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This paper describes a novel approach to medical diagnosis based on the SP theory of computing and cognition. The main attractions of this approach are: a format for representing diseases that is simple and intuitive; an ability to cope…

Artificial Intelligence · Computer Science 2014-09-30 J. Gerard Wolff

Generalization methods offer a powerful solution to one of the key drawbacks of randomized controlled trials (RCTs): their limited representativeness. By enabling the transport of treatment effect estimates to target populations subject to…

Methodology · Statistics 2025-05-20 Ahmed Boughdiri , Clément Berenfeld , Julie Josse , Erwan Scornet

Among many efforts to facilitate timely access to safe and effective medicines to children, increased attention has been given to extrapolation. Loosely, it is the leveraging of conclusions or available data from adults or older age groups…

Methodology · Statistics 2022-10-06 Margaret Gamalo , Yoonji Kim , Fan Zhang , Junjing Lin

A simple and common type of medical research involves the comparison of one treatment against another. The logical aim should be both to establish which treatment is superior and the strength of evidence supporting this conclusion, a task…

Methodology · Statistics 2022-12-08 Nicholas Adams

Extracting information from functional magnetic resonance (fMRI) images has been a major area of research for more than two decades. The goal of this work is to present a new method for the analysis of fMRI data sets, that is capable to…

Based on a weighted knowledge graph to represent first-order knowledge and combining it with a probabilistic model, we propose a methodology for the creation of a medical knowledge network (MKN) in medical diagnosis. When a set of symptoms…

Artificial Intelligence · Computer Science 2017-03-29 Jingchi Jiang , Chao Zhao , Yi Guan , Qiubin Yu

Increasingly complex generative models are being used across disciplines as they allow for realistic characterization of data, but a common difficulty with them is the prohibitively large computational cost to evaluate the likelihood…

Computation · Statistics 2017-03-06 Michael U. Gutmann , Ritabrata Dutta , Samuel Kaski , Jukka Corander

We study the problem of multiple hypothesis testing for multidimensional data when inter-correlations are present. The problem of multiple comparisons is common in many applications. When the data is multivariate and correlated, existing…

Statistics Theory · Mathematics 2015-06-02 Mahdis Azadbakhsh , Xin Gao , Hanna Jankowski

With medical tests becoming increasingly available, concerns about over-testing and over-treatment dramatically increase. Hence, it is important to understand the influence of testing on treatment selection in general practice. Most…

Methodology · Statistics 2020-08-11 Yun Li , Irina Bondarenko , Michael R. Elliott , Timothy P. Hofer , Jeremy M. G. Taylor

The likelihood function represents statistical evidence in the context of data and a probability model. Considerable theory has demonstrated that evidence strength for different parameter values can be interpreted from the ratio of…

Applications · Statistics 2016-11-17 Zeynep Baskurt , Lisa Strug

When estimating causal effects using observational data, it is desirable to replicate a randomized experiment as closely as possible by obtaining treated and control groups with similar covariate distributions. This goal can often be…

Methodology · Statistics 2010-10-28 Elizabeth A. Stuart

There is a growing proportion of people with several disease conditions ("multimorbidity"), placing increasing demands on healthcare systems. One hypothesis is that clusters of diseases may arise from shared underlying disease processes…

Methodology · Statistics 2025-08-15 Anthony J. Webster

Medical automatic diagnosis aims to imitate human doctors in real-world diagnostic processes and to achieve accurate diagnoses by interacting with the patients. The task is formulated as a sequential decision-making problem with a series of…

Machine Learning · Computer Science 2022-06-07 Hongyi Yuan , Sheng Yu

The increasing access to brain signal data using electroencephalography creates new opportunities to study electrophysiological brain activity and perform ambulatory diagnoses of neuronal diseases. This work proposes a pairwise distance…

Machine Learning · Computer Science 2019-09-09 David Calhas , Enrique Romero , Rui Henriques

In spite of years of research, the mechanisms that underlie the development of schizophrenia, as well as its relapse, symptomatology, and treatment, continue to be a mystery. The absence of appropriate analytic tools to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Vigneshwaran Shankaran , Bhaskaran V

Electronic Health Records maintained in health care settings are a potential source of substantial clinical knowledge. The massive volume of data, unstructured nature of records and obligatory requirement of domain acquaintance together…

Information Retrieval · Computer Science 2015-10-13 Gargi Priyadarshini , Ashish Anand

For many interesting tasks, such as medical diagnosis and web page classification, a learner only has access to some positively labeled examples and many unlabeled examples. Learning from this type of data requires making assumptions about…

Machine Learning · Computer Science 2018-08-28 Jessa Bekker , Jesse Davis

Despite the impressive advances achieved using deep learning for functional brain activity analysis, the heterogeneity of functional patterns and the scarcity of imaging data still pose challenges in tasks such as identifying neurological…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Wenhui Cui , Haleh Akrami , Anand A. Joshi , Richard M. Leahy

Composite likelihood inference has gained much popularity thanks to its computational manageability and its theoretical properties. Unfortunately, performing composite likelihood ratio tests is inconvenient because of their awkward…

Computation · Statistics 2014-08-01 Manuela Cattelan , Nicola Sartori

Multiple imputation (MI) inference handles missing data by imputing the missing values $m$ times, and then combining the results from the $m$ complete-data analyses. However, the existing method for combining likelihood ratio tests (LRTs)…

Statistics Theory · Mathematics 2022-01-03 Kin Wai Chan , Xiao-Li Meng