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Metastases are the primary cause of death in cancer patients. Small animal models are helping in dissecting some of key features in the metastatic cascade. Yet, tools for systematically analyze the contribution of blood flow, vascular…
Thin-plate spline (TPS) is a principal warp that allows for representing elastic, nonlinear transformation with control point motions. With the increase of control points, the warp becomes increasingly flexible but usually encounters a…
We present a new asymptotic strategy for general micro-macro models which analyze complex viscoelastic fluids governed by coupled multiscale dynamics. In such models, the elastic stress appearing in the macroscopic continuum equation is…
There is a growing interest in producing materials with mechanical behaviours similar to those of internal organs. An artificial tissue may be expected to experience several types of compressive and shear deformation in the course of normal…
The motivation of this work is the detection of cerebrovascular accidents by microwave tomographic imaging. This requires the solution of an inverse problem relying on a minimization algorithm (for example, gradient-based), where successive…
Coupling between flows and material properties imbues rheological matter with its wide-ranging applicability, hence the excitement for harnessing the rheology of active fluids for which internal structure and continuous energy injection…
Introduction: Characteristics of hemodynamics strongly affect the patency of arteriovenous fistula (AVF) in hemodialysis patients. Because of pressure balance changes among arteries after AVF construction, regurgitating flow occurs in some…
A chemotaxis-diffusion-convection coupling system for describing a form of buoyant convection in which the fluid develops convection cells and plume patterns will be investigated numerically in this study. Based on the two-dimensional…
Aims: To develop an in-silico model of the aorta and its spinal cord-supplying branches, and to characterise haemodynamic changes following aortic aneurysm (AA) repair with such a model. The work is motivated by the risk of spinal cord…
Direct Numerical Simulations of the injection of a pulsed round liquid jet in a stagnant gas are performed in a series of runs of geometrically progressing resolution. The Reynolds and Weber numbers and the density ratio are sufficiently…
The majority of practical flows, particularly those flows in applications of importance to transport, distribution and climate, are turbulent and as a result experience complex three-dimensional motion with increased drag compared with the…
This paper explores an iterative coupling approach to solve linear thermo-poroelasticity problems, with its application as a high-fidelity discretization utilizing finite elements during the training of projection-based reduced order…
In this work, we present a coupled 3D-1D model of solid tumor growth within a dynamically changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the model includes erosion of the extracellular matrix,…
Ultrasound Localization Microscopy can resolve the microvascular bed down to a few micrometers. To achieve such performance microbubble contrast agents must perfuse the entire microvascular network. Microbubbles are then located…
Pulmonary embolism, the obstruction of a pulmonary artery by a blood clot, is one of the leading causes of acute cardiovascular syndrome. In clinical practice, therapeutic decisions after diagnosis via computed tomography pulmonary…
Generation of super-resolution (SR) ultrasound (US) images, created from the successive local-ization of individual microbubbles in the circulation, has enabled the visualization of microvascular structure and flow at a level of detail that…
Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in…
Joint deconvolution and segmentation of ultrasound images is a challenging problem in medical imaging. By adopting a hierarchical Bayesian model, we propose an accelerated Markov chain Monte Carlo scheme where the tissue reflectivity…
This work develops a computational and theoretical framework for determining effective permeabilities in anisotropic microscopic geometries containing dense, fibre-like obstacles, motivated by the need to model flow in coiled aneurysm…
Many experiments in biomedical applications and other disciplines use a shock tube. These experiments often involve placing an experimental sample within a fluid-filled container, which is then placed inside the shock tube. The shock tube…