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Precise identification of mouse brain microscopy images is a crucial first step when anatomical structures in the mouse brain are to be registered to a reference atlas. Practitioners usually rely on manual comparison of images or tools that…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Justinas Antanavicius , Roberto Leiras , Raghavendra Selvan

Magnetic Resonance Imaging (MRI) of the fetal brain has become a key tool for studying brain development in vivo. Yet, its assessment remains challenging due to variability in brain maturation, imaging protocols, and uncertain estimates of…

Image and Video Processing · Electrical Eng. & Systems 2025-10-09 Johannes Tischer , Patric Kienast , Marlene Stümpflen , Gregor Kasprian , Georg Langs , Roxane Licandro

This paper presents a variational framework for dense diffeomorphic atlas-mapping onto high-throughput histology stacks at the 20 um meso-scale. The observed sections are modelled as Gaussian random fields conditioned on a sequence of…

Image and Video Processing · Electrical Eng. & Systems 2019-03-06 Brian C. Lee , Daniel J. Tward , Partha P. Mitra , Michael I. Miller

Over the last ten years, developments in whole-brain microscopy now allow for high-resolution imaging of intact brains of small rodents such as mice. These complex images contain a wealth of information, but many neuroscience laboratories…

Neurons and Cognition · Quantitative Biology 2021-02-24 Adam L Tyson , Troy W Margrie

Accurate brain lesion delineation is important for planning neurosurgical treatment. Automatic brain lesion segmentation methods based on convolutional neural networks have demonstrated remarkable performance. However, neural network…

Image and Video Processing · Electrical Eng. & Systems 2024-08-20 Jiayu Huo , Sebastien Ourselin , Rachel Sparks

In this paper, we introduce a novel structural holistic Atlas (holiAtlas) of the human brain anatomy based on multimodal and high-resolution MRI that covers several anatomical levels from the organ to the substructure level, using a new…

Registration is a core component of many imaging pipelines. In case of clinical scans, with lower resolution and sometimes substantial motion artifacts, registration can produce poor results. Visual assessment of registration quality in…

Segmentation and spatial alignment of ultrasound (US) imaging data acquired in the in first trimester are crucial for monitoring human embryonic growth and development throughout this crucial period of life. Current approaches are either…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 W. A. P. Bastiaansen , M. Rousian , R. P. M. Steegers-Theunissen , W. J. Niessen , A. H. J. Koning , S. Klein

We present a novel neural network architecture called AutoAtlas for fully unsupervised partitioning and representation learning of 3D brain Magnetic Resonance Imaging (MRI) volumes. AutoAtlas consists of two neural network components: one…

Image and Video Processing · Electrical Eng. & Systems 2021-11-12 K. Aditya Mohan , Alan D. Kaplan

We present two techniques to improve landmark localization in images from partially annotated datasets. Our primary goal is to leverage the common situation where precise landmark locations are only provided for a small data subset, but…

Computer Vision and Pattern Recognition · Computer Science 2018-10-30 Sina Honari , Pavlo Molchanov , Stephen Tyree , Pascal Vincent , Christopher Pal , Jan Kautz

Anatomical landmarks are a crucial prerequisite for many medical imaging tasks. Usually, the set of landmarks for a given task is predefined by experts. The landmark locations for a given image are then annotated manually or via machine…

Computer Vision and Pattern Recognition · Computer Science 2020-01-23 Richard Droste , Pierre Chatelain , Lior Drukker , Harshita Sharma , Aris T. Papageorghiou , J. Alison Noble

Automatic and accurate detection of anatomical landmarks is an essential operation in medical image analysis with a multitude of applications. Recent deep learning methods have improved results by directly encoding the appearance of the…

Computer Vision and Pattern Recognition · Computer Science 2021-05-20 Guang-Quan Zhou , Juzheng Miao , Xin Yang , Rui Li , En-Ze Huo , Wenlong Shi , Yuhao Huang , Jikuan Qian , Chaoyu Chen , Dong Ni

Anatomical landmark correspondences in medical images can provide additional guidance information for the alignment of two images, which, in turn, is crucial for many medical applications. However, manual landmark annotation is…

Computer Vision and Pattern Recognition · Computer Science 2020-04-09 Monika Grewal , Timo M. Deist , Jan Wiersma , Peter A. N. Bosman , Tanja Alderliesten

Multi-atlas segmentation is a widely used tool in medical image analysis, providing robust and accurate results by learning from annotated atlas datasets. However, the availability of fully annotated atlas images for training is limited due…

Computer Vision and Pattern Recognition · Computer Science 2016-05-03 Lisa M. Koch , Martin Rajchl , Wenjia Bai , Christian F. Baumgartner , Tong Tong , Jonathan Passerat-Palmbach , Paul Aljabar , Daniel Rueckert

Microscopic analysis of histological sections is considered the "gold standard" to verify structural parcellations in the human brain. Its high resolution allows the study of laminar and columnar patterns of cell distributions, which build…

Computer Vision and Pattern Recognition · Computer Science 2017-08-01 Hannah Spitzer , Katrin Amunts , Stefan Harmeling , Timo Dickscheid

Purpose: Semantic segmentation and landmark detection are fundamental tasks of medical image processing, facilitating further analysis of anatomical objects. Although deep learning-based pixel-wise classification has set a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Ron Keuth , Lasse Hansen , Maren Balks , Ronja Jäger , Anne-Nele Schröder , Ludger Tüshaus , Mattias Heinrich

Deformable templates, or atlases, are images that represent a prototypical anatomy for a population, and are often enhanced with probabilistic anatomical label maps. They are commonly used in medical image analysis for population studies…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Marianne Rakic , Andrew Hoopes , S. Mazdak Abulnaga , Mert R. Sabuncu , John V. Guttag , Adrian V. Dalca

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of…

Computer Vision and Pattern Recognition · Computer Science 2021-11-16 Riddhish Bhalodia , Shireen Elhabian , Ladislav Kavan , Ross Whitaker

Three-dimensional facial stereophotogrammetry provides a detailed representation of craniofacial soft tissue without the use of ionizing radiation. While manual annotation of landmarks serves as the current gold standard for cephalometric…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Bo Berends , Freek Bielevelt , Ruud Schreurs , Shankeeth Vinayahalingam , Thomas Maal , Guido de Jong

Image landmark detection aims to automatically identify the locations of predefined fiducial points. Despite recent success in this field, higher-ordered structural modeling to capture implicit or explicit relationships among anatomical…

Computer Vision and Pattern Recognition · Computer Science 2020-12-09 Weijian Li , Yuhang Lu , Kang Zheng , Haofu Liao , Chihung Lin , Jiebo Luo , Chi-Tung Cheng , Jing Xiao , Le Lu , Chang-Fu Kuo , Shun Miao