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Understanding current fluctuations is of fundamental importance and paves the way for the development of practical applications. According to the thermodynamic and kinetic uncertainty relations, the precision of currents can be constrained…

Statistical Mechanics · Physics 2022-10-06 Van Tuan Vo , Tan Van Vu , Yoshihiko Hasegawa

Autocatalytic chemical networks play a predominant role in a large number of natural systems such as in metabolic pathways and in ecological networks. Despite recent efforts, the precise impact of thermodynamic constraints on these networks…

Chemical Physics · Physics 2024-06-14 Armand Despons , Yannick de Decker , David Lacoste

We investigate the thermodynamic implications of two control mechanisms of open chemical reaction networks. The first controls the concentrations of the species that are exchanged with the surroundings, while the other controls the exchange…

Statistical Mechanics · Physics 2022-02-22 Francesco Avanzini , Massimiliano Esposito

Switch-like motifs are among the basic building blocks of biochemical networks. A common motif that can serve as an ultrasensitive switch consists of two enzymes acting antagonistically on a substrate, one making and the other removing a…

Molecular Networks · Quantitative Biology 2023-05-31 Jeremy A. Owen , Pranay Talla , John W. Biddle , Jeremy Gunawardena

Living systems are maintained out-of-equilibrium by external driving forces. At stationarity, they exhibit emergent selection phenomena that break equilibrium symmetries and originate from the expansion of the accessible chemical space due…

Statistical Mechanics · Physics 2026-04-01 Shiling Liang , Paolo De Los Rios , Daniel Maria Busiello

In this and a companion paper we outline a general framework for the thermodynamic description of open chemical reaction networks, with special regard to metabolic networks regulating cellular physiology and biochemical functions. We first…

Chemical Physics · Physics 2014-10-22 Matteo Polettini , Massimiliano Esposito

We derive a universal bound on the large-deviation functions of particle currents in coherent conductors. This bound depends only on the mean value of the relevant current and the total rate of entropy production required to maintain a…

Statistical Mechanics · Physics 2025-10-24 Kay Brandner , Keiji Saito

The thermodynamic uncertainty relation is a prominent result in stochastic thermodynamics that provides a bound on the fluctuations of any thermodynamic flux, also known as current, in terms of the average rate of entropy production. Such…

Statistical Mechanics · Physics 2021-12-22 Taylor Wampler , Andre C Barato

We report the first study of a network of connected enzyme-catalyzed reactions, with added chemical and enzymatic processes that incorporate the recently developed biochemical filtering steps into the functioning of this biocatalytic…

Molecular Networks · Quantitative Biology 2013-12-17 Vladimir Privman , Oleksandr Zavalov , Lenka Halamkova , Fiona Moseley , Jan Halamek , Evgeny Katz

We derive a thermodynamic uncertainty relation (TUR) for first-passage times (FPTs) on continuous time Markov chains. The TUR utilizes the entropy production coming from bidirectional transitions, and the net flux coming from unidirectional…

Statistical Mechanics · Physics 2021-08-11 Arnab Pal , Shlomi Reuveni , Saar Rahav

Thermodynamic uncertainty relations yield a lower bound on entropy production in terms of the mean and fluctuations of a current. We derive their general form for systems under arbitrary time-dependent driving from arbitrary initial states…

Statistical Mechanics · Physics 2021-01-12 Timur Koyuk , Udo Seifert

We develop a method for deriving thermodynamic bounds for first-passage problems of currents with two boundaries in Markov chains. Using this method, we derive a thermodynamic bound on the rate of dissipation in terms of the splitting…

Statistical Mechanics · Physics 2025-12-23 Adarsh Raghu , Izaak Neri

For chemical reaction networks described by a master equation, we define energy and entropy on a stochastic trajectory and develop a consistent nonequilibrium thermodynamic description along a single stochastic trajectory of reaction…

Statistical Mechanics · Physics 2009-11-11 Tim Schmiedl , Udo Seifert

We study the fluctuations of generic currents in multi-terminal, multi-channel quantum transport settings. In the quantum regime, these fluctuations and the resulting precision differ strongly depending on whether the device is of fermionic…

Mesoscale and Nanoscale Physics · Physics 2025-04-08 Didrik Palmqvist , Ludovico Tesser , Janine Splettstoesser

Chemical and biological networks can describe a wide variety of processes, from gene regulatory networks to biochemical oscillations. Modeled by chemical master equations, these processes are inherently stochastic, as fluctuations dominate…

Statistical Mechanics · Physics 2025-12-23 Schuyler B. Nicholson , Luis Pedro García-Pintos

We study systems containing electrons and nuclei. Based on the fact that the thermodynamic limit exists for systems with Dirichlet boundary conditions, we prove that the same limit is obtained if one imposes other boundary conditions such…

Mathematical Physics · Physics 2007-05-23 David Hasler , Jan Philip Solovej

We generalize the thermodynamic uncertainty relation, providing an entropic upper bound for average fluxes in time-continuous steady-state systems (Gingrich et al., Phys. Rev. Lett. 116, 120601 (2016)), to time-discrete Markov chains and to…

Statistical Mechanics · Physics 2017-10-11 Karel Proesmans , Christian Van den Broeck

Cells produce RNA and proteins via molecular templating networks. We show that information transmission in such networks is bounded by functions of a simple thermodynamic property of the network, regardless of complexity. Surprisingly,…

Biological Physics · Physics 2025-06-10 Benjamin Qureshi , Jenny M. Poulton , Thomas E. Ouldridge

Current is a characteristic feature of nonequilibrium systems. In stochastic systems, these currents exhibit fluctuations constrained by the rate of dissipation in accordance with the recently discovered thermodynamic uncertainty relation.…

Statistical Mechanics · Physics 2017-10-30 Todd R. Gingrich , Jordan M. Horowitz

I consider the non-equilibrium DC transport of electrons through a quantum system with a thermoelectric response. This system may be any nanostructure or molecule modeled by the nonlinear scattering theory which includes Hartree-like…

Mesoscale and Nanoscale Physics · Physics 2013-03-06 Robert S. Whitney
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