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Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used…

Quantitative Methods · Quantitative Biology 2018-08-10 Mahtab Ahmed , Jumayel Islam , Muhammad Rifayat Samee , Robert E. Mercer

The Learnable Tree Filter presents a remarkable approach to model structure-preserving relations for semantic segmentation. Nevertheless, the intrinsic geometric constraint forces it to focus on the regions with close spatial distance,…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Lin Song , Yanwei Li , Zhengkai Jiang , Zeming Li , Xiangyu Zhang , Hongbin Sun , Jian Sun , Nanning Zheng

Incorporating syntactic information in Neural Machine Translation models is a method to compensate their requirement for a large amount of parallel training text, especially for low-resource language pairs. Previous works on using syntactic…

Computation and Language · Computer Science 2017-11-27 Poorya Zaremoodi , Gholamreza Haffari

Grammatical relationships are an important level of natural language processing. We present a trainable approach to find these relationships through transformation sequences and error-driven learning. Our approach finds grammatical…

Computation and Language · Computer Science 2007-05-23 Lisa Ferro , Marc Vilain , Alexander Yeh

Recent advances in data-driven models for grounded language understanding have enabled robots to interpret increasingly complex instructions. Two fundamental limitations of these methods are that most require a full model of the environment…

Robotics · Computer Science 2019-10-23 Siddharth Patki , Ethan Fahnestock , Thomas M. Howard , Matthew R. Walter

Multimodal approaches that integrate protein structure and sequence have achieved remarkable success in protein-protein interface prediction. However, extending these methods to protein-peptide interactions remains challenging due to the…

Signal Processing · Electrical Eng. & Systems 2025-11-03 Dian Chen , Yunkai Chen , Tong Lin , Sijie Chen , Xiaolin Cheng

Predicting protein structure from the amino acid sequence has been a challenge with theoretical and practical significance in biophysics. Despite the recent progresses elicited by improved residue-residue contact prediction, contact-based…

Biomolecules · Quantitative Biology 2019-12-19 Wenze Ding , Haipeng Gong

Protein contacts provide key information for the understanding of protein structure and function, and therefore contact prediction from sequences is an important problem. Recent research shows that some correctly predicted long-range…

Quantitative Methods · Quantitative Biology 2020-09-02 Siqi Sun

This thesis investigates how the sub-structure of words can be accounted for in probabilistic models of language. Such models play an important role in natural language processing tasks such as translation or speech recognition, but often…

Computation and Language · Computer Science 2015-08-19 Jan A. Botha

Neural networks with tree-based sentence encoders have shown better results on many downstream tasks. Most of existing tree-based encoders adopt syntactic parsing trees as the explicit structure prior. To study the effectiveness of…

Computation and Language · Computer Science 2018-08-30 Haoyue Shi , Hao Zhou , Jiaze Chen , Lei Li

Large protein language models are adept at capturing the underlying evolutionary information in primary structures, offering significant practical value for protein engineering. Compared to natural language models, protein amino acid…

Computation and Language · Computer Science 2023-10-27 Yang Tan , Mingchen Li , Pan Tan , Ziyi Zhou , Huiqun Yu , Guisheng Fan , Liang Hong

Latent variable models are an elegant framework for capturing rich probabilistic dependencies in many applications. However, current approaches typically parametrize these models using conditional probability tables, and learning relies…

Machine Learning · Computer Science 2012-10-19 Ankur P. Parikh , Le Song , Mariya Ishteva , Gabi Teodoru , Eric P. Xing

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates…

Machine Learning · Computer Science 2024-10-18 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

The goal of protein representation learning is to extract knowledge from protein databases that can be applied to various protein-related downstream tasks. Although protein sequence, structure, and function are the three key modalities for…

Biomolecules · Quantitative Biology 2024-05-14 Eunji Ko , Seul Lee , Minseon Kim , Dongki Kim

Protein language models (PLMs) have shown promise in improving the understanding of protein sequences, contributing to advances in areas such as function prediction and protein engineering. However, training these models from scratch…

Machine Learning · Computer Science 2024-12-19 Shivasankaran Vanaja Pandi , Bharath Ramsundar

Protein language models (PLMs) learn probability distributions over natural protein sequences. By learning from hundreds of millions of natural protein sequences, protein understanding and design capabilities emerge. Recent works have shown…

Quantitative Methods · Quantitative Biology 2026-02-27 Timothy Fei Truong , Tristan Bepler

Syntactic structures used to play a vital role in natural language processing (NLP), but since the deep learning revolution, NLP has been gradually dominated by neural models that do not consider syntactic structures in their design. One…

Computation and Language · Computer Science 2023-11-28 Haoyi Wu , Kewei Tu

We describe a corpus-based induction algorithm for probabilistic context-free grammars. The algorithm employs a greedy heuristic search within a Bayesian framework, and a post-pass using the Inside-Outside algorithm. We compare the…

cmp-lg · Computer Science 2008-02-03 Stanley F. Chen

While long short-term memory (LSTM) neural net architectures are designed to capture sequence information, human language is generally composed of hierarchical structures. This raises the question as to whether LSTMs can learn hierarchical…

Computation and Language · Computer Science 2018-11-08 Luzi Sennhauser , Robert C. Berwick

We propose a weakly-supervised approach that takes image-sentence pairs as input and learns to visually ground (i.e., localize) arbitrary linguistic phrases, in the form of spatial attention masks. Specifically, the model is trained with…

Computer Vision and Pattern Recognition · Computer Science 2017-05-04 Fanyi Xiao , Leonid Sigal , Yong Jae Lee