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Progress in Type 1 Diabetes (T1D) algorithm development is limited by the fragmentation and lack of standardization across existing T1D management datasets. Current datasets differ substantially in structure and are time-consuming to access…

Machine Learning · Computer Science 2026-04-23 Miriam K. Wolff , Peter Calhoun , Eleonora Maria Aiello , Yao Qin , Sam F. Royston

The paper deals with the problem of output regulation of nonlinear systems by presenting a learning-based adaptive internal model-based design strategy. We borrow from the adaptive internal model design technique recently proposed in [1]…

Systems and Control · Electrical Eng. & Systems 2022-06-27 Lorenzo Gentilini , Michelangelo Bin , Lorenzo Marconi

System identification is a common tool for estimating (linear) plant models as a basis for model-based predictive control and optimization. The current challenges in process industry, however, ask for data-driven modelling techniques that…

Systems and Control · Computer Science 2018-02-06 Paul M. J. Van den Hof , Arne G. Dankers , Harm H. M. Weerts

In the UK, approximately 400,000 people with type 1 diabetes (T1D) rely on insulin delivery due to insufficient pancreatic insulin production. Managing blood glucose (BG) levels is crucial, with continuous glucose monitoring (CGM) playing a…

Machine Learning · Computer Science 2023-12-21 Chengzhe Piao , Ken Li

This study explored healthcare professionals' perspectives on the management of Type 1 Diabetes Mellitus (T1DM) through a two-part questionnaire. The first part examined how clinicians prioritise and apply current clinical guidelines,…

Human-Computer Interaction · Computer Science 2026-03-27 Mohammed Basheikh , Rujiravee Kongdee , Hood Thabit , Bijan Parsia , Sarah Clinch , Simon Harper

A novel control design approach for general nonlinear systems is presented in this paper. The approach is based on the identification of a polynomial model of the system to control and on the on-line inversion of this model. An efficient…

Systems and Control · Computer Science 2014-07-07 C. Novara , M. Milanese

Dynamic operation of anaerobic digestion plants requires advanced process monitoring and control. Different simplifications of the Anaerobic Digestion Model No. 1 (ADM1) have been proposed recently, which appear promising for model-based…

Systems and Control · Electrical Eng. & Systems 2023-04-06 Simon Hellmann , Arne-Jens Hempel , Stefan Streif , Sören Weinrich

Automated Insulin Delivery (AID) systems represent a significant advancement in diabetes care and wearable physiological closed-loop control technologies, integrating continuous glucose monitoring, control algorithms, and insulin pumps to…

Cryptography and Security · Computer Science 2026-01-21 Yuchen Niu , Siew-Kei Lam

In control design most control strategies are model-based and require accurate models to be applied successfully. Due to simplifications and the model-reality-gap physics-derived models frequently exhibit deviations from real-world-systems.…

Optimization and Control · Mathematics 2022-08-09 Ricarda-Samantha Götte , Julia Timmermann

Hybrid systems are traditionally difficult to identify and analyze using classical dynamical systems theory. Moreover, recently developed model identification methodologies largely focus on identifying a single set of governing equations…

Dynamical Systems · Mathematics 2019-06-19 Niall M Mangan , Travis Askham , Steven L Brunton , J Nathan Kutz , Joshua L Proctor

Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms are recognized: type 1 diabetes (T1D), which involves autoimmune destruction of…

Genomics · Quantitative Biology 2026-02-11 Maria De La Luz Lomboy Toledo , Daniel Onah

AI procedures joined with wearable gadgets can convey exact transient blood glucose level forecast models. Also, such models can learn customized glucose-insulin elements dependent on the sensor information gathered by observing a few parts…

Machine Learning · Computer Science 2021-01-22 Ignacio Rodriguez

In type 2 diabetes (T2D) treatment, finding a safe and effective basal insulin dose is a challenge. The dose-response is highly individual and to ensure safety, people with T2D titrate by slowly increasing the daily insulin dose to meet…

Systems and Control · Electrical Eng. & Systems 2022-11-28 Sarah Ellinor Engell , Tinna Björk Aradóttir , Tobias K. S. Ritschel , Henrik Bengtsson , John Bagterp Jørgensen

A two-dimensional system of differential equations with delay modelling the glucose-insulin interaction processes in the human body is considered. Sufficient conditions are derived for the unique positive equilibrium in the system to be…

Dynamical Systems · Mathematics 2020-12-11 M. Angelova , G. Beliakov , A. Ivanov , S. Shelyag

This note aims to provide a systematic investigation of direct data-driven control, enriching the existing literature not by adding another isolated result, but rather by offering a unifying, versatile, and broad framework that enables the…

Systems and Control · Electrical Eng. & Systems 2025-08-11 Nima Monshizadeh , Claudio De Persis , Pietro Tesi

Accurately estimating parameters of physiological models is essential to achieving reliable digital twins. For Type 1 Diabetes, this is particularly challenging due to the complexity of glucose-insulin interactions. Traditional methods…

Nonlinear systems play a significant role in numerous scientific and engineering disciplines, and comprehending their behavior is crucial for the development of effective control and prediction strategies. This paper introduces a novel…

Systems and Control · Electrical Eng. & Systems 2023-08-15 Kaushal Kumar

Recent advances in SSL enabled novel medical AI models, known as foundation models, offer great potential for better characterizing health from diverse biomedical data. CGM provides rich, temporal data on glycemic patterns, but its full…

Artificial Intelligence and Machine Learning (AI/ML) models used in clinical settings are increasingly deployed to support clinical decision-making. However, when training data become stale due to changes in demographics, environment, or…

Artificial Intelligence · Computer Science 2026-04-28 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Blood glucose prediction is an important component of biomedical technology for managing diabetes with automated insulin delivery systems. Machine learning and deep learning algorithms hold the potential to advance this technology. However,…

Software Engineering · Computer Science 2024-06-14 Miriam K. Wolff , Sam Royston , Anders Lyngvi Fougner , Hans Georg Schaathun , Martin Steinert , Rune Volden