizon complex tasks (e.g., multi-turn dialogue, game playing, scientific discovery), where memory can enable knowledge accumulation, iterative…

Imitation learning, which learns agent policy by mimicking expert demonstration, has shown promising results in many applications such as medical treatment regimes and self-driving vehicles. However, it remains a difficult task to interpret…

Machine Learning · Computer Science 2024-01-31 Tianxiang Zhao , Wenchao Yu , Suhang Wang , Lu Wang , Xiang Zhang , Yuncong Chen , Yanchi Liu , Wei Cheng , Haifeng Chen

In the paper, the model of the society represented by a social network and the model of a multi-agent system built on the basis of this, is presented. The particular aim of the system is to predict the evolution of a society and an analysis…

Social and Information Networks · Computer Science 2016-10-05 Jarosław Koźlak , Anna Zygmunt

Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without…

The era of intelligent agents is upon us, driven by revolutionary advancements in large language models. Large Language Model (LLM) agents, with goal-driven behaviors and dynamic adaptation capabilities, potentially represent a critical…