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A novel method to classify human cells is presented in this work based on the transform-domain method on DNA methylation data. DNA methylation profile variations are observed in human cells with the progression of disease stages, and the…

Genomics · Quantitative Biology 2020-01-01 Xueyuan Zhao , Dario Pompili

With recent advancements in the development of artificial intelligence applications using theories and algorithms in machine learning, many accurate models can be created to train and predict on given datasets. With the realization of the…

Machine Learning · Computer Science 2024-03-29 Pei Xi , Lin

Particle identification is one of the core tasks in the data analysis pipeline at the Large Hadron Collider (LHC). Statistically, this entails the identification of rare signal events buried in immense backgrounds that mimic the properties…

Machine Learning · Statistics 2020-01-20 Vidhi Lalchand

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

DNA sequence alignment is important today as it is usually the first step in finding gene mutation, evolutionary similarities, protein structure, drug development and cancer treatment. Covid-19 is one recent example. There are many…

Genomics · Quantitative Biology 2023-06-01 Suchindra , Preetam Nagaraj

Deep learning has become a powerful tool in computational biology, revolutionising the analysis and interpretation of biological data over time. In our article review, we delve into various aspects of deep learning in computational biology.…

Gel electrophoresis, a widely used technique to separate DNA according to their size and weight, generates images that can be analyzed automatically. Manual or semiautomatic image processing presents a bottleneck for further development and…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Naima Kaabouch , Richard R. Schultz , Barry Milavetz , Lata Balakrishnan

Batch Normalization (BN) has been used extensively in deep learning to achieve faster training process and better resulting models. However, whether BN works strongly depends on how the batches are constructed during training and it may not…

Optimization and Control · Mathematics 2018-10-16 Xiangru Lian , Ji Liu

Hybridization events complicate the accurate reconstruction of phylogenies, as they lead to patterns of genetic heritability that are unexpected under traditional, bifurcating models of species trees. This has led to the development of…

Populations and Evolution · Quantitative Biology 2023-11-09 Marianne Bjorner , Erin K. Molloy , Colin N. Dewey , Claudia Solis-Lemus

Predictions using a combination of decision trees are known to be effective in machine learning. Typical ideas for constructing a combination of decision trees for prediction are bagging and boosting. Bagging independently constructs…

Machine Learning · Computer Science 2024-02-12 Keito Tajima , Naoki Ichijo , Yuta Nakahara , Toshiyasu Matsushima

Quantum-classical Hybrid Machine Learning (QHML) models are recognized for their robust performance and high generalization ability even for relatively small datasets. These qualities offer unique advantages for anti-cancer drug response…

Machine Learning · Computer Science 2025-05-16 Takafumi Ito , Lysenko Artem , Tatsuhiko Tsunoda

Metagenomic studies have increasingly utilized sequencing technologies in order to analyze DNA fragments found in environmental samples.One important step in this analysis is the taxonomic classification of the DNA fragments. Conventional…

Genomics · Quantitative Biology 2020-02-11 Andreas Georgiou , Vincent Fortuin , Harun Mustafa , Gunnar Rätsch

Data-efficient image classification is a challenging task that aims to solve image classification using small training data. Neural network-based deep learning methods are effective for image classification, but they typically require…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Ying Bi , Bing Xue , Mengjie Zhang

Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA…

Quantitative Methods · Quantitative Biology 2015-12-10 Iain G. Johnston , Joerg P. Burgstaller , Vitezslav Havlicek , Thomas Kolbe , Thomas Rulicke , Gottfried Brem , Jo Poulton , Nick S. Jones

The state explosion problem and the exponentially computational complexity restrict the further applications of LTL model checking. To this end, this study tries to seek an acceptable approximate solution for LTL model checking by…

Logic in Computer Science · Computer Science 2019-02-19 Weijun Zhu , Jianwei Wang , Yongwen Fan

Batch Normalization (BN) is an important preprocessing step to many deep learning applications. Since it is a data-dependent process, for some homogeneous datasets it is a redundant or even a performance-degrading process. In this paper, we…

Machine Learning · Computer Science 2022-12-01 Wael Alsobhi , Tarik Alafif , Alaa Abdel-Hakim , Weiwei Zong

The gradient boosting machine is a powerful ensemble-based machine learning method for solving regression problems. However, one of the difficulties of its using is a possible discontinuity of the regression function, which arises when…

Machine Learning · Computer Science 2020-06-22 Andrei V. Konstantinov , Lev V. Utkin

Supervised hashing aims to map the original features to compact binary codes that are able to preserve label based similarity in the Hamming space. Non-linear hash functions have demonstrated the advantage over linear ones due to their…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Guosheng Lin , Chunhua Shen , Qinfeng Shi , Anton van den Hengel , David Suter

DNA sequencing to identify genetic variants is becoming increasingly valuable in clinical settings. Assessment of variants in such sequencing data is commonly implemented through Bayesian heuristic algorithms. Machine learning has shown…

Random forest is widely exploited as an ensemble learning method. In many practical applications, however, there is still a significant challenge to learn from imbalanced data. To alleviate this limitation, we propose a deep dynamic boosted…

Machine Learning · Computer Science 2022-03-08 Haixin Wang , Xingzhang Ren , Jinan Sun , Wei Ye , Long Chen , Muzhi Yu , Shikun Zhang