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Many biological systems, such as metabolic pathways, exhibit bistability behavior: these biological systems exhibit two distinct stable states with switching between the two stable states controlled by certain conditions. Since…

Quantitative Methods · Quantitative Biology 2013-07-04 Yi Ming Zou

When analyzing complex networks a key target is to uncover their modular structure, which means searching for a family of modules, namely node subsets spanning each a subnetwork more densely connected than the average. This work proposes a…

Discrete Mathematics · Computer Science 2018-09-10 Giovanni Rossi

Single-cell gene expression measurements offer opportunities in deriving mechanistic understanding of complex diseases, including cancer. However, due to the complex regulatory machinery of the cell, gene regulatory network (GRN) model…

Genomics · Quantitative Biology 2019-02-11 Ehsan Hajiramezanali , Mahdi Imani , Ulisses Braga-Neto , Xiaoning Qian , Edward R Dougherty

Boolean networks constitute relevant mathematical models to study the behaviours of genetic and signalling networks. These networks define regulatory influences between molecular nodes, each being associated to a Boolean variable and a…

Discrete Mathematics · Computer Science 2025-06-24 José E. R. Cury , Patrícia Tenera Roxo , Vasco Manquinho , Claudine Chaouiya , Pedro T. Monteiro

A Multi-hop Control Network (MCN) consists of a plant where the communication between sensor, actuator and computational unit is supported by a wireless multi-hop communication network, and data flow is performed using scheduling and…

Optimization and Control · Mathematics 2011-04-08 Maria D. Di Benedetto , Alessandro D'Innocenzo , Emmanuele Serra

The determination and classification of fixed points of large Boolean networks is addressed in terms of constraint satisfaction problem. We develop a general simplification scheme that, removing all those variables and functions belonging…

Disordered Systems and Neural Networks · Physics 2009-11-10 L. Correale , M. Leone , A. Pagnani , M. Weigt , R. Zecchina

We have considered a Boolean control network where the state evolution equations depend on past states, controls and first derivatives of a function with respect to controls. Total approach has been the efficient use of matrix semi tensor…

Optimization and Control · Mathematics 2020-08-20 Souma Mazumdar

In this paper, we propose the Broadcasting Convolutional Network (BCN) that extracts key object features from the global field of an entire input image and recognizes their relationship with local features. BCN is a simple network module…

Computer Vision and Pattern Recognition · Computer Science 2018-08-27 Simyung Chang , John Yang , Seonguk Park , Nojun Kwak

Control of complex processes is a major goal of network analyses. Most approaches to control nonlinearly coupled systems require the network topology and/or network dynamics. Unfortunately, neither the full set of participating nodes nor…

Molecular Networks · Quantitative Biology 2014-12-23 Jason Shulman , Frank Malatino , Alexander Mo , Killian Ryan , Gemunu H. Gunaratne

Many real-world systems are characterized by stochastic dynamical rules where a complex network of interactions among individual elements probabilistically determines their state. Even with full knowledge of the network structure and of the…

Physics and Society · Physics 2018-05-15 Filippo Radicchi , Claudio Castellano

We consider the compilation of a binary neural network's decision function into tractable representations such as Ordered Binary Decision Diagrams (OBDDs) and Sentential Decision Diagrams (SDDs). Obtaining this function as an OBDD/SDD…

Machine Learning · Computer Science 2020-07-06 Weijia Shi , Andy Shih , Adnan Darwiche , Arthur Choi

For many real-life Bayesian networks, common knowledge dictates that the output established for the main variable of interest increases with higher values for the observable variables. We define two concepts of monotonicity to capture this…

Artificial Intelligence · Computer Science 2012-07-19 Linda C. van der Gaag , Hans L. Bodlaender , Ad Feelders

In this paper, we investigate the controllability of a linear time-invariant network following a Laplacian dynamics defined on a threshold graph. In this direction, an algorithm for deriving the modal matrix associated with the Laplacian…

Optimization and Control · Mathematics 2019-04-23 Shima Sadat Mousavi , Mohammad Haeri , Mehran Mesbahi

This is the second in a series of articles aimed at exploring the relationship between the complexity classes of P and NP. The research in this article aims to find conditions of an algorithmic nature that are necessary and sufficient to…

Computational Complexity · Computer Science 2023-11-07 Stepan G. Margaryan

Output controllability and functional observability are properties that enable, respectively, the control and estimation of part of the state vector. These notions are of utmost importance in applications to high-dimensional systems, such…

Optimization and Control · Mathematics 2025-08-04 Arthur N. Montanari , Chao Duan , Adilson E. Motter

We present a provable, sampling-based approach for generating compact Convolutional Neural Networks (CNNs) by identifying and removing redundant filters from an over-parameterized network. Our algorithm uses a small batch of input data…

Machine Learning · Computer Science 2020-03-24 Lucas Liebenwein , Cenk Baykal , Harry Lang , Dan Feldman , Daniela Rus

This paper addresses problems on the robust structural design of complex networks. More precisely, we address the problem of deploying the minimum number of dedicated sensors, i.e., those measuring a single state variable, that ensure the…

Optimization and Control · Mathematics 2016-06-13 Xiaofei Liu , Sergio Pequito , Soummya Kar , Bruno Sinopoli , A. Pedro Aguiar

Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical rules. They were introduced as dynamic models into biology, in particular as logical models of intracellular regulatory…

Dynamical Systems · Mathematics 2025-04-16 J. García Galofre , M. Pérez Millán , A. Galarza Rial , R. Laubenbacher , A. Dickenstein

Inferring network topology from smooth signals is a significant problem in data science and engineering. A common challenge in real-world scenarios is the availability of only partially observed nodes. While some studies have considered…

Machine Learning · Computer Science 2025-07-08 Chuansen Peng , Hanning Tang , Zhiguo Wang , Xiaojing Shen

We define a measure for the complexity of Boolean functions related to their implementation in neural networks, and in particular close related to the generalization ability that could be obtained through the learning process. The measure…

Disordered Systems and Neural Networks · Physics 2007-05-23 Leonardo Franco