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Receiver operating characteristic (ROC) analysis is a tool to evaluate the capacity of a numeric measure to distinguish between groups, often employed in the evaluation of diagnostic tests. Overall classification ability is sometimes…

We propose new simultaneous inference methods for diagnostic trials with elaborate factorial designs. Instead of the commonly used total area under the receiver operating characteristic (ROC) curve, our parameters of interest are partial…

Statistics Theory · Mathematics 2023-02-22 Maximilian Wechsung , Frank Konietschke

The receiver operating characteristic (ROC) curve is a powerful statistical tool and has been widely applied in medical research. In the ROC curve estimation, a commonly used assumption is that larger the biomarker value, greater severity…

Methodology · Statistics 2023-02-24 Dingding Hu , Meng Yuan , Tao Yu , Pengfei Li

In this review, we present an overview of the main aspects related to the statistical evaluation of medical tests for diagnosis and prognosis. Measures of diagnostic performance for binary tests, such as sensitivity, specificity, and…

Methodology · Statistics 2020-07-16 Vanda Inacio , Maria Xose Rodriguez-Alvarez , Pilar Gayoso-Diz

Many problems that appear in biomedical decision making, such as diagnosing disease and predicting response to treatment, can be expressed as binary classification problems. The costs of false positives and false negatives vary across…

Throughout science and technology, receiver operating characteristic (ROC) curves and associated area under the curve (AUC) measures constitute powerful tools for assessing the predictive abilities of features, markers and tests in binary…

Machine Learning · Statistics 2021-06-25 Tilmann Gneiting , Eva-Maria Walz

The performance of risk prediction models is often characterized in terms of discrimination and calibration. The Receiver Operating Characteristic (ROC) curve is widely used for evaluating model discrimination. When evaluating the…

Methodology · Statistics 2021-10-19 Mohsen Sadatsafavi , Paramita Saha-Chaudhuri , John Petkau

In diagnostic studies, researchers frequently encounter imperfect reference standards with some misclassified labels. Treating these as gold standards can bias receiver operating characteristic (ROC) curve analysis. To address this issue,…

Methodology · Statistics 2025-02-13 Yifan Sun , Peijun Sang , Qinglong Tian , Pengfei Li

The Receiver Operating Characteristic (ROC) curve and the Area Under the Curve (AUC) of the ROC curve are widely used to compare the performance of diagnostic and prognostic assays. The ROC curve has the advantage that it is independent of…

Receiver operating characteristic (ROC) curve is an informative tool in binary classification and Area Under ROC Curve (AUC) is a popular metric for reporting performance of binary classifiers. In this paper, first we present a…

Machine Learning · Computer Science 2021-09-14 Khashayar Namdar , Masoom A. Haider , Farzad Khalvati

The ROC (receiver operating characteristic) curve is a widely used device for assessing decision-making systems. It seems surprising, in view of its history dating back to World War Two, that the assignment of uncertainties to a ROC curve…

Data Analysis, Statistics and Probability · Physics 2024-08-19 M. P. Fewell

Verification bias is a well-known problem that may occur in the evaluation of predictive ability of diagnostic tests. When a binary disease status is considered, various solutions can be found in the literature to correct inference based on…

Methodology · Statistics 2023-04-10 Khanh To Duc , Monica Chiogna , Gianfranco Adimari

The Receiver Operating Characteristic (ROC) curve is a representation of the statistical information discovered in binary classification problems and is a key concept in machine learning and data science. This paper studies the statistical…

Methodology · Statistics 2019-05-09 Kai Feng , Han Hong , Ke Tang , Jingyuan Wang

We have carried out a pilot study on a standard collection of electrocardiograms from patients who suffer from congestive heart failure, and subjects without cardiac pathology, using receiver-operating-characteristic (ROC) analysis. The…

chao-dyn · Physics 2007-05-23 Stefan Thurner , Markus C. Feurstein , Malvin C. Teich

Receiver Operating Characteristic (ROC) curves have recently been used to evaluate the performance of models for spatial presence-absence or presence-only data. Applications include species distribution modelling and mineral prospectivity…

Methodology · Statistics 2025-06-05 Adrian Baddeley , Ege Rubak , Suman Rakshit , Gopalan Nair

Optimal performance is critical for decision-making tasks from medicine to autonomous driving, however common performance measures may be too general or too specific. For binary classifiers, diagnostic tests or prognosis at a timepoint,…

Estimating average human performance has been performed inconsistently in research in diagnostic medicine. This has been particularly apparent in the field of medical artificial intelligence, where humans are often compared against AI…

Methodology · Statistics 2020-09-28 Luke Oakden-Rayner , Lyle Palmer

The identification of biomarkers with high predictive accuracy is a crucial task in medical research, as it can aid clinicians in making early decisions, thereby reducing morbidity and mortality in high-risk populations. Time-dependent…

Methodology · Statistics 2025-10-22 María Xosé Rodríguez-Álvarez , Vanda Inácio

Receiver-operating-characteristic (ROC) analysis was used to assess the suitability of various heart rate variability (HRV) measures for correctly classifying electrocardiogram records of varying lengths as normal or revealing the presence…

Medical Physics · Physics 2019-10-23 Stefan Thurner , Markus C. Feurstein , Steven B. Lowen , Malvin C. Teich

Paired comparison models are used for analyzing data that involves pairwise comparisons among a set of objects. When the outcomes of the pairwise comparisons have no ties, the paired comparison models can be generalized as a class of binary…

Methodology · Statistics 2022-11-29 Ran Huo , Mark E. Glickman