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Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…
Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of cancer cells in glucose-poor environments, allowing them to…
We present and critically discuss five commonly used mathematical models of the meal glucose rate of appearance in humans. Such models are key to simulation of the metabolism in healthy people, people with diabetes, and obese people, and…
Traditional models of glucose-insulin dynamics rely on heuristic parameterizations chosen to fit observations within a laboratory setting. However, these models cannot describe glucose dynamics in daily life. One source of failure is in…
It is a well-established fact that tumors up-regulate glucose consumption to meet increasing demands for rapidly available energy by switching to purely glycolytic mode of glucose metabolism. What is often neglected is that cytotoxic cells…
The Glycemic Index (GI) is a tool for classifying carbohydrates based on their impact on postprandial glycemia, useful for diabetes prevention and management. This study applies a mathematical model for a data driven simulation of the…
Diabetes is one of the deadliest diseases in the world and affects nearly 10 percent of the global adult population. Fortunately, powerful new technologies allow for a consistent and reliable treatment plan for people with diabetes. One…
Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is a molecular imaging methodology capable of mapping brain metabolites with relatively high spatial resolution. Specificity is the main goal of such experiments;…
In the U.S., over a third of adults are pre-diabetic, with 80\% unaware of their status. This underlines the need for better glucose monitoring to prevent type 2 diabetes and related heart diseases. Existing wearable glucose monitors are…
Here, we develop a mathematical model for glucose-insulin regulatory system. The model includes a new parameter which is the amount of ingested glucose. Ingested glucose is an external glucose source coming from digested food. We assume…
Continuous glucose monitoring (CGM) data has revolutionized the management of type 1 diabetes, particularly when integrated with insulin pumps to mitigate clinical events such as hypoglycemia. Recently, there has been growing interest in…
It is well known that tumors originating from the same tissue have different prognosis and sensitivity to treatments. Over the last decade, cancer genomics consortia like the Cancer Genome Atlas (TCGA) have been generating thousands of…
Diabetes mellitus is a disease that affects to hundreds of millions of people worldwide. Maintaining a good control of the disease is critical to avoid severe long-term complications. In recent years, several artificial pancreas systems…
Effective dietary monitoring is critical for managing Type 2 diabetes, yet accurately estimating caloric intake remains a major challenge. While continuous glucose monitors (CGMs) offer valuable physiological data, they often fall short in…
A variety of oscillations are observed in pancreatic islets.We establish a model, incorporating two oscillatory systems of different time scales: One is the well-known bursting model in pancreatic beta-cells and the other is the…
Dynamic contrast-enhanced (DCE) MRI is essential for breast cancer diagnosis and treatment. However, its reliance on contrast agents introduces safety concerns, contraindications, increased cost, and workflow complexity. To this end, we…
We utilize dynamical modes as features derived from Continuous Glucose Monitoring (CGM) data to detect meal events. By leveraging the inherent properties of underlying dynamics, these modes capture key aspects of glucose variability,…
Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…
Glucose monitoring plays a critical role in managing diabetes, one of the most prevalent diseases globally. The development of fast-responsive, cost-effective, and biocompatible glucose sensors is essential for improving patient care. In…
The rising rates of diabetes necessitate innovative methods for its management. Continuous glucose monitors (CGM) are small medical devices that measure blood glucose levels at regular intervals providing insights into daily patterns of…