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We investigate the oscillatory dynamics and bifurcation structure of a reaction-diffusion system with bistable nonlinearity and mass conservation, which was proposed by [Otsuji et al, PLoS Comp. Biol. 3 (2007), e108]. The system is a useful…

Cell Behavior · Quantitative Biology 2025-05-23 Masataka Kuwamura , Hirofumi Izuhara , Shin-ichiro Ei

We study a nonlinear PDE problem motivated by the peculiar patterns arising in myxobacteria, namely counter-migrating cell density waves. We rigorously prove the existence of Hopf bifurcations for some specific values of the parameters of…

Analysis of PDEs · Mathematics 2018-07-25 Narek Hovsepyan , Juan J. L. Velázquez

We present an analytical description for the collective dynamics of oscillator ensembles with higher-order coupling encoded by simplicial structure, which serves as an illustrative and insightful paradigm for brain function and information…

Adaptation and Self-Organizing Systems · Physics 2020-07-01 Can Xu , Xuebin Wang , Per Sebastian Skardal

Propagating spiral waves have been discovered in various chemical, biological and physical systems. Spiral waves in multicellular organisms are often associated with essential living functions. Although certain eukaryotic microorganisms…

Biological Physics · Physics 2024-06-04 Shiqi Liu , Ye Li , Yuhao Wang , Yilin Wu

We study the macroscopic dynamics of large networks of excitable type 1 neurons composed of two populations interacting with disparate but symmetric intra- and inter-population coupling strengths. This nonuniform coupling scheme facilitates…

Adaptation and Self-Organizing Systems · Physics 2021-03-17 Benjamin Jüttner , Christian Henriksen , Erik A. Martens

The effect of a temporal modulation at three times the critical frequency on a Hopf bifurcation is studied in the framework of amplitude equations. We consider a complex Ginzburg-Landau equation with an extra quadratic term, resulting from…

Pattern Formation and Solitons · Physics 2009-11-07 Rafael Gallego , Daniel Walgraef , Maxi San Miguel , Raul Toral

Biochemical oscillations are ubiquitous in nature and allow organisms to properly time their biological functions. In this paper, we consider minimal Markov state models of nonequilibrium biochemical networks that support oscillations. We…

Statistical Mechanics · Physics 2020-02-04 Clara del Junco , Suriyanarayanan Vaikuntanathan

Many types of mammalian cells exert active contractile forces and mechanically deform their elastic substrate, to accomplish biological functions such as cell migration. These substrate deformations provide a mechanism by which cells can…

Soft Condensed Matter · Physics 2022-02-22 Subhaya Bose , Patrick S. Noerr , Ajay Gopinathan , Arvind Gopinath , Kinjal Dasbiswas

We introduce two time-delay models of metabolic oscillations in yeast cells. Our model tests a hypothesis that the oscillations occur as multiple pathways share a limited resource which we equate to the number of available ribosomes. We…

Dynamical Systems · Mathematics 2023-12-07 Max M. Chumley , Firas A. Khasawneh , Andreas Otto , Tomas Gedeon

Complex dynamical systems may exhibit multiple steady states, including time-periodic limit cycles, where the final trajectory depends on initial conditions. With tuning of parameters, limit cycles can proliferate or merge at an exceptional…

Statistical Mechanics · Physics 2024-12-03 Sergei Shmakov , Peter B. Littlewood

A theoretical analysis is presented to show the general occurrence of phase clusters in weakly, globally coupled oscillators close to a Hopf bifurcation. Through a reductive perturbation method, we derive the amplitude equation with a…

Adaptation and Self-Organizing Systems · Physics 2014-09-17 Hiroshi Kori , Yoshiki Kuramoto , Swati Jain , István Z. Kiss , John Hudson

How systems are endowed with migration capacity is a fascinating question with implications ranging from the design of novel active systems to the control of microbial populations. Bacteria, which can be found in a variety of environments,…

Biological Physics · Physics 2017-07-03 Marc Hennes , Julien Tailleur , Gaëlle Charron , Adrian Daerr

It has been shown that self-assembled chains of active colloidal particles can present sustained oscillations. These oscillations are possible because of the effective diffusiophoretic forces that mediate the interactions of colloids do not…

Soft Condensed Matter · Physics 2018-03-23 S. Gonzalez , R. Soto

We investigate a diffusive, stage-structured epidemic model with the maturation delay and freely-moving delay. Choosing delays and diffusive rates as bifurcation parameters, the only possible way to destabilize the endemic equilibrium is…

Dynamical Systems · Mathematics 2018-05-25 Yanfei Du , Ben Niu , Junjie Wei

A density oscillator exhibits limit-cycle oscillations driven by the density difference of the two fluids. We performed two-dimensional hydrodynamic simulations with a simple model, and reproduced the oscillatory flow observed in…

Pattern Formation and Solitons · Physics 2020-05-11 Nana Takeda , Naoko Kurata , Hiroaki Ito , Hiroyuki Kitahata

Astounding properties of biological sensors can often be mapped onto a dynamical system in the vicinity a bifurcation. For mammalian hearing, a Hopf bifurcation description has been shown to work across a whole range of scales, from…

Neurons and Cognition · Quantitative Biology 2015-10-13 Florian Gomez , Tom Lorimer , Ruedi Stoop

Oscillatory systems with time-delayed pulsatile feedback appear in various applied and theoretical research areas, and received a growing interest in the last years. For such systems, we report a remarkable scenario of destabilization of a…

Chaotic Dynamics · Physics 2015-05-28 Vladimir Klinshov , Leonhard Lücken , Dmitry Shchapin , Vladimir Nekorkin , Serhiy Yanchuk

Positive feedback and cooperativity in the regulation of gene expression are generally considered to be necessary for obtaining bistable expression states. Recently, a novel mechanism of bistability termed emergent bistability has been…

Quantitative Methods · Quantitative Biology 2012-10-22 Sayantari Ghosh , Subhasis Banerjee , Indrani Bose

The dynamics of an ensemble of bistable elements with global time-delayed coupling under the influence of noise is studied analytically and numerically. Depending on the noise level the system undergoes ordering transitions and demonstrates…

Statistical Mechanics · Physics 2009-11-10 D. Huber , L. S. Tsimring

Multistability is an inseparable feature of many physical, chemical and biological systems which are driven far from equilibrium. In these nonequilibrium systems, stochastic dynamics often induces switching between distinct states on…

Adaptation and Self-Organizing Systems · Physics 2017-11-01 Guram Gogia , Justin Burton