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Cold atmospheric plasma (CAP) has been emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this…

Medical Physics · Physics 2016-12-21 Zhitong Chen , Xiaoqian Cheng , Li Lin , Michael Keidar

Cold atmospheric plasma (CAP) was shown to affect cells not only directly, but also indirectly by means of plasma pre-treated solution. This study investigated a new application of CAP generated in deionized (DI) water for the cancer…

Medical Physics · Physics 2016-10-17 Zhitong Chen , Li Lin , Xiaoqian Cheng , Eda Gjika , Michael Keidar

Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a potentially safe atmospheric pressure plasma jet device that displays antitumoral…

In recent years, cold atmospheric plasma (CAP) using inert gas has been successfully applied for biomedicine, such as sterilization, wound healing, skin diseases, and tumor treatment. Here, we reported air cold atmospheric plasma with three…

Hydrogen peroxide (H2O2) is an important signaling molecule in cancer cells. However, the significant secretion of H2O2 by cancer cells have been rarely observed. Cold atmospheric plasma (CAP) is a near room temperature ionized gas composed…

Cell Behavior · Quantitative Biology 2017-07-04 Dayun Yan , Haitao Cui , Wei Zhu , Annie Talbot , Lijie Grace Zhang , Jonathan H. Sherman , Michael Keidar

Cold atmospheric plasma (CAP) is a near room temperature ionized gas, generated under non-equilibrium discharge conditions. Here we show that a short exposure of rat peritoneal exudate macrophages and T-cells to CAP in vitro, triggered an…

Medical Physics · Physics 2022-02-01 Fengdong Cheng , Dayun Yan , Jie Chen , Zi Wang , Alex Horkowitz , Michael Keidar , Eduardo M. Sotomayor

For years, extensive efforts have been made to discover effective, non-invasive anti-cancer therapies. Cold atmospheric plasma (CAP), is a near room temperature ionized gas composed of reactive species, charged particles, neutral particles,…

Cold atmospheric plasma (CAP) has shown its promising application in cancer treatment both in vitro and in vivo. However, the anti-cancer mechanism is still largely unknown. CAP may kill cancer cells via triggering the rise of intracellular…

Cell Behavior · Quantitative Biology 2017-11-27 Dayun Yan , Jonathan H. Sherman , Jerome Canady , Barry Trink , Michael Keidar

Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in…

Molecular Networks · Quantitative Biology 2020-10-28 Charlotta Bengtson , Annemie Bogaerts

Plasma medicine is an emerging and innovative interdisciplinary research field combining biology, chemistry, physics, engineering, and medicine. However, the safe clinical application of cold atmospheric plasma (CAP) technology is still a…

Medical Physics · Physics 2023-05-31 Zhitong Chen , Richard Obenchain , Richard E. Wirz

Plasma activated medium, containing reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been used for cancer treatment as an indirect treatment method. Here we report cold atmospheric plasma (CAP) activated deionized (DI)…

Biological Physics · Physics 2022-03-14 Zhitong Chen

Studies on the interaction of plasma generated at atmospheric pressure and at room temperature (low temperature plasma or just cold plasma) with biological cells and tissues have revealed that cold plasma has therapeutic effects that form…

Medical Physics · Physics 2021-06-04 Mounir Laroussi

Inactivation of microorganisms on sensitive surfaces by cold atmospheric plasma (CAP) is one major application in the field of plasma medicine because it provides a simple and effective way to sterilize heat-sensitive materials. Therefore,…

Plasma Physics · Physics 2020-08-26 Sandra Moritz , Alisa Schmidt , Joachim Sann , M. H. Thoma

Cold atmospheric plasmas (CAP) are weakly ionized gases that can be generated in ambient air. They produce energetic species (e.g. electrons, metastables) as well as reactive oxygen species, reactive nitrogen species, UV radiations and…

Applied Physics · Physics 2018-02-21 Florian Judée , Stéphane Simon , Christophe Bailly , Thierry Dufour

Despite advancements in lung cancer therapy, the prognosis for advanced or metastatic patients remains poor, yet many patients eventually develop resistance to standard treatments leading to disease progression and poor survival. Here, we…

Biological Physics · Physics 2024-08-23 Yueye Huang , Rui Zhang , Xiao Chen , Fei Cao , Qiujie Fang , Qingnan Xu , Shicong Huang , Yufan Wang , Guojun Chen , Zhitong Chen

Non-thermal atmospheric plasma (NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. Even though studies report on the successful use of NTAP to directly irradiate cancer cells, this technology can…

Tissues and Organs · Quantitative Biology 2016-09-09 Zhitong Chen , Li Lin , Xiaoqian Cheng , Eda Gjika , Michael Keidar

Cold atmospheric plasma (CAP) and plasma-treated liquids (PTLs) have recently become a promising option for cancer treatment, but the underlying mechanisms of the anti-cancer effect are still to a large extent unknown. Although hydrogen…

Molecular Networks · Quantitative Biology 2021-05-12 Charlotta Bengtson , Annemie Bogaerts

Breast cancer is a disease in which cells in the breast grow out of control. After surgery, chemotherapy, and other invasive treatments, hyperthermia is a suitable choice with the minimal side effects. In this paper, the treatment of breast…

Efficient and biologically safe mode of cold atmospheric plasma jet (CAPJ) is crucial for the development of CAPJ-based anticancer therapy. In the experiment and numerical simulations, by changing the pulse duration of a positive-pulsed…

Cold piezoelectric plasma (CPP) is a novel approach in cancer therapy, enabling the development of portable treatment devices capable of triggering cancer cell death. While its effectiveness remains underexplored, this research focuses on…

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