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High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

Transcranial ultrasound imaging is usually limited by skull-induced attenuation and high-order aberrations. By using contrast agents such as microbubbles in combination with ultrafast imaging, not only can the signal-to-noise ratio be…

Imaging the human brain vasculature with high spatial and temporal resolution remains challenging in the clinic today. Transcranial ultrasound is scarcely used for cerebrovascular imaging, due to low sensitivity and strong phase aberrations…

Four-dimensional Flow MRI enables non-invasive, time-resolved imaging of blood flow in three spatial dimensions, offering valuable insights into complex hemodynamics. However, its clinical utility is limited by low spatial resolution and…

Image and Video Processing · Electrical Eng. & Systems 2026-03-17 Aurélien de Turenne , Rémi Cart-Lamy , Denis Kouamé

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on sub-wavelength features is carried by evanescent waves, never reaching the camera,…

Optics · Physics 2018-12-13 Oren Solomon , Yonina C. Eldar , Maor Mutzafi , Mordechai Segev

Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 {\mu}m ~ {\lambda}/10 in the rodent brain.…

Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or…

We present a novel approach to transcranial ultrasound computed tomography that utilizes normalizing flows to improve the speed of imaging and provide Bayesian uncertainty quantification. Our method combines physics-informed methods and…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Rafael Orozco , Mathias Louboutin , Ali Siahkoohi , Gabrio Rizzuti , Tristan van Leeuwen , Felix Herrmann

Super-resolution is widely used in medical imaging to enhance low-quality data, reducing scan time and improving abnormality detection. Conventional super-resolution approaches typically rely on paired datasets of downsampled and original…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Xiaoyi Wen , Fei Jiang

Contrast-enhanced ultrasound (CEUS) presents distinct advantages in diagnostic echography. Utilizing microbubbles (MBs) as conventional contrast agents enhances vascular visualization and organ perfusion, facilitating real-time,…

Medical Physics · Physics 2024-12-04 Agisilaos Matalliotakis , Martin D. Verweij

Super-resolution is an innovative technique that upscales the resolution of an image or a video and thus enables us to reconstruct high-fidelity images from low-resolution data. This study performs super-resolution analysis on turbulent…

Super-resolution ultrasound imaging (SRUS) is an active area of research as it brings up to a ten-fold improvement in the resolution of microvascular structures. The limitations to the clinical adoption of SRUS include long acquisition…

Image and Video Processing · Electrical Eng. & Systems 2024-08-05 Arthur David Redfern , Katherine G. Brown

This paper surveys machine-learning-based super-resolution reconstruction for vortical flows. Super resolution aims to find the high-resolution flow fields from low-resolution data and is generally an approach used in image reconstruction.…

Fluid Dynamics · Physics 2023-07-05 Kai Fukami , Koji Fukagata , Kunihiko Taira

Effective clutter filtering is crucial in suppressing tissue clutter and extracting blood flow signal in Doppler ultrasound. Recent advances in eigen-based clutter filtering techniques have enabled ultrasound imaging of microvasculature…

Medical Physics · Physics 2024-05-21 Chengwu Huang , U-Wai Lok , Jingke Zhang , Hui Liu , Shigao Chen

Segmentation of medical images is a fundamental task with numerous applications. While MRI, CT, and PET modalities have significantly benefited from deep learning segmentation techniques, more recent modalities, like functional ultrasound…

Image and Video Processing · Electrical Eng. & Systems 2025-07-24 Hana Sebia , Thomas Guyet , Mickaël Pereira , Marco Valdebenito , Hugues Berry , Benjamin Vidal

In this methods paper, we explore the capabilities of high-speed ultrasound imaging (USI) to study fast varying and complex multi-phase structures in liquids and soft materials. Specifically, we assess the advantages and the limitations of…

Fluid Dynamics · Physics 2024-01-04 Juan Manuel Rosselló , Saber Izak Ghasemian , Claus-Dieter Ohl

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong

Thanks to its capability of acquiring full-view frames at multiple kilohertz, ultrafast ultrasound imaging unlocked the analysis of rapidly changing physical phenomena in the human body, with pioneering applications such as ultrasensitive…

Image and Video Processing · Electrical Eng. & Systems 2020-12-22 Dimitris Perdios , Manuel Vonlanthen , Florian Martinez , Marcel Arditi , Jean-Philippe Thiran

Transcranial ultrasound imaging is currently limited by attenuation and aberration induced by the skull. First used in contrast-enhanced ultrasound (CEUS), highly echoic microbubbles allowed for the development of novel imaging modalities…

Image and Video Processing · Electrical Eng. & Systems 2025-11-06 Paul Xing , Antoine Malescot , Eric Martineau , Ravi Rungta , Jean Provost

Contrast microbubbles (contrast agents) were initially developed to increase the contrast of the image in ultrasound imaging. These microbubbles consist of a gas core encapsulated by a layer of protein or lipid to stabilize them against…

Medical Physics · Physics 2018-02-26 Nima Mobadersany , Kausik Sarkar