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The transport of bio-particles in viscous flows exhibits a rich variety of dynamical behaviour, such as morphological transitions, complex orientation dynamics or deformations. Characterising such complex behaviour under well controlled…

4D Flow Magnetic Resonance Imaging (4D Flow MRI) is a non-invasive technique for volumetric, time-resolved blood flow quantification. However, apparent trade-offs between acquisition time, image noise, and resolution limit clinical…

Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference…

Computer Vision and Pattern Recognition · Computer Science 2017-08-28 Cagdas Ulas , Christine Preibisch , Jonathan Sperl , Thomas Pyka , Jayashree Kalpathy-Cramer , Bjoern Menze

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Imaging of the optical properties of individual nanosystems beyond fluorescence can provide a wealth of information. However, the minute signals for absorption and dispersion are challenging to observe, and only specialized techniques…

Optics · Physics 2015-09-10 Matthias Mader , Jakob Reichel , Theodor W. Hänsch , David Hunger

Microdialysis is a well-established method for in vivo neurochemical measurements of small molecules, with implanted concentric-design probes offering minimized tissue damage and good temporal and spatial resolution. However, the large…

Quantitative Methods · Quantitative Biology 2021-09-10 Damon Vinciguerra , Margot Vigeant , Ewan C. McNay

Microscopy gives access to spatially resolved dynamics in different systems, from biological cells to cold atoms. A big challenge is maximizing the information per used probe particle to limit the damage to the probed system. We present a…

Multi-contrast images are commonly acquired together to maximize complementary diagnostic information, albeit at the expense of longer scan times. A time-efficient strategy to acquire high-quality multi-contrast images is to accelerate…

An extended aperture has the potential to greatly improve ultrasound imaging performance. This work extends the effective aperture size by coherently compounding the received radio frequency data from multiple transducers. A framework is…

Medical Physics · Physics 2019-11-12 Laura Peralta , Alberto Gomez , Ying Luan , Baehyung Kim , Joseph V. Hajnal , Robert J. Eckersley

High-fidelity, high-resolution numerical simulations are crucial for studying complex multiscale phenomena in fluid dynamics, such as turbulent flows and ocean waves. However, direct numerical simulations with high-resolution solvers are…

Numerical Analysis · Mathematics 2025-04-14 Wuzhe Xu , Yulong Lu , Lian Shen , Anqing Xuan , Ali Barzegari

Spatial transcriptomics provides an unprecedented perspective for deciphering tissue spatial heterogeneity. However, high-resolution spatial transcriptomic technology remains constrained by limited gene coverage, technical complexity, and…

Biomolecules · Quantitative Biology 2026-05-19 Xinlei Huang , Weihao Dai , Zijun Qin , Xin Yu , Di Wang , Yanran Liu , Lixin Cheng , Xubin Zheng

Improved understanding of gas/liquid transport in electrochemical gas-evolving systems is increasingly demanded for optimizing device performance. However, high-resolution measurement techniques for in-situ imaging remain limited. This work…

Major biological discoveries have been made by interrogating living organisms with light. However, the limited penetration of unscattered photons within biological tissues severely limits the depth range covered by optical methods.…

Least-squares reverse time migration is well-known for its capability to generate artifact-free true-amplitude subsurface images through fitting observed data in the least-squares sense. However, when applied to realistic imaging problems,…

Geophysics · Physics 2020-03-04 Mengmeng Yang , Zhilong Fang , Philipp Witte , Felix J. Herrmann

Chemical separations are costly in terms of energy, time, and money. Separation methods are optimized with inefficient trial-and-error approaches that lack insight into the molecular dynamics that lead to the success or failure of a…

Focused transmits are the most commonly used transmit strategy for echocardiograms, but suffer from relatively low frame rates, and in 3D, even lower volume rates. Fast imaging based on unfocused transmits has disadvantages such as motion…

Signal Processing · Electrical Eng. & Systems 2026-05-14 Wessel L. van Nierop , Oisín Nolan , Tristan S. W. Stevens , Ruud J. G. van Sloun

We demonstrate that the permeability of the cell wall of microalga $\textit{C. reinhardtii}$ can be enhanced in controlled microstreaming flow conditions using single bubbles adherent to a wall and driven by ultrasound near their resonance…

Quantitative Methods · Quantitative Biology 2021-12-20 Angelo Pommella , Irina Harun , Klaus Hellgardt , Valeria Garbin

Single molecule localization microscopy (SMLM) techniques enable imaging biological samples well beyond the diffraction limit of light, but they vary significantly in their spatial and temporal resolutions. High-order statistical analysis…

Biological Physics · Physics 2016-03-15 Shachar Schidorsky , Xiyu Yi , Yair Razvag , Yonatan Golan , Shimon Weiss , Eilon Sherman

Dispersion-based photonics-assisted microwave measurement systems provide immense potential for real-time analysis of wideband and dynamic signals. However, they face two critical challenges: a difficulty in achieving high frequency…

Optics · Physics 2026-02-13 Chi Jiang , Taixia Shi , Hang Yang , Lei Gao , Xianxin Zhang , Yiqing Liu , Yang Chen

Spectral imaging enables spatially-resolved identification of materials in remote sensing, biomedicine, and astronomy. However, acquisition times require balancing spectral and spatial resolution with signal-to-noise. Hyperspectral imaging…

Computer Vision and Pattern Recognition · Computer Science 2020-03-17 Nguyen Tran , Rupali Mankar , David Mayerich , Zhu Han
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