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Structural dynamics of macromolecules is critical to their structural-function relationship. Cryogenic electron microscopy (CryoEM) provides snapshots of vitrified protein at different compositional and conformational states, and the…

Quantitative Methods · Quantitative Biology 2026-01-27 Muyuan Chen , Muchen Li , Renjie Liao

Cell segmentation is a major bottleneck in extracting quantitative single-cell information from microscopy data. The challenge is exasperated in the setting of microstructured environments. While deep learning approaches have proven useful…

Quantitative Methods · Quantitative Biology 2021-01-08 Tim Prangemeier , Christian Wildner , André O. Françani , Christoph Reich , Heinz Koeppl

Multi-task learning has recently emerged as a promising solution for a comprehensive understanding of complex scenes. In addition to being memory-efficient, multi-task models, when appropriately designed, can facilitate the exchange of…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Ivan Lopes , Tuan-Hung Vu , Raoul de Charette

We propose a cell segmentation method for analyzing images of densely clustered cells. The method combines the strengths of marker-controlled watershed transformation and a convolutional neural network (CNN). We demonstrate the method…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Filip Lux , Petr Matula

Deep convolutional neural network (CNN) achieves remarkable performance for medical image analysis. UNet is the primary source in the performance of 3D CNN architectures for medical imaging tasks, including brain tumor segmentation. The…

Image and Video Processing · Electrical Eng. & Systems 2020-11-30 Parvez Ahmad , Saqib Qamar , Linlin Shen , Adnan Saeed

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

Detection and classification of pulmonary nodules is a challenge in medical image analysis due to the variety of shapes and sizes of nodules and their high concealment. Despite the success of traditional deep learning methods in image…

Image and Video Processing · Electrical Eng. & Systems 2025-02-28 Junji Lin , Yi Zhang , Yunyue Pan , Yuli Chen , Chengchang Pan , Honggang Qi

Ultrafast diffraction imaging is a powerful tool to retrieve the geometric structure of gas-phase molecules with combined picometre spatial and attosecond temporal resolution. However, structural retrieval becomes progressively difficult…

Chemical Physics · Physics 2021-10-13 Xinyao Liu , Kasra Amini , Aurelien Sanchez , Blanca Belsa , Tobias Steinle , Jens Biegert

Multi-task learning improves generalization performance by sharing knowledge among related tasks. Existing models are for task combinations annotated on the same dataset, while there are cases where multiple datasets are available for each…

Computer Vision and Pattern Recognition · Computer Science 2018-05-16 Seiichiro Fukuda , Ryota Yoshihashi , Rei Kawakami , Shaodi You , Makoto Iida , Takeshi Naemura

Machine-learning-based methods can be developed for the reconstruction of clusters in segmented detectors for high energy physics experiments. Convolutional neural networks with autoencoder architecture trained on labeled data from a…

Instrumentation and Detectors · Physics 2025-06-02 Kalina Dimitrova , Venelin Kozhuharov , Ruslan Nastaev , Peicho Petkov

This paper presents a new regularization method to train a fully convolutional network for semantic tissue segmentation in histopathological images. This method relies on the benefit of unsupervised learning, in the form of image…

Computer Vision and Pattern Recognition · Computer Science 2020-11-26 C. T. Sari , C. Sokmensuer , C. Gunduz-Demir

Obtaining annotations for 3D medical images is expensive and time-consuming, despite its importance for automating segmentation tasks. Although multi-task learning is considered an effective method for training segmentation models using…

Computer Vision and Pattern Recognition · Computer Science 2020-09-24 Junichiro Iwasawa , Yuichiro Hirano , Yohei Sugawara

Restoring images affected by various types of degradation, such as noise, blur, or improper exposure, remains a significant challenge in computer vision. While recent trends favor complex monolithic all-in-one architectures, these models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Joanna Wiekiera , Martyna Zur

Colonoscopy screening is the gold standard procedure for assessing abnormalities in the colon and rectum, such as ulcers and cancerous polyps. Measuring the abnormal mucosal area and its 3D reconstruction can help quantify the surveyed area…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Pedro Esteban Chavarrias Solano , Andrew Bulpitt , Venkataraman Subramanian , Sharib Ali

Cryo-electron tomography (cryo-ET) provides a unique window into molecular organization in cellular environments (in situ). However, the interpretation of molecular structural information is complicated by several intrinsic properties of…

Biomolecules · Quantitative Biology 2026-02-17 Slavica Jonic

Cryo-electron microscopy (cryo-EM) is an experimental technique for protein structure determination that images an ensemble of macromolecules in near-physiological contexts. While recent advances enable the reconstruction of dynamic…

For many biological image segmentation tasks, including topological knowledge, such as the nesting of classes, can greatly improve results. However, most `out-of-the-box' CNN models are still blind to such prior information. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-22 Marie Piraud , Anjany Sekuboyina , Bjoern H. Menze

Representing and reasoning about 3D structures of macromolecules is emerging as a distinct challenge in machine learning. Here, we extend recent work on geometric vector perceptrons and apply equivariant graph neural networks to a wide…

Machine Learning · Computer Science 2021-07-14 Bowen Jing , Stephan Eismann , Pratham N. Soni , Ron O. Dror

A systematic analysis of the cell behavior requires automated approaches for cell segmentation and tracking. While deep learning has been successfully applied for the task of cell segmentation, there are few approaches for simultaneous cell…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Katharina Löffler , Ralf Mikut

In the domain of battery research, the processing of high-resolution microscopy images is a challenging task, as it involves dealing with complex images and requires a prior understanding of the components involved. The utilization of deep…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Ganesh Raghavendran , Bing Han , Fortune Adekogbe , Shuang Bai , Bingyu Lu , William Wu , Minghao Zhang , Ying Shirley Meng