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Inter and intra-cellular signaling are essential for individual cells to execute various physiological tasks and accurately respond to changes in their environment. Signaling is carried out via diffusible molecules, the transport of which…

Soft Condensed Matter · Physics 2020-10-13 Sumantra Sarkar , Sandeep Choubey

Device-free wireless sensing attracts enormous attentions since it senses the environment without additional devices. While cellular signals are good opportunistic radio sources, the influence of inter-cell interference (ICI) on wireless…

Signal Processing · Electrical Eng. & Systems 2024-01-05 Rui Peng , Yafei Tian , Shengqian Han

Many systems in biology and beyond employ collaborative, collective communication strategies for improved efficiency and adaptive benefit. One such paradigm of particular interest is the community estimation of a dynamic signal, when, for…

Adaptation and Self-Organizing Systems · Physics 2020-07-01 Mohammadreza Bahadorian , Christoph Zechner , Carl Modes

Large-scale distributed learning aims at minimizing a loss function $L$ that depends on a training dataset with respect to a $d$-length parameter vector. The distributed cluster typically consists of a parameter server (PS) and multiple…

Information Theory · Computer Science 2026-03-25 Sifat Munim , Aditya Ramamoorthy

Collective information processing is fundamental in various biological systems, where the cooperation of multiple cells results in complex functions beyond individual capabilities. A distinctive example is collective exploration where…

Cell Behavior · Quantitative Biology 2025-01-03 Masaki Kato , Tetsuya J. Kobayashi

While feed-forward neurons in pre-trained language models (PLMs) can encode knowledge, past research targeted a small subset of neurons that heavily influence outputs. This leaves the broader role of neuron activations unclear, limiting…

Computation and Language · Computer Science 2025-06-03 Xin Zhao , Zehui Jiang , Naoki Yoshinaga

A cell routinely responds to one of many competing environmental cues. A fundamental question is whether the cell follows the cue prioritized by its internal signaling network or the cue that carries the most external information. We…

Biological Physics · Physics 2025-06-26 Louis Gonzalez , Hogyeong Gwak , Bumsoo Han , Andrew Mugler

This paper presents a novel physics-based model for signal propagation in closed-loop molecular communication (MC) systems, which are particularly relevant for many envisioned biomedical applications, such as health monitoring or drug…

Systems and Control · Electrical Eng. & Systems 2025-06-23 Lukas Brand , Fardad Vakilipoor , Sören Botsch , Timo Jakumeit , Sebastian Lotter , Robert Schober , Maximilian Schäfer

Cells constantly need to monitor the state of the environment to detect changes and timely respond. The detection of concentration changes of a ligand by a set of receptors can be cast as a problem of hypothesis testing, and the cell viewed…

Quantitative Methods · Quantitative Biology 2015-09-30 Stefano Bo , Antonio Celani

Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain…

Molecular Networks · Quantitative Biology 2012-05-01 Ilya Nemenman

Feedback in sensory biochemical networks can give rise to bifurcations in cells' behavioral response. These bifurcations share many properties with thermodynamic critical points. Evidence suggests that biological systems may operate near…

Biological Physics · Physics 2020-12-04 Michael Vennettilli , Amir Erez , Andrew Mugler

Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing…

Cell Behavior · Quantitative Biology 2024-08-27 Alan Givré , Alejandro Colman-Lerner , Silvina Ponce Dawson

Accurate gradient sensing is crucial for efficient chemotaxis in noisy environments, but the relationship between cell shape deformations and sensing accuracy is not well understood. Using a theoretical framework based on maximum likelihood…

Biological Physics · Physics 2025-03-07 Daiqiu Mou , Yuansheng Cao

Chemical reaction networks in living cells maintain precise control over thousands of metabolites despite operating far from equilibrium under constant perturbations. While mass action kinetics accurately describe the underlying dynamics,…

Optimization and Control · Mathematics 2025-08-27 Steven Diamond

Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties…

Soft Condensed Matter · Physics 2009-10-31 Chinlin Guo , Herbert Levine

Exploiting the information provided by the molecular noise of a biological process has proven to be valuable in extracting knowledge about the underlying kinetic parameters and sources of variability from single cell measurements. However,…

Quantitative Methods · Quantitative Biology 2013-08-30 Jakob Ruess , Andreas Milias-Argeitis , John Lygeros

Molecular communication between biological entities is a new paradigm in communications. Recently, we studied molecular communication between two nodes formed from synthetic bacteria. Due to high randomness in behavior of bacteria, we used…

Emerging Technologies · Computer Science 2014-10-07 Arash Einolghozati , Mohsen Sardari , Faramarz Fekri

Recently, graph (network) data is an emerging research area in artificial intelligence, machine learning and statistics. In this work, we are interested in whether node's labels (people's responses) are affected by their neighbor's features…

Methodology · Statistics 2022-10-12 Haixiang Zhang , Yingjun Deng , Alan J. X. Guo , Qing-Hu Hou , Ou Wu

Molecular communication (MC) engineering is inspired by the use of chemical signals as information carriers in cell biology. The biological nature of chemical signaling makes MC a promising methodology for interdisciplinary applications…

Emerging Technologies · Computer Science 2020-09-02 Dadi Bi , Apostolos Almpanis , Adam Noel , Yansha Deng , Robert Schober

Lithium ion batteries (LIBs) work under sophisticated external force field and its electrochemical properties could be modulated by strain. Owing to the electro-mechanical coupling, the change of micro-local-structures can greatly affect…

Materials Science · Physics 2021-03-08 Gao Xu , Feng Hao , Mouyi Weng , Jiawang Hong , Feng Pan , Daining Fang