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Optical coherence tomography (OCT) has revolutionized retinal disease diagnosis with its high-resolution and three-dimensional imaging nature, yet its full diagnostic automation in clinical practices remains constrained by multi-stage…

Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, offering distinct advantages and limitations. In vivo OCT offers rapid, non-invasive imaging but can suffer from clarity issues and motion artifacts,…

Image and Video Processing · Electrical Eng. & Systems 2024-12-18 Xin Tian , Nantheera Anantrasirichai , Lindsay Nicholson , Alin Achim

Optical coherence tomography (OCT), a commonly used retinal imaging modality, plays a central role in retinal disease diagnosis by providing high-resolution visualization of retinal layers. While deep learning (DL) has achieved expert-level…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Tienyu Chang , Tianhao Li , Ruogu Fang , Jiang Bian , Yu Huang

Diagnosing different retinal diseases from Spectral Domain Optical Coherence Tomography (SD-OCT) images is a challenging task. Different automated approaches such as image processing, machine learning and deep learning algorithms have been…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Sharif Amit Kamran , Sourajit Saha , Ali Shihab Sabbir , Alireza Tavakkoli

Ultra-wide optical coherence tomography angiography (UW-OCTA) is an emerging imaging technique that offers significant advantages over traditional OCTA by providing an exceptionally wide scanning range of up to 24 x 20 $mm^{2}$, covering…

Image and Video Processing · Electrical Eng. & Systems 2023-11-20 Hao Wei , Peilun Shi , Guitao Bai , Minqing Zhang , Shuangle Li , Wu Yuan

Training deep learning models for corneal optical coherence tomography (OCT) imaging is limited by the availability of large, well-annotated datasets. We present a configurable Monte Carlo simulation framework that generates synthetic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-04 Jinglun Yu , Yaning Wang , Rosalinda Xiong , Ziyi Huang , Kristina Irsch , Jin U. Kang

Optical coherence tomography angiography (OCTA) provides non-invasive visualization of retinal microvasculature, but learning robust representations remains challenging due to sparse vessel structures and strong topological constraints.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Ilerioluwakiiye Abolade , Prince Mireku , Kelechi Chibundu , Peace Ododo , Emmanuel Idoko , Promise Omoigui , Solomon Odelola

Recent advancements in medical image analysis have led to the development of highly specialized models tailored to specific clinical tasks. These models have demonstrated exceptional performance and remain a crucial research direction. Yet,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-19 Alessio Negrini , Simon Reiß

Quantification of intra-retinal boundaries in optical coherence tomography (OCT) is a crucial task for studying and diagnosing neurological and ocular diseases. Since manual segmentation of layers is usually a time consuming task and relay…

Computer Vision and Pattern Recognition · Computer Science 2015-02-17 Mahdi Salarian

Optical coherence tomography angiography (OCTA) requires high transverse sampling density for visualizing retinal and choroidal capillaries. Low transverse sampling causes resolution degradation, such as the angiograms in wide-field OCTA.…

Image and Video Processing · Electrical Eng. & Systems 2020-01-09 Ting Zhou , Kang Zhou , Jianlong Yang , Liyang Fang , Yan Hu , Yitian Zhao , Jun Cheng , Xiangping Chen , Shenghua Gao , Jiang Liu

In the world of medical diagnostics, the adoption of various deep learning techniques is quite common as well as effective, and its statement is equally true when it comes to implementing it into the retina Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Tasnim Sakib Apon , Mohammad Mahmudul Hasan , Abrar Islam , MD. Golam Rabiul Alam

To develop a new method to quantify nonperfused retinal capillaries (NPCs) by using co-registered optical coherence tomography (OCT) and OCT angiography (OCTA), and to evaluate NPCs in eyes with age-related macular degeneration (AMD) and…

Quantitative Methods · Quantitative Biology 2024-11-11 Min Gao , Yukun Guo , Tristan T. Hormel , Jie Wang , Elizabeth White , Dong-Wouk Park , Thomas S. Hwang , Steven T. Bailey , Yali Jia

Optical Coherence Tomography (OCT) is an imaging modality that has been widely adopted for visualizing corneal, retinal and limbal tissue structure with micron resolution. It can be used to diagnose pathological conditions of the eye, and…

Image and Video Processing · Electrical Eng. & Systems 2019-05-08 Jiahong Ouyang , Tejas Sudharshan Mathai , Kira Lathrop , John Galeotti

The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. Current image processing methods are hindered by the time…

Machine Learning · Computer Science 2021-04-20 Arjun Balaji , Lachlan Kelsey , Kamran Majeed , Carl Schultz , Barry Doyle

Many eye diseases like Diabetic Macular Edema (DME), Age-related Macular Degeneration (AMD), and Glaucoma manifest in the retina, can cause irreversible blindness or severely impair the central version. The Optical Coherence Tomography…

Image and Video Processing · Electrical Eng. & Systems 2023-03-10 Nchongmaje Ndipenoch , Alina Miron , Zidong Wang , Yongmin Li

According to the World Health Organization, 285 million people worldwide live with visual impairment. The most commonly used imaging technique for diagnosis in ophthalmology is optical coherence tomography (OCT). However, analysis of…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Max-Heinrich Laves , Sontje Ihler , Lüder A. Kahrs , Tobias Ortmaier

Geographic atrophy (GA) is a key biomarker of dry age-related macular degeneration (AMD) traditionally identified through color fundus photography. Hyper-transmission defects (hyperTDs), a feature highly correlated with GA, have recently…

Quantitative Methods · Quantitative Biology 2025-11-04 Yukun Guo , An-Lun Wu , Tristan T. Hormel , Liqin Gao , Min Gao , Thomas S. Hwang , Steven T. Bailey , Yali Jia

Segmentation of blood vessels in murine cerebral 3D OCTA images is foundational for in vivo quantitative analysis of the effects of neurovascular disorders, such as stroke or Alzheimer's, on the vascular network. However, to accurately…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Bastian Wittmann , Lukas Glandorf , Johannes C. Paetzold , Tamaz Amiranashvili , Thomas Wälchli , Daniel Razansky , Bjoern Menze

Purpose: To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy (DR). Methods: A deep learning convolutional neural network (CNN) architecture VGG16 was employed…

Quantitative Methods · Quantitative Biology 2021-12-16 David Le , Minhaj Alam , Cham Yao , Jennifer I. Lim , R. V. P. Chan , Devrim Toslak , Xincheng Yao

Optical coherence tomography angiography (OCTA) shows its great importance in imaging microvascular networks by providing accurate 3D imaging of blood vessels, but it relies upon specialized sensors and expensive devices. For this reason,…

Computer Vision and Pattern Recognition · Computer Science 2025-04-03 Zhuangzhuang Chen , Hualiang Wang , Chubin Ou , Xiaomeng Li
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