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The multi-cellular hydrodynamic interactions play a critical role in the phenomenology of blood flow in the microcirculation. A fast algorithm has been developed to simulate large numbers of cells modeled as elastic thin membranes. For red…

Fluid Dynamics · Physics 2008-10-14 Amir H. G. Isfahani , Hong Zhao , Jonathan B. Freund

Shape graphs are complex geometrical structures commonly found in biological and anatomical systems. A shape graph is a collection of nodes, some connected by curvilinear edges with arbitrary shapes. Their high complexity stems from the…

Computation · Statistics 2024-09-17 Benjamin Beaudett , Anuj Srivastava

Outlying observations can be challenging to handle and adversely affect subsequent analyses, especially in data with increasing dimensional complexity. Although outliers are not always undesired anomalies in the data and may possess…

Methodology · Statistics 2025-09-18 Anthony-Alexander Christidis , Gabriela Cohen-Freue

We present a numerical analysis of the lateral movement and equilibrium radial positions of red blood cells (RBCs) with major diameter of 8 $\mu$m under a Newtonian fluid in a circular channel with 50-$\mu$m diameter. Each RBC, modelled as…

Morphologies of red blood cells are normally interpreted by a pathologist. It is time-consuming and laborious. Furthermore, a misclassified red blood cell morphology will lead to false disease diagnosis and improper treatment. Thus, a…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Kitsuchart Pasupa , Supawit Vatathanavaro , Suchat Tungjitnob

The fluid dynamics video that is presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several…

Fluid Dynamics · Physics 2009-10-20 Jonathan R. Clausen , Daniel A. Reasor , Cyrus K. Aidun

The flow behavior of blood in microvessels is directly associated with tissue perfusion and oxygen delivery. Current efforts on modeling blood flow have primarily focused on the flow properties of blood with red blood cells (RBCs) having a…

Soft Condensed Matter · Physics 2024-06-03 Wei Chien , Gerhard Gompper , Dmitry A. Fedosov

Understanding sickle cell dynamics requires accurate identification of morphological transitions under diverse biophysical conditions, particularly in densely packed and overlapping cell populations. Here, we present an automated deep…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Nikhil Kadivar , Guansheng Li , Jianlu Zheng , Ming Dao , George Em Karniadakis , Mengjia Xu

We investigate the physics of an optically-driven micromotor of biological origin. A single, live red blood cell, when placed in an optical trap folds into a rod-like shape. If the trapping laser beam is circularly polarized, the folded RBC…

Biological Physics · Physics 2009-11-11 A. Ghosh , Supurna Sinha , J. A. Dharmadhikari , S. Roy , A. K. Dharmadhikari , J. Samuel , S. Sharma , D. Mathur

Identifying and characterizing the patient's blood samples is indispensable in diagnostics of malignance suspicious. A painstaking and sometimes subjective task is used in laboratories to manually classify white blood cells. Neural…

Image and Video Processing · Electrical Eng. & Systems 2020-10-23 Daouda Diouf , Djibril Seck , Mountaga Diop , Abdoulye Ba

High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable…

Computational Engineering, Finance, and Science · Computer Science 2019-09-26 Libin Lu , Matthew J. Morse , Abtin Rahimian , Georg Stadler , Denis Zorin

Bifurcations and branches in the microcirculation dramatically affect blood flow as they determine the spatiotemporal organization of red blood cells (RBCs). Such changes in vessel geometries can further influence the formation of a…

Cerebral aneurysms and arteriovenous malformations are life-threatening hemodynamic pathologies of the brain. While surgical intervention is often essential to prevent fatal outcomes, it carries significant risks both during the procedure…

Machine Learning · Computer Science 2026-03-17 Irem Topal , Alexander Cherevko , Yuri Bugay , Maxim Shishlenin , Jean Barbier , Deniz Eroglu , Édgar Roldán , Roman Belousov

Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear-thinning is intimately related to the dynamics and mutual interactions of red blood cells (RBCs), the major…

We present experiments on RBCs that flow through microcapillaries under physiological conditions. We show that the RBC clusters form as a subtle imbrication between hydrodynamics interaction and adhesion forces because of plasma proteins.…

The stress-free state (SFS) of red blood cells (RBCs) is a fundamental reference configuration for the calibration of computational models, yet it remains unknown. Current experimental methods cannot measure the SFS of cells without…

Computational Engineering, Finance, and Science · Computer Science 2023-04-04 Lucas Amoudruz , Athena Economides , Georgios Arampatzis , Petros Koumoutsakos

We explore the rheology and flow-induced morphological changes of cholesteric liquid crystal patterns subject to Poiseuille flow within a slab geometry, and under different anchoring conditions at the wall. Our focus is particularly on the…

Soft Condensed Matter · Physics 2017-02-15 Oliver Wiese , Davide Marenduzzo , Oliver Henrich

We present a computational framework for the simulation of blood flow with fully resolved red blood cells (RBCs) using a modular approach that consists of a lattice Boltzmann solver for the blood plasma, a novel finite element based solver…

Computational Physics · Physics 2019-08-28 Christos Kotsalos , Jonas Latt , Bastien Chopard

In this work we propose a one-class self-supervised method for anomaly segmentation in images that benefits both from a modern machine learning approach and a more classic statistical detection theory. The method consists of four phases.…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Matías Tailanian , Álvaro Pardo , Pablo Musé

Hematopoiesis is the process of blood cell formation, through which progenitor stem cells differentiate into mature forms, such as white and red blood cells or mature platelets. While the precursors of the mature forms share many regulatory…