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Spiculations/lobulations, sharp/curved spikes on the surface of lung nodules, are good predictors of lung cancer malignancy and hence, are routinely assessed and reported by radiologists as part of the standardized Lung-RADS clinical…

Image and Video Processing · Electrical Eng. & Systems 2022-07-01 Wookjin Choi , Navdeep Dahiya , Saad Nadeem

Lung cancer ranks as one of the leading causes of cancer diagnosis and is the foremost cause of cancer-related mortality worldwide. The early detection of lung nodules plays a pivotal role in improving outcomes for patients, as it enables…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Jiasen Zhang , Mingrui Yang , Weihong Guo , Brian A. Xavier , Michael Bolen , Xiaojuan Li

Pathologies systematically induce morphological changes, thus providing a major but yet insufficiently quantified source of observables for diagnosis. The study develops a predictive model of the pathological states based on morphological…

Computed tomography imaging is a standard modality for detecting and assessing lung cancer. In order to evaluate the malignancy of lung nodules, clinical practice often involves expert qualitative ratings on several criteria describing a…

Computer Vision and Pattern Recognition · Computer Science 2016-09-22 Mario Buty , Ziyue Xu , Mingchen Gao , Ulas Bagci , Aaron Wu , Daniel J. Mollura

While deep learning methods are increasingly being applied to tasks such as computer-aided diagnosis, these models are difficult to interpret, do not incorporate prior domain knowledge, and are often considered as a "black-box." The lack of…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Shiwen Shen , Simon X. Han , Denise R. Aberle , Alex A. T. Bui , Willliam Hsu

Machine learning models have utilized semantic features, deep features, or both to assess lung nodule malignancy. However, their reliance on manual annotation during inference, limited interpretability, and sensitivity to imaging variations…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Luoting Zhuang , Seyed Mohammad Hossein Tabatabaei , Ramin Salehi-Rad , Linh M. Tran , Denise R. Aberle , Ashley E. Prosper , William Hsu

The early identification of malignant pulmonary nodules is critical for better lung cancer prognosis and less invasive chemo or radio therapies. Nodule malignancy assessment done by radiologists is extremely useful for planning a preventive…

Image and Video Processing · Electrical Eng. & Systems 2019-12-19 Ilaria Bonavita , Xavier Rafael-Palou , Mario Ceresa , Gemma Piella , Vicent Ribas , Miguel A. González Ballester

Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve…

Computer Vision and Pattern Recognition · Computer Science 2018-02-07 Jason Causey , Junyu Zhang , Shiqian Ma , Bo Jiang , Jake Qualls , David G. Politte , Fred Prior , Shuzhong Zhang , Xiuzhen Huang

Purpose: This study investigated how nodule segmentation and surrounding peritumoral regions influence radionics-based lung cancer classification. Methods: Using 3D CT scans with bounding box annotated nodules, we generated 3D segmentations…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Fakrul Islam Tushar

Consistency and duplicability in Computed Tomography (CT) output is essential to quantitative imaging for lung cancer detection and monitoring. This study of CT-detected lung nodules investigated the reproducibility of volume-, density-,…

Early detection of lung cancer has been proven to decrease mortality significantly. A recent development in computed tomography (CT), spectral CT, can potentially improve diagnostic accuracy, as it yields more information per scan than…

Computer Vision and Pattern Recognition · Computer Science 2020-07-01 Linde S. Hesse , Pim A. de Jong , Josien P. W. Pluim , Veronika Cheplygina

Lung cancer is the leading cause of cancer related mortality by a significant margin. While new technologies, such as image segmentation, have been paramount to improved detection and earlier diagnoses, there are still significant…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Marguerite B. Basta , Sarfaraz Hussein , Hsiang Hsu , Flavio P. Calmon

Lung cancer classification in screening computed tomography (CT) scans is one of the most crucial tasks for early detection of this disease. Many lives can be saved if we are able to accurately classify malignant/cancerous lung nodules.…

Image and Video Processing · Electrical Eng. & Systems 2021-09-20 Mundher Al-Shabi , Kelvin Shak , Maxine Tan

Early detection of lung cancer is crucial for effective treatment and relies on accurate volumetric assessment of pulmonary nodules in CT scans. Traditional methods, such as consolidation-to-tumor ratio (CTR) and spherical approximation,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-29 Yihan Zhou , Haocheng Huang , Yue Yu , Jianhui Shang

Statistical models for predicting lung cancer have the potential to facilitate earlier diagnosis of malignancy and avoid invasive workup of benign disease. Many models have been published, but comparative studies of their utility in…

Lung cancer has the highest mortality rate of deadly cancers in the world. Early detection is essential to treatment of lung cancer. However, detection and accurate diagnosis of pulmonary nodules depend heavily on the experiences of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Chenglong Wang , Yun Liu , Fen Wang , Chengxiu Zhang , Yida Wang , Mei Yuan , Guang Yang

Early detection of malignant lung nodules remains constrained by size and growth based screening criteria, often delaying diagnosis. We present an integrated AI system that jointly performs nodule detection and malignancy assessment…

Lung cancer is a leading cause of death worldwide and early screening is critical for improving survival outcomes. In clinical practice, the contextual structure of nodules and the accumulated experience of radiologists are the two core…

Image and Video Processing · Electrical Eng. & Systems 2023-07-21 Jianpeng Zhang , Xianghua Ye , Jianfeng Zhang , Yuxing Tang , Minfeng Xu , Jianfei Guo , Xin Chen , Zaiyi Liu , Jingren Zhou , Le Lu , Ling Zhang

Purpose: Lung nodules have very diverse shapes and sizes, which makes classifying them as benign/malignant a challenging problem. In this paper, we propose a novel method to predict the malignancy of nodules that have the capability to…

Computer Vision and Pattern Recognition · Computer Science 2019-04-24 Mundher Al-Shabi , Boon Leong Lan , Wai Yee Chan , Kwan-Hoong Ng , Maxine Tan

Lung cancer remains the leading cause of cancer-related mortality worldwide, with survival strongly dependent on early detection. Standard-dose computed tomography (CT) screening using the Lung Imaging Reporting and Data System (Lung-RADS)…

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