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The dynamics of biomolecules are crucial for our understanding of their functioning in living systems. However, current 3D imaging techniques, such as cryogenic electron microscopy (cryo-EM), require freezing the sample, which limits the…

Quantitative Methods · Quantitative Biology 2023-08-24 Enze Ye , Yuhang Wang , Hong Zhang , Yiqin Gao , Huan Wang , He Sun

The prospect of neural reconstruction from Electron Microscopy (EM) images has been elucidated by the automatic segmentation algorithms. Although segmentation algorithms eliminate the necessity of tracing the neurons by hand, significant…

Computer Vision and Pattern Recognition · Computer Science 2015-09-29 Toufiq Parag

Semantic segmentation of electron microscopy (EM) is an essential step to efficiently obtain reliable morphological statistics. Despite the great success achieved using deep convolutional neural networks (CNNs), they still produce coarse…

Computer Vision and Pattern Recognition · Computer Science 2021-01-11 Zhimin Yuan , Xiaofen Ma , Jiajin Yi , Zhengrong Luo , Jialin Peng

Curvilinear structures frequently appear in microscopy imaging as the object of interest. Crystallographic defects, i.e., dislocations, are one of the curvilinear structures that have been repeatedly investigated under transmission electron…

Image and Video Processing · Electrical Eng. & Systems 2021-10-19 Okan Altingövde , Anastasiia Mishchuk , Gulnaz Ganeeva , Emad Oveisi , Cecile Hebert , Pascal Fua

Deep learning methods have surpassed the performance of traditional techniques on a wide range of problems in computer vision, but nearly all of this work has studied consumer photos, where precisely correct output is often not critical. It…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Mingze Xu , Chenyou Fan , John D Paden , Geoffrey C Fox , David J Crandall

Dual-energy computed tomography (DECT) is an advanced CT scanning technique enabling material characterization not possible with conventional CT scans. It allows the reconstruction of energy decay curves at each 3D image voxel, representing…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Segolene Brivet , Faicel Chamroukhi , Mark Coates , Reza Forghani , Peter Savadjiev

Single-particle cryo-EM has transformed structural biology but still faces challenges in resolving conformational heterogeneity at atomic resolution. Existing cryo-EM heterogeneity analysis methods either lack atomic details or tend to…

Biomolecules · Quantitative Biology 2025-10-21 Chengwei Zhang , Shimian Li , Yihao Niu , Zhen Zhu , Sihao Yuan , Sirui Liu , Yi Qin Gao

Automated emotion recognition in the wild from facial images remains a challenging problem. Although recent advances in Deep Learning have supposed a significant breakthrough in this topic, strong changes in pose, orientation and point of…

Computer Vision and Pattern Recognition · Computer Science 2018-02-20 Gerard Pons , David Masip

Molecular representation learning has attracted much attention recently. A molecule can be viewed as a 2D graph with nodes/atoms connected by edges/bonds, and can also be represented by a 3D conformation with 3-dimensional coordinates of…

Machine Learning · Computer Science 2022-07-20 Jinhua Zhu , Yingce Xia , Lijun Wu , Shufang Xie , Tao Qin , Wengang Zhou , Houqiang Li , Tie-Yan Liu

Background and Objectives: Predicting patient response to treatment and survival in oncology is a prominent way towards precision medicine. To that end, radiomics was proposed as a field of study where images are used instead of invasive…

Image and Video Processing · Electrical Eng. & Systems 2022-03-02 Amine Amyar , Romain Modzelewski , Pierre Vera , Vincent Morard , Su Ruan

Automatic lesion detection and segmentation from [${}^{18}$F]FDG PET/CT scans is a challenging task, due to the diversity of shapes, sizes, FDG uptake and location they may present, besides the fact that physiological uptake is also present…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Yamila Rotstein Habarnau , Mauro Namías

Computed tomography (CT) is a widely used non-invasive diagnostic method in various fields, and recent advances in deep learning have led to significant progress in CT image reconstruction. However, the lack of large-scale, open-access…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Maximilian B. Kiss , Ander Biguri , Zakhar Shumaylov , Ferdia Sherry , K. Joost Batenburg , Carola-Bibiane Schönlieb , Felix Lucka

Cryo-electron microscopy (cryo-EM) has revolutionized experimental protein structure determination. Despite advances in high resolution reconstruction, a majority of cryo-EM experiments provide either a single state of the studied…

Single-particle cryo-electron microscopy (cryo-EM) has become one of the mainstream structural biology techniques because of its ability to determine high-resolution structures of dynamic bio-molecules. However, cryo-EM data acquisition…

Machine Learning · Computer Science 2022-04-18 Quanfu Fan , Yilai Li , Yuguang Yao , John Cohn , Sijia Liu , Seychelle M. Vos , Michael A. Cianfrocco

Multi-organ segmentation in whole-body computed tomography (CT) is a constant pre-processing step which finds its application in organ-specific image retrieval, radiotherapy planning, and interventional image analysis. We address this…

Computer Vision and Pattern Recognition · Computer Science 2019-08-15 Fernando Navarro , Suprosanna Shit , Ivan Ezhov , Johannes Paetzold , Andrei Gafita , Jan Peeken , Stephanie Combs , Bjoern Menze

Multi-task learning is a natural approach for computer vision applications that require the simultaneous solution of several distinct but related problems, e.g. object detection, classification, tracking of multiple agents, or denoising, to…

Machine Learning · Computer Science 2015-04-14 Carlo Ciliberto , Lorenzo Rosasco , Silvia Villa

We consider the multi-target detection problem of recovering a set of signals that appear multiple times at unknown locations in a noisy measurement. In the low noise regime, one can estimate the signals by first detecting occurrences, then…

Information Theory · Computer Science 2020-01-08 Tamir Bendory , Nicolas Boumal , William Leeb , Eitan Levin , Amit Singer

We refine the OrbNet model to accurately predict energy, forces, and other response properties for molecules using a graph neural-network architecture based on features from low-cost approximated quantum operators in the symmetry-adapted…

Cryo-electron microscopy (cryo-EM) allows for the high-resolution reconstruction of 3D structures of proteins and other biomolecules. Successful reconstruction of both shape and movement greatly helps understand the fundamental processes of…

Computer Vision and Pattern Recognition · Computer Science 2023-10-12 Xinhang Liu , Yan Zeng , Yifan Qin , Hao Li , Jiakai Zhang , Lan Xu , Jingyi Yu

Pulmonary nodule detection, false positive reduction and segmentation represent three of the most common tasks in the computeraided analysis of chest CT images. Methods have been proposed for eachtask with deep learning based methods…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Hao Tang , Chupeng Zhang , Xiaohui Xie