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Blood flow in sickle cell disease (SCD) can substantially differ from normal blood flow due to significant alterations in the physical properties of the red blood cells (RBCs). Chronic complications, such as inflammation of the endothelial…

Biological Physics · Physics 2020-05-13 Xiao Zhang , Christina Caruso , Wilbur A. Lam , Michael D. Graham

Evaporation of blood droplets and diluted blood samples is a topic of intensive research, as it is seen as a possible low-cost tool for diagnosis. So far, samples with volume fraction down to a few percents of Red Blood Cells (RBCs) have…

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

Efficient sorting of target cells is crucial for advancing cellular research in biology and medical diagnostics. Inertial microfluidics, an emerging technology, offers a promising approach for label-free particle sorting with high…

Fluid Dynamics · Physics 2023-08-04 Sayan Karmakar , Md Safwan Mondal , Anish Pal , Sourav Sarkar

Reservoir computing (RC) is known as a powerful machine learning approach for learning complex dynamics from limited data. Here, we use RC to predict highly stochastic dynamics of cell shapes. We find that RC is able to predict the steady…

Biological Physics · Physics 2024-09-17 Hoony Kang , Keshav Srinivasan , Wolfgang Losert

Constrictions in blood vessels and microfluidic devices can dramatically change the spatial distribution of passing cells or particles and are commonly used in biomedical cell sorting applications. However, the three-dimensional nature of…

Fluid Dynamics · Physics 2019-12-03 Asena Abay , Steffen M. Recktenwald , Thomas John , Lars Kaestner , Christian Wagner

We present a deformation-dependent propulsion phenomenon for soft particles such as cells in microchannels. It is based on a broken time reversal symmetry generated by a fast forward and slow backward motion of a fluid which does not…

Soft Condensed Matter · Physics 2022-02-22 Winfried Schmidt , Andre Förtsch , Matthias Laumann , Walter Zimmermann

Thrombosis is a common complication following the surgical implantation of blood contacting devices, and is strongly influenced by the phenomenon of near-wall enrichment of platelets. This paper describes a multi-constituent continuum…

Fluid Dynamics · Physics 2017-05-09 Wei-Tao Wu , Nadine Aubry , James F. Antaki , Mehrdad Massoudi

We analyse mathematical models in order to understand how microstructural features of vascular networks may affect blood-flow dynamics, and to identify particular characteristics that promote the onset of self-sustained oscillations. By…

Quantitative Methods · Quantitative Biology 2022-06-23 Yaron Ben-Ami , George W. Atkinson , Joe M. Pitt-Francis , Philip K. Maini , Helen M. Byrne

Characterizing the morpho-mechanical properties of red blood cells (RBCs) is crucial for understanding microvascular transport mechanisms and cellular pathophysiological processes, yet current computational models are constrained by…

Biological Physics · Physics 2025-08-12 Shuo Wang , Lei Ma , Ling Guo , Xuejin Li , Tao Zhou

We present a dual-stage neural network architecture for analyzing fine shape details from microscopy recordings in 3D. The system, tested on red blood cells, uses training data from both healthy donors and patients with a congenital blood…

Quantitative Methods · Quantitative Biology 2020-05-29 G. Simionato , K. Hinkelmann , R. Chachanidze , P. Bianchi , E. Fermo , R. van Wijk , M. Leonetti , C. Wagner , L. Kaestner , S. Quint

The dynamics of red blood cells (RBCs) in oscillatory shear flow was studied using differential equations of three variables: a shape parameter, the inclination angle $\theta$, and phase angle $\phi$ of the membrane rotation. In steady…

Soft Condensed Matter · Physics 2010-06-24 Hiroshi Noguchi

Thrombosis in rotary blood pumps arises from complex flow conditions that remain difficult to translate into reliable and interpretable risk predictions using existing computational models. This limitation reflects an incomplete…

Machine Learning · Computer Science 2025-12-19 Christopher Blum , Michael Neidlin

This paper presents a comprehensive methodology and comparative performance analysis for the automated classification and object detection of peripheral blood cells (PBCs) in microscopic images. Addressing the critical challenge of data…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Siddharth Sahay

We focus on the problem of unsupervised cell outlier detection and repair in mixed-type tabular data. Traditional methods are concerned only with detecting which rows in the dataset are outliers. However, identifying which cells are…

Machine Learning · Computer Science 2020-03-05 Simão Eduardo , Alfredo Nazábal , Christopher K. I. Williams , Charles Sutton

Identifying and counting blood components such as red blood cells, various types of white blood cells, and platelets is a critical task for healthcare practitioners. Deep learning approaches, particularly convolutional neural networks…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 H. Martin Gillis , Yogeshwar Shendye , Paul Hollensen , Alan Fine , Thomas Trappenberg

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…

Fluid Dynamics · Physics 2017-02-01 Christian Bächer , Lukas Schrack , Stephan Gekle

Various technologies, including computer vision models, are employed for the automatic monitoring of manual assembly processes in production. These models detect and classify events such as the presence of components in an assembly area or…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Anton Sergeev , Victor Minchenkov , Aleksei Soldatov , Vasiliy Kakurin , Yaroslav Mazikov

The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may…

Cell Behavior · Quantitative Biology 2015-06-03 Maria Zeitz , Pierre Sens

Capsule Networks (CapsNets) is a machine learning architecture proposed to overcome some of the shortcomings of convolutional neural networks (CNNs). However, CapsNets have mainly outperformed CNNs in datasets where images are small and/or…

Computer Vision and Pattern Recognition · Computer Science 2021-09-07 Juan P. Vigueras-Guillén , Arijit Patra , Ola Engkvist , Frank Seeliger