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The twisting and writhing of a cell body and associated mechanical stresses is an underappreciated constraint on microbial self-propulsion. Multi-flagellated bacteria can even buckle and writhe under their own activity as they swim through…

Soft Condensed Matter · Physics 2023-09-25 Wilson Lough , Douglas B. Weibel , Saverio E. Spagnolie

We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix,…

Biological Physics · Physics 2015-06-18 É. Fodor , M. Guo , N. S. Gov , P. Visco , D. A. Weitz , F. van Wijland

Micro-organisms propel themselves in viscous environments by the periodic, nonreciprocal beating of slender appendages known as flagella. Active materials have been widely exploited to mimic this form of locomotion. However, the realization…

Soft Condensed Matter · Physics 2024-08-06 Ariel Surya Boiardi , Giovanni Noselli

Active fluids, such as cytoskeletal filaments, bacterial colonies and epithelial cell layers, exhibit distinctive orientational coherence, often characterized by nematic order and topological defects. By contrast, little is known about…

Soft Condensed Matter · Physics 2021-04-07 Mattia Serra , Linnea Lemma , Luca Giomi , Zvonimir Dogic , L. Mahadevan

Many biological systems are appropriately viewed as passive inclusions immersed in an active bath: from proteins on active membranes to microscopic swimmers confined by boundaries. The non-equilibrium forces exerted by the active bath on…

Soft Condensed Matter · Physics 2020-07-06 Alpha A. Lee , Dominic Vella , John S. Wettlaufer

Recent experiments on the green alga Chlamydomonas that swims using synchronized beating of a pair of flagella have revealed that it exhibits a run-and-tumble behavior similar to that of bacteria such as E. Coli. Using a simple purely…

Cell Behavior · Quantitative Biology 2015-06-12 Rachel R. Bennett , Ramin Golestanian

We present a mathematical model of lophotrichous bacteria, motivated by Pseudomonas putida, which swim through fluid by rotating a cluster of multiple flagella extended from near one pole of the cell body. Although the flagella rotate…

Quantitative Methods · Quantitative Biology 2024-08-26 Jeungeun Park , Yongsam Kim , Wanho Lee , Veronika Pfeifer , Valeriia Muraveva , Carsten Beta , Sookkyung Lim

The intricate wobbling motion of flagellated bacteria, characterized by the periodic precession of the cell body, is a determinant factor in their motility and navigation within complex fluid environments. While well-studied in quiescent…

Soft Condensed Matter · Physics 2026-01-26 Wei Feng , Fanglong Dang , Hao Luo , Alan C. H. Tsang , Yanan Liu , Guangyin Jing

Numerous studies have explored the link between bacterial swimming and the number of flagella, a distinguishing feature of motile multiflagellated bacteria. We revisit this open question using augmented slender-body theory simulations, in…

Biological Physics · Physics 2024-09-04 Maria Tătulea-Codrean , Eric Lauga

Mechanical oscillations are important for many cellular processes, e.g. the beating of cilia and flagella or the sensation of sound by hair cells. These dynamic states originate from spontaneous oscillations of molecular motors. A…

Biological Physics · Physics 2009-01-29 Stefan Gunther , Karsten Kruse

The natural habitats of microorganisms in the human microbiome and ocean and soil ecosystems are full of colloids and macromolecules, which impart non-Newtonian flow properties drastically affecting the locomotion of swimming…

Soft Condensed Matter · Physics 2022-04-01 Shashank Kamdar , Seunghwan Shin , Lorraine F. Francis , Xinliang Xu , Xiang Cheng

This paper focuses on studying a model for molecular motors responsible for the bending of the axoneme in the flagella of microorganisms. The model is a coupled system of partial differential equations inspired by J\"ulicher et al. or…

Numerical Analysis · Mathematics 2025-04-17 François Alouges , Irene Anello , Antonio DeSimone , Aline Lefebvre-Lepot , Jessie Levillain

Peritrichous bacteria synchronize and bundle their flagella to actively swim while disruption of the bundle leads to tumbling. It is still not known whether the number of flagella represents an evolutionary adaptation towards optimizing…

Biological Physics · Physics 2020-04-21 Javad Najafi , M. Reza Shaebani , Thomas John , Florian Altegoer , Gert Bange , Christian Wagner

The basic phenomenology of experimentally observed synchronization (i.e., a stochastic phase locking) of identical, beating flagella of a biflagellate alga is known to be captured well by a minimal model describing the dynamics of coupled,…

Soft Condensed Matter · Physics 2019-02-28 V. Dotsenko , A. Maciolek , G. Oshanin , O. A. Vasilyev , S. Dietrich

Active phenomena which involve force generation and motion play a key role in a number of phenomena in living cells such as cell motility, muscle contraction and the active transport of material and organelles. Here we discuss mechanical…

Biological Physics · Physics 2007-05-23 Frank Julicher

Propelling microorganisms through fluids and moving fluids along cellular surfaces are essential biological functions accomplished by long, thin structures called motile cilia and flagella, whose regular, oscillatory beating breaks the…

The flexibility of the bacterial flagellar hook is believed to have substantial consequences for microorganism locomotion. Using a simplified model of a rigid flagellum and a flexible hook, we show that the paths of axisymmetric cell bodies…

Biological Physics · Physics 2021-10-28 Zonghao Zou , Wilson Lough , Saverio E. Spagnolie

Many biological microswimmers can modulate their swimming gait to achieve directional control of motility, especially when performing steering towards specific directional cues. This can be achieved without the need for obvious…

Micro-organisms usually can swim in their liquid environment by flagellar or ciliary beating. In this numerical work, we analyze the influence of flagellar beating on the orbits of a swimming cell in a shear flow. We also calculate the…

Soft Condensed Matter · Physics 2017-11-21 Levan Jibuti , Walter Zimmermann , Salima Rafaï , Philippe Peyla

Effective organismal behavior responds appropriately to changes in the surrounding environment. Attaining this delicate balance of sensitivity and stability is a hallmark of the animal kingdom. By studying the locomotory behavior of a…

Biological Physics · Physics 2021-07-08 Matthew S. Bull , Vivek N. Prakash , Manu Prakash