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Predicting genetic perturbations enables the identification of potentially crucial genes prior to wet-lab experiments, significantly improving overall experimental efficiency. Since genes are the foundation of cellular life, building gene…

Quantitative Methods · Quantitative Biology 2025-05-09 Changxi Chi , Jun Xia , Jingbo Zhou , Jiabei Cheng , Chang Yu , Stan Z. Li

Recommender system research has oftentimes focused on approaches that operate on large-scale datasets containing millions of user interactions. However, many small businesses struggle to apply state-of-the-art models due to their very…

One of the most difficult problems difficult problem in systems biology is to discover protein-protein interactions as well as their associated functions. The analysis and alignment of protein-protein interaction networks (PPIN), which are…

Molecular Networks · Quantitative Biology 2019-02-20 Ricardo Alberich , Adrià Alcala , Mercè Llabrés , Francesc Rosselló , Gabriel Valiente

Heterogeneous graph neural networks (HGNNs) have powerful capability to embed rich structural and semantic information of a heterogeneous graph into node representations. Existing HGNNs inherit many mechanisms from graph neural networks…

Machine Learning · Computer Science 2023-09-04 Xiaocheng Yang , Mingyu Yan , Shirui Pan , Xiaochun Ye , Dongrui Fan

Many real-world problems are naturally modeled as heterogeneous graphs, where nodes and edges represent multiple types of entities and relations. Existing learning models for heterogeneous graph representation usually depend on the…

Predicting the bioactivity of a ligand is one of the hardest and most important challenges in computer-aided drug discovery. Despite years of data collection and curation efforts by research organizations worldwide, bioactivity data remains…

Quantitative Methods · Quantitative Biology 2023-08-21 Lucian Chan , Marcel Verdonk , Carl Poelking

Hybrid light fidelity (LiFi) and wireless fidelity (WiFi) networks are a promising paradigm of heterogeneous network (HetNet), attributed to the complementary physical properties of optical spectra and radio frequency. However, the current…

Machine Learning · Computer Science 2025-09-09 Han Ji , Xiping Wu , Zhihong Zeng , Chen Chen

This paper studies the joint user association and resource allocation in heterogeneous networks (HetNets) from a novel perspective, motivated by and generalizing the idea of fractional frequency reuse. By treating the multi-cell multi-user…

Networking and Internet Architecture · Computer Science 2015-11-04 Quan Kuang , Wolfgang Utschick , Andreas Dotzler

Network alignment is a problem of finding the node mapping between similar networks. It links the data from separate sources and is widely studied in bioinformation and social network fields. The critical difference between network…

Social and Information Networks · Computer Science 2021-07-26 Hailong Li , Naiyue Chen

Network alignment, in general, seeks to discover the hidden underlying correspondence between nodes across two (or more) networks when given their network structure. However, most existing network alignment methods have added assumptions of…

Social and Information Networks · Computer Science 2019-02-28 Tyler Derr , Hamid Karimi , Xiaorui Liu , Jiejun Xu , Jiliang Tang

Network embedding aims to learn low-dimensional representations of nodes while capturing structure information of networks. It has achieved great success on many tasks of network analysis such as link prediction and node classification.…

Social and Information Networks · Computer Science 2020-04-03 Hansheng Xue , Luwei Yang , Wen Jiang , Yi Wei , Yi Hu , Yu Lin

The life of the modern world essentially depends on the work of the large artificial homogeneous networks, such as wired and wireless communication systems, networks of roads and pipelines. The support of their effective continuous…

Optimization and Control · Mathematics 2017-01-25 Dmitry Yu. Ignatov , Alexander N. Filippov , Andrey D. Ignatov , Xuecang Zhang

Background: Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide ``reverse engineering'' of such networks have been…

Many real-world graphs (networks) are heterogeneous with different types of nodes and edges. Heterogeneous graph embedding, aiming at learning the low-dimensional node representations of a heterogeneous graph, is vital for various…

Social and Information Networks · Computer Science 2021-12-15 Wentao Xu , Yingce Xia , Weiqing Liu , Jiang Bian , Jian Yin , Tie-Yan Liu

Graph neural network, as a powerful graph representation technique based on deep learning, has shown superior performance and attracted considerable research interest. However, it has not been fully considered in graph neural network for…

Social and Information Networks · Computer Science 2021-01-21 Xiao Wang , Houye Ji , Chuan Shi , Bai Wang , Peng Cui , P. Yu , Yanfang Ye

With many frameworks based on message passing neural networks proposed to predict molecular and bulk properties, machine learning methods have tremendously shifted the paradigms of computational sciences underpinning physics, material…

Machine Learning · Computer Science 2021-09-03 Zun Wang , Chong Wang , Sibo Zhao , Yong Xu , Shaogang Hao , Chang Yu Hsieh , Bing-Lin Gu , Wenhui Duan

Interference coupling in heterogeneous networks introduces the inherent non-convexity to the network resource optimization problem, hindering the development of effective solutions. A new framework based on multi-pattern formulation has…

Networking and Internet Architecture · Computer Science 2016-11-17 Quan Kuang , Xiangbin Yu , Wolfgang Utschick

Graph Neural Networks (GNNs) have recently caught great attention and achieved significant progress in graph-level applications. In this paper, we propose a framework for graph neural networks with multiresolution Haar-like wavelets, or…

Machine Learning · Computer Science 2021-01-26 Xuebin Zheng , Bingxin Zhou , Ming Li , Yu Guang Wang , Junbin Gao

Heterogeneous networks are widely used to model real-world semi-structured data. The key challenge of learning over such networks is the modeling of node similarity under both network structures and contents. To deal with network…

Social and Information Networks · Computer Science 2019-10-04 Carl Yang , Mengxiong Liu , Frank He , Xikun Zhang , Jian Peng , Jiawei Han

This study presents a hierarchical mining framework for high-dimensional imbalanced data, leveraging a depth graph model to address the inherent performance limitations of conventional approaches in handling complex, high-dimensional data…

Machine Learning · Computer Science 2025-02-07 Yijiashun Qi , Quanchao Lu , Shiyu Dou , Xiaoxuan Sun , Muqing Li , Yankaiqi Li