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OCTA is a crucial non-invasive imaging technique for diagnosing and monitoring retinal diseases like diabetic retinopathy, age-related macular degeneration, and glaucoma. Current 2D-based methods for retinal vessel (RV) segmentation offer…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Chuang Liu , Nan Guo

We aim to enhance ophthalmologists' decision-making when diagnosing the Neovascular Age-Related Macular Degeneration (nAMD). We developed three tools to analyze Optical Coherence Tomography Angiography images: (1) extracting biomarkers such…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 MAria Simona Tivadar , Ioana Damian , Adrian Groza , Simona Delia Nicoara

Optical Coherence Tomography (OCT) is an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. Due to the underlying physics, OCT images usually suffer from a granular…

Computer Vision and Pattern Recognition · Computer Science 2015-02-10 Ahmadreza Baghaie , Roshan M. D'souza , Zeyun Yu

Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, each presenting unique benefits and limitations. In-vivo OCT offers rapid, non-invasive imaging but can be hampered by clarity issues and motion…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Xin Tian , Nantheera Anantrasirichai , Lindsay Nicholson , Alin Achim

Medical image segmentation is an important task for computer aided diagnosis. Pixelwise manual annotations of large datasets require high expertise and is time consuming. Conventional data augmentations have limited benefit by not fully…

Image and Video Processing · Electrical Eng. & Systems 2020-04-28 Dwarikanath Mahapatra , Behzad Bozorgtabar , Jean-Philippe Thiran , Ling Shao

Optical coherence tomography (OCT) is a non-invasive imaging technique that can produce images of the eye at the microscopic level. OCT image segmentation to localise retinal layer boundaries is a fundamental procedure for diagnosing and…

Computer Vision and Pattern Recognition · Computer Science 2016-09-09 Jinming Duan , Christopher Tench , Irene Gottlob , Frank Proudlock , Li Bai

Cardiovascular diseases (CVD) are the leading cause of death globally. Non-invasive, cost-effective imaging techniques play a crucial role in early detection and prevention of CVD. Optical coherence tomography (OCT) has gained recognition…

Image and Video Processing · Electrical Eng. & Systems 2025-01-08 Cynthia Maldonado-Garcia , Rodrigo Bonazzola , Enzo Ferrante , Thomas H Julian , Panagiotis I Sergouniotis , Nishant Ravikumara , Alejandro F Frangi

Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging technique that allows visualizations of vasculature and foveal avascular zone (FAZ) across retinal layers. Clinical researches suggest that the morphology and…

Image and Video Processing · Electrical Eng. & Systems 2021-07-14 Li Lin , Zhonghua Wang , Jiewei Wu , Yijin Huang , Junyan Lyu , Pujin Cheng , Jiong Wu , Xiaoying Tang

The development of artificial intelligence models for macular edema (ME) analy-sis always relies on expert-annotated pixel-level image datasets which are expen-sive to collect prospectively. While anomaly-detection-based weakly-supervised…

Image and Video Processing · Electrical Eng. & Systems 2025-08-27 Yuhui Tao , Yizhe Zhang , Qiang Chen

Optical Coherence Tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high…

Medical Physics · Physics 2020-05-29 Cerine Lal , Sergey Alexandrov , Sweta Rani , Yi Zhou , Thomas Ritter , Martin Leahy

Purpose: To assess whether a generative adversarial network (GAN) could synthesize realistic optical coherence tomography (OCT) images that satisfactorily serve as the educational images for retinal specialists and the training datasets for…

Medical Physics · Physics 2020-06-02 Ce Zheng , Xiaolin Xie , Kang Zhou , Bang Chen , Jili Chen , Haiyun Ye , Wen Li , Tong Qiao , Shenghua Gao , Jianlong Yang , Jiang Liu

Optical coherence tomography (OCT) is a high-resolution three-dimensional imaging technique that enables non-destructive measurements of surface and subsurface microstructures. Recent developments of OCT operating in the mid-infrared (MIR)…

Optics · Physics 2020-07-15 Ivan Zorin , Rong Su , Bettina Heise , Bernhard Lendl , Markus Brandstetter

Purpose. Localizing structures and estimating the motion of a specific target region are common problems for navigation during surgical interventions. Optical coherence tomography (OCT) is an imaging modality with a high spatial and…

Image and Video Processing · Electrical Eng. & Systems 2020-04-22 Marcel Bengs , Nils Gessert , Matthias Schlüter , Alexander Schlaefer

Cerebrovascular disease often requires multiple imaging modalities for accurate diagnosis, treatment, and monitoring. Computed Tomography Angiography (CTA) and Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) are two common…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Alexander Koch , Orhun Utku Aydin , Adam Hilbert , Jana Rieger , Satoru Tanioka , Fujimaro Ishida , Dietmar Frey

Stroke is a major public health problem, affecting millions worldwide. Deep learning has recently demonstrated promise for enhancing the diagnosis and risk prediction of stroke. However, existing methods rely on costly medical imaging…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Saeed Shurrab , Aadim Nepal , Terrence J. Lee-St. John , Nicola G. Ghazi , Bartlomiej Piechowski-Jozwiak , Farah E. Shamout

One native source of quality deterioration in medical imaging, and especially in our case optical coherence tomography (OCT), is the turbid biological media in which photon does not take a predictable path and many scattering events would…

Image and Video Processing · Electrical Eng. & Systems 2020-11-26 Ali Alavi

The increasing prevalence of retinal diseases poses a significant challenge to the healthcare system, as the demand for ophthalmologists surpasses the available workforce. This imbalance creates a bottleneck in diagnosis and treatment,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-17 Jia-Hong Huang

Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is…

Segmentation of indicated targets aids in the precise analysis of optical coherence tomography angiography (OCTA) samples. Existing segmentation methods typically perform on 2D projection targets, making it challenging to capture the…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Xinrun Chen , Chengliang Wang , Haojian Ning , Mengzhan Zhang , Mei Shen , Shiying Li

In ophthalmological imaging, multiple imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography, are often involved to make a diagnosis of retinal disease. Multi-modal…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Aline Sindel , Bettina Hohberger , Andreas Maier , Vincent Christlein