Related papers: From jamming to collective cell migration through …
The origin of nonlinear responses in cells has been suggested to be crucial for various cell functions including the propagation of the nervous impulse. In physics nonlinear behavior often originates from phase transitions. Evidence for…
Quantifying the outcomes of cells collisions is a crucial step in building the foundations of a kinetic theory of living matter. Here, we develop a mechanical theory of such collisions by first representing individual cells as extended…
Tuning cell rearrangements is essential in collective cell movement that underlies cancer progression, wound repair, and embryonic development. A key question is how tissue material properties and morphology emerge from cellular factors…
We investigate the jamming transition in packings of emulsions and granular materials via molecular dynamics simulations. The emulsion model is composed of frictionless droplets interacting via nonlinear normal forces obtained using…
The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We…
By minimizing the enthalpy of packings of frictionless particles, we obtain jammed solids at desired pressures and hence investigate the jamming transition with and without shear. Typical scaling relations of the jamming transition are…
Jamming describes a transition from a flowing or liquid state to a solid or rigid state in a loose assembly of particles such as grains or bubbles. In contrast, clogging describes the ceasing of the flow of particulate matter through a…
A wide variety of interacting particle assemblies driven by an external force are characterized by a transition between a blocked and a moving phase. The origin of this deblocking transition can be traced back to the presence of either…
Amorphous materials as diverse as foams, emulsions, colloidal suspensions and granular media can {\em jam} into a rigid, disordered state where they withstand finite shear stresses before yielding. The jamming transition has been studied…
The non-equilibrium transition from a fluid-like state to a disordered solid-like state, known as the jamming transition, occurs in a wide variety of physical systems, such as colloidal suspensions and molecular fluids, when the temperature…
We study the steady-state response to applied stress in a simple scalar model of sheared colloids. Our model is based on a schematic (F2) model of the glass transition, with a memory term that depends on both stress and shear rate. For…
Many systems in nature exhibit transitions between fluid-like states and solid-like states, or "jamming transitions". There is a strong theoretical foundation for understanding equilibrium phase transitions that involve solidification, or…
During development and under normal physiological conditions, biological tissues are continuously subjected to substantial mechanical stresses. In response to large deformations cells in a tissue must undergo multicellular rearrangements in…
Using three-dimensional representation of confluent cell layers, we map the amorphous solid to fluid phase transition in active cell layers onto the two-dimensional (2D) site percolation universality class. Importantly, we unify two…
Confluent cell monolayers and epithelia tissues show remarkable patterns and correlations in structural arrangements and actively-driven collective flows. We simulate these properties using multiphase field models. The models are based on…
Athermal packings of soft repulsive spheres exhibit a sharp jamming transition in the thermodynamic limit. Upon further compression, various structural and mechanical properties display clean power-law behavior over many decades in…
We study the flow behavior and unjamming transition in dense assemblies of actively deforming particles that periodically change size, a process that we refer to as breathing. Using extensive molecular dynamics simulations and a…
We study the rheology of amorphous packings of soft, frictionless particles close to jamming. Implementing a quasistatic simulation method we generate a well defined ensemble of states that directly samples the system at its yield-stress. A…
Colloidal and other granular media experience a transition to rigidity known as jamming if the fill fraction is increased beyond a critical value. The resulting jammed structures are locally disordered, bear applied loads inhomogenously,…
Interstitial fluid flow is a feature of many solid tumours. In vitro Experiments have shown that such fluid flow can direct tumour cell movement upstream or downstream depending on the balance between the competing mechanisms of tensotaxis…