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Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, drug discovery, as well as drug resistance and side-effect prediction. DTI identification using machine learning is gaining…

Quantitative Methods · Quantitative Biology 2023-11-17 Konstantin Y. Kalitin , Alexey A. Nevzorov , Denis A. Babkov , Alexander A. Spasov , Olga Y. Mukha

The impact of repetitive transcranial magnetic stimulation (rTMS) on methamphetamine (METH) users' craving levels is often assessed using questionnaires. This study explores the feasibility of using neural signals to obtain more objective…

Neurons and Cognition · Quantitative Biology 2025-09-29 Ziyi Zeng , Yun-Hsuan Chen , Xurong Gao , Wenyao Zheng , Hemmings Wu , Zhoule Zhu , Jie Yang , Chengkai Wang , Lihua Zhong , Weiwei Cheng , Mohamad Sawan

Objective. Covert aspects of ongoing user mental states provide key context information for user-aware human computer interactions. In this paper, we focus on the problem of estimating the vigilance of users using EEG and EOG signals.…

Human-Computer Interaction · Computer Science 2016-11-28 Wei-Long Zheng , Bao-Liang Lu

Timely and objective screening of major depressive disorder (MDD) is vital, yet diagnosis still relies on subjective scales. Electroencephalography (EEG) provides a low-cost biomarker, but existing deep models treat spectra as static…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Jingru Qiu , Jiale Liang , Xuanhan Fan , Mingda Zhang , Zhenli He

The present literature about possible mechanisms behind the effectivity of noninvasive electromagnetic stimulation in major depressive disorder (MDD) is not very rich. Despite extensive research in applications for clinical practice, the…

Neurons and Cognition · Quantitative Biology 2019-12-19 Milena Cukic

Emotion recognition has significant potential in healthcare and affect-sensitive systems such as brain-computer interfaces (BCIs). However, challenges such as the high cost of labeled data and variability in electroencephalogram (EEG)…

Signal Processing · Electrical Eng. & Systems 2024-11-21 Md Niaz Imtiaz , Naimul Khan

Currently, approximately 30% of epileptic patients treated with antiepileptic drugs (AEDs) remain resistant to treatment (known as refractory patients). This project seeks to understand the underlying similarities in refractory patients vs.…

Machine Learning · Computer Science 2017-04-28 David Von Dollen

Identifying neural markers of stress and cognitive load is key to developing scalable tools for mental state assessment. This study evaluated whether a single-channel high-density EEG (hdrEEG) system could dissociate cognitive and…

Neurons and Cognition · Quantitative Biology 2025-07-15 Neta Batya Maimon , Lior Molcho , Talya Zaimer , Ofir Chibotero , Nathan Intrator , Eliezer Yahalom

Electroencephalography (EEG) is commonly used by physicians for the diagnosis of numerous neurological disorders. Due to the large volume of EEGs requiring interpretation and the specific expertise involved, artificial intelligence-based…

Simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) is an emerging neuromodulation approach, that enables simultaneous volitional regulation of both hemodynamic (BOLD fMRI) and electrophysiological (EEG) brain activities. Here…

Neurons and Cognition · Quantitative Biology 2020-07-06 Vadim Zotev , Ahmad Mayeli , Masaya Misaki , Jerzy Bodurka

Electroencephalography (EEG) provides a non-invasive, highly accessible, and cost-effective approach for detecting Alzheimer's disease (AD). However, existing methods, whether based on handcrafted feature engineering or standard deep…

Machine Learning · Computer Science 2026-02-03 Yihe Wang , Nan Huang , Nadia Mammone , Marco Cecchi , Xiang Zhang

Motivated behaviour relies on the brain's capacity to evaluate effort and reward. Dysregulation within these processes contributes to a spectrum of conditions, from hyperactivity in attention-deficit/hyperactivity disorder (ADHD) to…

Neurons and Cognition · Quantitative Biology 2026-04-20 Nam Trinh

According to the World Health Organization, the number of mental disorder patients, especially depression patients, has grown rapidly and become a leading contributor to the global burden of disease. However, the present common practice of…

This paper presents the very first attempt to evaluate machine learning fairness for depression detection using electroencephalogram (EEG) data. We conduct experiments using different deep learning architectures such as Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Angus Man Ho Kwok , Jiaee Cheong , Sinan Kalkan , Hatice Gunes

Rapid triage of suspected stroke needs accurate, bedside-deployable tools; EEG is promising but underused at first contact. We present an adaptive multitask EEG classifier that converts 32-channel signals to power spectral density features…

Machine Learning · Computer Science 2025-11-13 Shakeel Abdulkareem , Bora Yimenicioglu , Khartik Uppalapati , Aneesh Gudipati , Adan Eftekhari , Saleh Yassin

Real-time fMRI neurofeedback (rtfMRI-nf) is an emerging approach for studies and novel treatments of major depressive disorder (MDD). EEG performed simultaneously with an rtfMRI-nf procedure allows an independent evaluation of rtfMRI-nf…

A major shortcoming of medical practice is the lack of an objective measure of conscious level. Impairment of consciousness is common, e.g. following brain injury and seizures, which can also interfere with sensory processing and volitional…

Neurons and Cognition · Quantitative Biology 2025-12-24 Alexis Pomares Pastor , Ines Ribeiro Violante , Gregory Scott

The increasing quality and affordability of consumer electroencephalogram (EEG) headsets make them attractive for situations where medical grade devices are impractical. Predicting and tracking cognitive states is possible for tasks that…

Computer Vision and Pattern Recognition · Computer Science 2016-06-07 Pouya Bashivan , Irina Rish , Steve Heisig

As the world's first primary morbidity factor, depression has a considerable impact on both an individual as well as a societal level. despite their discovery several decades ago, classical antidepressants have been shown to provide limited…

Quantitative Methods · Quantitative Biology 2020-07-17 Camile Bahi

Intracranial EEG (IEEG) is used for 2 main purposes, to determine: (1) if epileptic networks are amenable to focal treatment and (2) where to intervene. Currently these questions are answered qualitatively and sometimes differently across…