Related papers: From jamming to collective cell migration through …

Many critical biological processes, like wound healing, require confluent cell monolayers/bulk tissues to transition from a jammed solid-like to a fluid-like state. Although numerical studies anticipate changes in the cell shape alone can…

Collective cell motility plays central roles in various biological phenomena such as inflammatory response, wound healing, cancer metastasis and embryogenesis. These are biological demonstrations of the unjamming transition. However,…

Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion.…

The transition of an epithelial layer from a stationary, quiescent state to a highly migratory, dynamic state is required for wound healing, development, and regeneration. This transition, known as the unjamming transition (UJT), is…

Growth in confined spaces can drive cellular populations through a jamming transition from a fluid-like state to a solid-like state. Experiments have found that jammed budding yeast populations can build up extreme compressive pressures…

Transitions between solid-like and fluid-like states in living tissues have been found in steps of embryonic development and in stages of disease progression. Our current understanding of these transitions has been guided by experimental…

Collective cell migration is essential for a wide range of biological processes such as: morphogenesis, wound healing, and cancer spreading. However, it is well known that migrating epithelial collectives frequently undergo jamming, stay…

The cellular automaton model for traffic flow exhibits a jamming transition from a free-flow phase to a congested phase. In the deterministic case this transition corresponds to a critical point with diverging correlation length. We present…

In living and engineered systems of active particles, self-propulsion induces an unjamming transition from a solid to a fluid phase and phase separation between a gas and a liquid-like phase. We demonstrate an interplay between these two…

The rheology of biological tissue plays an important role in many processes, from organ formation to cancer invasion. Here, we use a multi-phase field model of motile cells to simulate active microrheology within a tissue monolayer. When…

The cellular automaton model for traffic flow exhibits a jamming transition from a free-flow phase to a congested phase. In the deterministic case this transition corresponds to a critical point with diverging correlation length. In the…

Collective cell motility is crucial to many biological processes including morphogenesis, wound healing, and cancer invasion. Recently, the biology and biophysics communities have begun to use the term cell jamming to describe the…

The phase structure of self-avoiding polymerized membranes is studied by extensive Hybrid Monte Carlo simulations. Several folding transitions from the flat to a collapsed state are found. Using a suitable order parameter and finite size…

We consider a model for driven particulate matter in which absorbing states can be reached both by particle isolation and by particle caging. The model predicts a non-equilibrium phase diagram in which analogues of hydrodynamic and elastic…

Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-liquid and glass-liquid transitions. These transitions are biologically relevant to our understanding of embryonic development, wound healing, and…

Jamming is a ubiquitous phenomenon that appears in many soft matter systems, including granular materials, foams, colloidal suspensions, emulsions, polymers, and cells -- when jamming occurs, the system undergoes a transition from flow-like…

We use a computational phase-field model together with analytical analysis to study how inter-cellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. Contractile inter-cellular…

We study numerically the phases and dynamics of a dense collection of self-propelled particles with soft repulsive interactions in two dimensions. The model is motivated by recent in vitro experiments on confluent monolayers of migratory…

The investigation of collective behaviour in dense assemblies of self-propelled active particles has been motivated by a wide range of biological phenomena. Of particular interest are dynamical transitions of cellular and sub-cellular…

Angiogenesis is the complex process by which new blood vessels develop from an existing vasculature in order to supply nutrients and/or metabolites to tissues, playing a fundamental role in many physiological and pathological conditions…