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Accurate prediction of drug-target interactions (DTI) is pivotal for drug discovery, yet existing methods often fail to address challenges like cross-domain generalization, cold-start prediction, and interpretability. In this work, we…

Multimedia · Computer Science 2025-10-23 Xiangyu Li , Haojie Yang , Kaimiao Hu , Runzhi Wu , Liangliang Liu , Ran Su

Model identification of battery dynamics is a central problem in energy research; many energy management systems and design processes rely on accurate battery models for efficiency optimization. The standard methodology for battery…

Machine Learning · Computer Science 2023-10-13 Gokhan Budan , Francesca Damiani , Can Kurtulus , N. Kemal Ure

To ensure reliable object detection in autonomous systems, the detector must be able to adapt to changes in appearance caused by environmental factors such as time of day, weather, and seasons. Continually adapting the detector to…

Computer Vision and Pattern Recognition · Computer Science 2023-11-22 Anh-Dzung Doan , Bach Long Nguyen , Surabhi Gupta , Ian Reid , Markus Wagner , Tat-Jun Chin

We derive a new criterion for estimating characteristic dynamical timescales in N-body simulations. The criterion uses the second, third, and fourth derivatives of particle positions: acceleration, jerk, and snap. It can be used for…

Earth and Planetary Astrophysics · Physics 2024-01-09 Dang Pham , Hanno Rein , David S. Spiegel

Discrete stochastic processes are prevalent in natural systems, with applications in physics, biochemistry, epidemiology, sociology, and finance. While analytic solutions often cannot be derived, existing simulation frameworks can generate…

Quantitative Methods · Quantitative Biology 2025-04-03 Aurelien Pelissier , Miroslav Phan , Didier Le Bail , Niko Beerenwinkel , Maria Rodriguez Martinez

Deep Reinforcement Learning has been successfully applied to learn robotic control. However, the corresponding algorithms struggle when applied to problems where the agent is only rewarded after achieving a complex task. In this context,…

Robotics · Computer Science 2023-04-18 Alexandre Chenu , Olivier Serris , Olivier Sigaud , Nicolas Perrin-Gilbert

Demonstrations are commonly used to speed up the learning process of Deep Reinforcement Learning algorithms. To cope with the difficulty of accessing multiple demonstrations, some algorithms have been developed to learn from a single…

Robotics · Computer Science 2024-02-15 Alexandre Chenu , Olivier Serris , Olivier Sigaud , Nicolas Perrin-Gilbert

Recent advances in dynamic treatment regimes (DTRs) facilitate the search for optimal treatments, which are tailored to individuals' specific needs and able to maximize their expected clinical benefits. However, existing algorithms relying…

Machine Learning · Statistics 2024-10-18 Hanwen Ye , Wenzhuo Zhou , Ruoqing Zhu , Annie Qu

Current methods for disaster scene interpretation in remote sensing images (RSIs) mostly focus on isolated tasks such as segmentation, detection, or visual question-answering (VQA). However, current interpretation methods often fail at…

Computer Vision and Pattern Recognition · Computer Science 2024-10-18 Zhuoran Liu , Danpei Zhao , Bo Yuan

The means to obtain the rate constants of a chemical reaction is a fundamental open problem in both science and the industry. Traditional techniques for finding rate constants require either chemical modifications of the reactants or…

Statistics Theory · Mathematics 2019-07-09 Y. Zhang , Z. Yao , P. Forssen , T. Fornstedt

We propose a new method to measure the task-specific accuracy of Retrieval-Augmented Large Language Models (RAG). Evaluation is performed by scoring the RAG on an automatically-generated synthetic exam composed of multiple choice questions…

Computation and Language · Computer Science 2024-05-24 Gauthier Guinet , Behrooz Omidvar-Tehrani , Anoop Deoras , Laurent Callot

Accurate drug-target interaction (DTI) prediction with machine learning models is essential for drug discovery. Such models should also provide a credible representation of their uncertainty, but applying classical marginal conformal…

Machine Learning · Computer Science 2025-05-27 Morteza Rakhshaninejad , Mira Jurgens , Nicolas Dewolf , Willem Waegeman

Deep reinforcement learning (DRL) has shown remarkable success in simulation domains, yet its application in designing robot controllers remains limited, due to its single-task orientation and insufficient adaptability to environmental…

Robotics · Computer Science 2024-09-20 Yu Tang Liu , Nilaksh Singh , Aamir Ahmad

Training a robust policy is critical for policy deployment in real-world systems or dealing with unknown dynamics mismatch in different dynamic systems. Domain Randomization~(DR) is a simple and elegant approach that trains a conservative…

Machine Learning · Computer Science 2023-05-23 Kang Xu , Yan Ma , Wei Li

Decision and control are core functionalities of high-level automated vehicles. Current mainstream methods, such as functionality decomposition and end-to-end reinforcement learning (RL), either suffer high time complexity or poor…

Machine Learning · Computer Science 2021-05-12 Yang Guan , Yangang Ren , Qi Sun , Shengbo Eben Li , Haitong Ma , Jingliang Duan , Yifan Dai , Bo Cheng

Dynamic material handling (DMH) involves the assignment of dynamically arriving material transporting tasks to suitable vehicles in real time for minimising makespan and tardiness. In real-world scenarios, historical task records are…

Neural and Evolutionary Computing · Computer Science 2025-06-23 Chengpeng Hu , Ziming Wang , Bo Yuan , Jialin Liu , Chengqi Zhang , Xin Yao

This paper presents a novel Riemannian conjugate gradient method for the Kohn-Sham energy minimization problem in density functional theory (DFT), with a focus on non-metallic crystal systems. We introduce an energy-adaptive metric that…

Numerical Analysis · Mathematics 2025-03-21 Daniel Peterseim , Jonas Püschel , Tatjana Stykel

This paper presents a deep learning framework that is capable of solving partially observable locomotion tasks based on our novel interpretation of Recurrent Deterministic Policy Gradient (RDPG). We study on bias of sampled error measure…

Artificial Intelligence · Computer Science 2020-02-11 Doo Re Song , Chuanyu Yang , Christopher McGreavy , Zhibin Li

Robotic weed removal in precision agriculture introduces a repetitive heterogeneous task planning (RHTP) challenge for a mobile manipulator. RHTP has two unique characteristics: 1) an observe-first-and-manipulate-later (OFML) temporal…

Robotics · Computer Science 2025-04-08 Shuangyu Xie , Ken Goldberg , Dezhen Song

Autonomous drone navigation in dynamic environments remains a critical challenge, especially when dealing with unpredictable scenarios including fast-moving objects with rapidly changing goal positions. While traditional planners and…