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The health effects of environmental exposures have been studied for decades, typically using standard regression models to assess exposure-outcome associations found in observational non-experimental data. We propose and illustrate a…

Applications · Statistics 2017-09-20 Marie-Abele C. Bind , Donald B. Rubin

Understanding the causal effects of air pollution exposures on social mobility is attracting increasing attention. At the same time, education is widely recognized as a key driver of social mobility. However, the causal pathways linking…

In epidemiological studies of air pollution and public health, estimating the health impact of exposure to air pollution may be hindered by the unknown functional form of the exposure-outcome association and by unmeasured confounding…

Methodology · Statistics 2026-01-28 Carlo Zaccardi , Pasquale Valentini , Luigi Ippoliti , Alexandra M. Schmidt

We propose a new approach for estimating causal effects when the exposure is measured with error and confounding adjustment is performed via a generalized propensity score (GPS). Using validation data, we propose a regression calibration…

We develop new methodology to improve our understanding of the causal effects of multivariate air pollution exposures on public health. Typically, exposure to air pollution for an individual is measured at their home geographic region,…

Methodology · Statistics 2025-11-18 Heejun Shin , Danielle Braun , Kezia Irene , Michelle Audirac , Joseph Antonelli

This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and…

Applications · Statistics 2007-11-01 Gavin Shaddick , Duncan Lee , James V. Zidek , Ruth Salway

Numerous studies have examined the associations between long-term exposure to fine particulate matter (PM2.5) and adverse health outcomes. Recently, many of these studies have begun to employ high-resolution predicted PM2.5 concentrations,…

Methodology · Statistics 2022-11-29 Kevin P. Josey , Priyanka deSouza , Xiao Wu , Danielle Braun , Rachel Nethery

When exposure measurement error (EME), confounder measurement error (CME), or both are present, health effect estimates regarding exposure mixtures and critical exposure time-window may not represent the true effects. For example, in air…

Statistics Theory · Mathematics 2025-05-28 Honghyok Kim

Several epidemiological studies have provided evidence that long-term exposure to fine particulate matter (PM2.5) increases mortality risk. Furthermore, some population characteristics (e.g., age, race, and socioeconomic status) might play…

Methodology · Statistics 2023-11-01 Dafne Zorzetto , Falco J. Bargagli-Stoffi , Antonio Canale , Francesca Dominici

A typical problem in air pollution epidemiology is exposure assessment for individuals for which health data are available. Due to the sparsity of monitoring sites and the limited temporal frequency with which measurements of air pollutants…

The opportunity to assess short term impact of air pollution relies on the causal interpretation of the exposure-outcome association, but up to now few studies explicitly faced this issue within a causal inference framework. In this paper,…

Ambient exposure to fine particulate matters of diameters smaller than 2.5{\mu}m (PM2.5) has been identified as one critical cause for respiratory disease. Disparities in exposure to PM2.5 among income groups at individual residences are…

Physics and Society · Physics 2022-06-01 Chao Fan , Yu-Heng Chien , Ali Mostafavi

Exposure to fine particulate matter ($PM_{2.5}$) poses significant health risks and accurately determining the shape of the relationship between $PM_{2.5}$ and health outcomes has crucial policy ramifications. While various statistical…

Applications · Statistics 2023-06-06 Michael Cork , Daniel Mork , Francesca Dominici

Statistical Learning methodology for analysis of large collections of cross-sectional observational data can be most effective when the approach used is both Nonparametric and Unsupervised. We illustrate use of our NU Learning approach on…

Computers and Society · Computer Science 2023-01-03 Robert L. Obenchain , S. Stanley Young

One way to quantify exposure to air pollution and its constituents in epidemiologic studies is to use an individual's nearest monitor. This strategy results in potential inaccuracy in the actual personal exposure, introducing bias in…

Statistical techniques used in air pollution modelling usually lack the possibility to understand which predictors affect air pollution in which functional form; and are not able to regress on exceedances over certain thresholds imposed by…

Methodology · Statistics 2021-05-25 Nadja Klein , Jorge Mateu

Analysis of observational studies increasingly confronts the challenge of determining which of a possibly high-dimensional set of available covariates are required to satisfy the assumption of ignorable treatment assignment for estimation…

Methodology · Statistics 2022-03-23 Chanmin Kim , Mauricio Tec , Corwin M Zigler

Statistical models often require inputs that are not completely known. This can occur when inputs are measured with error, indirectly, or when they are predicted using another model. In environmental epidemiology, air pollution exposure is…

Methodology · Statistics 2025-12-23 Konstantin Larin , Daniel R. Kowal

The impact of wildfire smoke on air quality is a growing concern, contributing to air pollution through a complex mixture of chemical species with important implications for public health. While previous studies have primarily focused on…

Methodology · Statistics 2026-02-10 Dafne Zorzetto , Jenna Landy , Corwin Zigler , Giovanni Parmigiani , Roberta De Vito

Environmental epidemiologists are often interested in estimating the effect of time-varying functions of the exposure history on health outcomes. However, the individual exposure measurements that constitute the history upon which an…

Methodology · Statistics 2025-05-23 Ce Yang , Ning Zhang , Jiaxuan Li , Unnati V. Mehta , Jaime E. Hart , Donna Spiegelman , Molin Wang
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