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Free-energy landscapes for short peptides -- specifically for variants of the pH Low Insertion Peptide (pHLIP) -- in the heterogeneous environment of a lipid bilayer or cell membrane are constructed, taking into account a set of dominant…

Soft Condensed Matter · Physics 2022-07-22 Ganga P. Sharma , Aaron C. Meyer , Suhail Habeeb , Michael Karbach , Gerhard Müller

Within the frame of an effective, coarse-grained hydrophobic-polar protein model, we employ multicanonical Monte Carlo simulations to investigate free-energy landscapes and folding channels of exemplified heteropolymer sequences, which are…

Soft Condensed Matter · Physics 2009-11-13 Stefan Schnabel , Michael Bachmann , Wolfhard Janke

By applying the renormalization group method to two-coupled chains in the Tomonaga model, the role of interchain hopping has been studied in the entire energy region. The energy for a crossover from the perturbational regime to the relevant…

Strongly Correlated Electrons · Physics 2009-10-30 Masahisa Tsuchiizu , Hideo Yoshioka , Yoshikazu Suzumura

An all-atom model of proteins is used to show that the same sequence of amino acids can have many alternative structures, that are very distant from, and that can be as stable as, the corresponding native structure. Such alternative…

Biological Physics · Physics 2008-02-11 Leonor Cruzeiro

Motivated by the recently observed phenomenon of topology trivialization of potential energy landscapes (PELs) for several statistical mechanics models, we perform a numerical study of the finite size $2$-spin spherical model using both…

Statistical Mechanics · Physics 2015-03-05 Dhagash Mehta , Jonathan D. Hauenstein , Matthew Niemerg , Nicholas J. Simm , Daniel A. Stariolo

In this paper, we investigate the energy landscape of the two-component spin systems, known as the Curie-Weiss-Potts model, which is a generalization of the Curie-Weiss model consisting of $q\ge3$ spins. In the energy landscape of a…

Probability · Mathematics 2022-06-22 Daecheol Kim

We present a method to explore the free energy landscapes of chemical reactions with post-transition-state bifurcations using an enhanced sampling method based on well-tempered metadynamics. Obviating the need for computationally expensive…

Chemical Physics · Physics 2023-04-18 Juno Nam , YounJoon Jung

The energy landscapes of proteins have evolved to be different from most random heteropolymers. Many studies have concluded that evolutionary selection for rapid and reliable folding to a given structure that is stable at biological…

Disordered Systems and Neural Networks · Physics 2009-11-10 Steven S. Plotkin , Peter G. Wolynes

In the presence of a finite interlayer displacement field bilayer graphene has an energy gap that is dependent on stacking and largest for the stable AB and BA stacking arrangements. When the relative orientations between layers are twisted…

Mesoscale and Nanoscale Physics · Physics 2018-07-11 Dmitry K. Efimkin , Allan H. MacDonald

The bending energy of any freely deformable closed surface is quadratic in its curvature. In the absence of constraints, it will be minimized when the surface adopts the form of a round sphere. If the surface is confined within a…

Mathematical Physics · Physics 2013-03-19 Jemal Guven , José Antonio Santiago , Pablo Vázquez-Montejo

Ground-state and magnetocaloric properties of a double-tetrahedral chain, in which nodal lattice sites occupied by the localized Ising spins regularly alternate with triangular clusters half filled with mobile electrons, are exactly…

Statistical Mechanics · Physics 2016-10-12 Lucia Galisova , Dorota Jakubczyk

The scaling of fluctuations in the distribution of ground-state energies or costs with the system size N for Ising spin glasses is considered using an extensive set of simulations with the Extremal Optimization heuristic across a range of…

Disordered Systems and Neural Networks · Physics 2022-05-20 Stefan Boettcher

The Spin-1/2 Heisenberg Model (HM) is investigated using a block-spin renormalization approach on Kagome and triangular lattices. In both cases, after coarse graining the triangles on original lattice and truncation of the Hilbert space to…

Condensed Matter · Physics 2007-05-23 V. Subrahmanyam

We study the global influence of curvature on the free energy landscape of two-dimensional binary mixtures confined on closed surfaces. Starting from a generic effective free energy, constructed on the basis of symmetry considerations and…

Soft Condensed Matter · Physics 2019-09-11 Piermarco Fonda , Melissa Rinaldin , Daniela J. Kraft , Luca Giomi

Free energy landscapes encode the kinetics, intermediates, and transition states that govern molecular processes and are thus a key target of single biomolecule research. Typical approaches to deriving optimal, error-minimizing,…

Biological Physics · Physics 2025-11-25 Oliver Cheng , Zosia Adamska , Michael P. Brenner , Megan C. Engel

A relation between a class of stationary points of the energy landscape of continuous spin models on a lattice and the configurations of a Ising model defined on the same lattice suggests an approximate expression for the microcanonical…

Statistical Mechanics · Physics 2011-03-22 Lapo Casetti , Cesare Nardini , Rachele Nerattini

Properties of the free energy landscape in phase space of a dense hard sphere system characterized by a discretized free energy functional of the Ramakrishnan-Yussouff form are investigated numerically. A considerable number of glassy local…

Disordered Systems and Neural Networks · Physics 2009-10-31 Chandan Dasgupta , Oriol T. Valls

Free-energy landscape theory is often used to describe complex molecular systems. Here, a microscopic description of water structure and dynamics based on configuration-space-networks and molecular dynamics simulations of the TIP4P/2005…

Statistical Mechanics · Physics 2015-06-05 Diego Prada-Gracia , Roman Shevchuk , Peter Hamm , Francesco Rao

We investigate spin-flip scattering processes of electrons when they pass a chiral interface, which is the boundary between right- and left-handed one-dimensional chain. We construct a minimal $p$-orbital model consisting of the right- and…

Mesoscale and Nanoscale Physics · Physics 2025-05-12 Keita Matsubara , Kazumasa Hattori

We theoretically study the electronic structure of small-angle twisted bilayer graphene with a large potential asymmetry between the top and bottom layers. We show that the emergent helical states known to appear on the triangular AB-BA…

Mesoscale and Nanoscale Physics · Physics 2020-03-18 Bonnie Tsim , Nguyen N. T. Nam , Mikito Koshino