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The relationship between sequences and secondary structures or shapes in RNA exhibits robust statistical properties summarized by three notions: (1) the notion of a typical shape (that among all sequences of fixed length certain shapes are…

Biological Physics · Physics 2009-10-31 Peter Schuster , Walter Fontana

We study the inference of network archaeology in growing random geometric graphs. We consider the root finding problem for a random nearest neighbor tree in dimension $d \in \mathbb{N}$, generated by sequentially embedding vertices…

Probability · Mathematics 2024-11-22 Anna Brandenberger , Cassandra Marcussen , Elchanan Mossel , Madhu Sudan

Many natural phenomena are quantified by counts of observable events, from the annihilation of quasiparticles in a lattice to predator-prey encounters on a landscape to spikes in a neural network. These events are triggered at random…

Time series data analytics has been a problem of substantial interests for decades, and Dynamic Time Warping (DTW) has been the most widely adopted technique to measure dissimilarity between time series. A number of global-alignment kernels…

Machine Learning · Computer Science 2018-09-17 Lingfei Wu , Ian En-Hsu Yen , Jinfeng Yi , Fangli Xu , Qi Lei , Michael Witbrock

We consider the problem of detecting a random walk on a graph, based on observations of the graph nodes. When visited by the walk, each node of the graph observes a signal of elevated mean, which we assume can be different across different…

Information Theory · Computer Science 2018-10-03 Dragana Bajovic , José M. F. Moura , Dejan Vukobratovic

An RNA sequence is a word over an alphabet on four elements $\{A,C,G,U\}$ called bases. RNA sequences fold into secondary structures where some bases match one another while others remain unpaired. Pseudoknot-free secondary structures can…

Data Structures and Algorithms · Computer Science 2018-03-28 Édouard Bonnet , Paweł Rzążewski , Florian Sikora

Excited random walks (ERWs) are a self-interacting non-Markovian random walk in which the future behavior of the walk is influenced by the number of times the walk has previously visited its current site. We study the speed of the walk,…

Probability · Mathematics 2018-06-06 Erin Bossen , Brian Kidd , Owen Levin , Jonathon Peterson , Jacob Smith , Kevin Stangl

We investigate the relation between the local picture left by the trajectory of a simple random walk on the torus (Z/NZ)^d, d >= 3, until u N^d time steps, u > 0, and the model of random interlacements recently introduced by Sznitman. In…

Probability · Mathematics 2009-07-22 David Windisch

We consider the hypothesis that Evolution promotes population-wide genome patterns that, under randomization, ensures the External Validity of adaptations across population members. An adaptation is Externally Valid (EV) if its effect holds…

Populations and Evolution · Quantitative Biology 2021-08-17 Andre F. Ribeiro

The so called long range correlation properties of DNA sequences are studied using the variance analyses of the density distribution of a single or a group of nucleotides in a model independent way. This new method which was suggested…

Biological Physics · Physics 2007-05-23 A. K. Mohanty , A. V. S. S. Narayana Rao

The weights of a neural network are typically initialized at random, and one can think of the functions produced by such a network as having been generated by a prior over some function space. Studying random networks, then, is useful for a…

Machine Learning · Statistics 2018-11-28 Kevin K. Chen , Anthony C. Gamst , Alden K. Walker

We propose a procedure to generate dynamical networks with bursty, possibly repetitive and correlated temporal behaviors. Regarding any weighted directed graph as being composed of the accumulation of paths between its nodes, our…

Physics and Society · Physics 2013-04-10 Alain Barrat , Bastien Fernandez , Kevin K Lin , Lai-Sang Young

We study variable-speed random walks on $\mathbb Z$ driven by a family of nearest-neighbor time-dependent random conductances $\{a_t(x,x+1)\colon x\in\mathbb Z, t\ge0\}$ whose law is assumed invariant and ergodic under space-time shifts. We…

Probability · Mathematics 2020-01-06 Marek Biskup

Inspired by the study of edge statistics of random band matrices, we investigate random walks on large $d$-dimensional periodic lattices, whose transition matrices are determined by discretized density functions. Under certain moment…

Probability · Mathematics 2024-11-07 Yandong Gu , Dang-Zheng Liu

Bounds on the entropy of patterns of sequences generated by independently identically distributed (i.i.d.) sources are derived. A pattern is a sequence of indices that contains all consecutive integer indices in increasing order of first…

Information Theory · Computer Science 2007-07-13 Gil I. Shamir

Gene duplication is a fundamental evolutionary mechanism that contributes to biological complexity and diversity (Fortna et al., 2004). Traditionally, research has focused on the duplication of gene sequences (Zhang, 1914). However,…

Molecular Networks · Quantitative Biology 2024-05-07 Ashley Scruse , Jonathan Arnold , Robert Robinson

Thousands of candidate human-specific regulatory sequences (HSRS) have been identified, supporting the hypothesis that unique to human phenotypes result from human-specific alterations of genomic regulatory networks. Here, conservation…

Genomics · Quantitative Biology 2025-12-30 Gennadi Glinsky

In this paper we study two natural models of \textit{random temporal} graphs. In the first, the \textit{continuous} model, each edge $e$ is assigned $l_e$ labels, each drawn uniformly at random from $(0,1]$, where the numbers $l_e$ are…

Discrete Mathematics · Computer Science 2026-02-12 Henry Austin , George B. Mertzios , Paul G. Spirakis

Our paper gives bounds for the rate of convergence for a class of random walks on the d-dimensional torus generated by a set of n vectors in R^d/Z^d. We give bounds on the discrepancy distance from Haar measure; our lower bound holds for…

Probability · Mathematics 2007-05-23 Timothy Prescott , Francis Edward Su

A quantitative theory on the construction and the evolution of the genetic code is proposed. Through introducing the concept of mutational deterioration (MD) and developing a theoretical formalism on MD minimization we have proved: 1, the…

Other Quantitative Biology · Quantitative Biology 2009-08-24 Liaofu Luo