An Experimental-Design Perspective on Population Genetic Variation
Populations and Evolution
2021-08-17 v1
Abstract
We consider the hypothesis that Evolution promotes population-wide genome patterns that, under randomization, ensures the External Validity of adaptations across population members. An adaptation is Externally Valid (EV) if its effect holds under a wide range of population genetic variations. A prediction following the hypothesis is that pairwise base substitutions in segregating regions must be 'random' as in Erdos-Renyi-Gilbert random graphs, but with edge probabilities derived from Experimental-Design concepts. We demonstrate these probabilities, and consequent mutation rates, in the full-genomes of 2504 humans, 1135 flowering plants, 1170 flies, 453 domestic sheep and 1223 brown rats.
Cite
@article{arxiv.2108.06580,
title = {An Experimental-Design Perspective on Population Genetic Variation},
author = {Andre F. Ribeiro},
journal= {arXiv preprint arXiv:2108.06580},
year = {2021}
}